Macrosomia, cardiac hypertrophy, erythroblastosis, and hyperplasia of the islands of langerhans in infants born to diabetic mothers

Miller, Herbert C.; Wilson, Hugh M.

doi:10.1016/s0022-3476(43)80001-9

Cited by 81 publications

(14 citation statements)

References 13 publications

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“…Histological analyses of the hearts of ODR demonstrated decrease of cellular nuclei size confirming reduction of cardiac hypertrophy during the first 21 days of life, a feature also expected to occur in human infant 8 . In gestational diabetes mellitus, the fetus produces insulin for its own metabolism and for its mother's.…”

Section: Discussionsupporting

confidence: 60%

“…According to Pildes, fetal insulin stimulation increases the number of cells, nuclei and myocardial fibers, because fetal myocardial tissue has more insulin receptors than the adult tissue. Moreover, IDMs with high insulin levels have more insulin receptors, greater affinity for insulin and a greater capacity to use insulin 8 .…”

Section: Introductionmentioning

confidence: 99%

“…An increase in the number of cells, nuclei and myocardial fibers is seen in fetal hypertrophic cardiomyopathy. The septum is hypertrophic, and there is loss of left ventricular function and obstruction of its exit flow, which may explain why many IDMs without congenital cardiomyopathy show signs of myocardial insufficiency 8 . This condition may resolve in 8 to 12 weeks 8 .…”

Section: Introductionmentioning

confidence: 99%

“…The septum is hypertrophic, and there is loss of left ventricular function and obstruction of its exit flow, which may explain why many IDMs without congenital cardiomyopathy show signs of myocardial insufficiency 8 . This condition may resolve in 8 to 12 weeks 8 . According to Zielinsky 13 , gestational diabetes has the same potential to cause fetal ventricular cardiomyopathy as previous diabetes.…”

Section: Introductionmentioning

confidence: 99%

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Regression of gestational diabetes induced cardiomegaly in offspring of diabetic rat

et al. 2009

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Purpose:To compare body weight and length, heart weight and length, heart-to-body weight ratio, glycemia, and morphometric cellular data of offspring of diabetic rats (ODR) and of normal rats (control). Methods: Diabetes was induced in 3 pregnant Wistar rats, bearing 30 rats, on the 11th day after conception by intraperitoneal injection of 50 mg/kg of streptozotocin. Six normal pregnant Wistar rats, bearing 50 rats, made up the control group. Morphometric data were obtained using a scale for the weight, length, heart and body measurements. Morphometric cellular data were obtained by a computer assisted method applied to the measurements of myocytes. Statistical analysis utilized Student's t-test, ANOVA and Levene test. Results: Control offspring had greater mean body weight and length than offspring of diabetic rats (p < 0.001). Heart weight and length and heart-to-body ratios of newborn rats differed between groups at birth (p < 0.001), but showed no difference at 21 days. Mean nuclei area and perimetric value of the myocytes decrees throughout the first 21 days of life (p < 0.01) in the diabetic group. Conclusions: Heart hypertrophy on the offspring of diabetic rats at birth was demonstrated by the significant difference between the groups. After the eleventh day, no difference was found, which confirmed regression of cardiomegaly. The significant difference between the first and the 21th day of life, for nuclei area feature, demonstrate regression of cardiac hypertrophy in the offspring of diabetic rats. Key words: Diabetes, Gestational. Cardiomyopathy, Hypertrophic. Rats. RESUMO Objetivo:Comparar as medidas cardíacas e a morfometria celular miocárdica dos filhotes de ratas diabéticas (FRD) com filhotes de ratas normais (FRN). Métodos: Foram estudados 30 filhotes de 3 ratas Wistar com diabetes gestacional induzido por 50mg/kg de estreptozotocina, no 11° dia após a concepção. O grupo controle foi de 50 filhotes de 6 ratas Wistar normais. As medidas de comprimento, peso corporal e peso cardíaco foram realizadas com paquímetro e balança e as medidas celulares por analisador computadorizado de imagem. A análise estatística usou o Teste t de Student, ANOVA e teste de Levene. Resultados: A média de peso e comprimento dos filhotes, desde o nascimento até os 21 dias de vida, foi significativamente maior (p<0,001) no grupo dos FRN. O peso, tamanho cardíaco e a proporção cardíaca dos FRD, ao nascimento, foi, significativamente, maior (p<0,001), regredindo ao longo dos 21 dias de vida. Os FRD apresentaram uma regressão significativa da área e perímetro nuclear (p<0,01) do nascimento aos 21 dias de vida, o mesmo não ocorrendo no grupo controle. Conclusões: Os FRD apresentaram, ao nascimento, maior tamanho cardíaco, maior peso cardíaco e maior proporção peso cardíaco-peso corporal do que FRN, havendo igualdade estatística entre os dois grupos a partir do 11° dia de vida. Houve diferença significativa entre o nascimento e o 21 o dia de vida nas medidas celulares demonstrando regressão da hipertrofia miocárdica nos...

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Section: Discussionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Regression of gestational diabetes induced cardiomegaly in offspring of diabetic rat

et al. 2009

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“…Cardiomegaly [4] and obstructive and nonobstructive cardiomyo pathy [5], all occur more frequently in IDM's. In view of these considerations, we chose to examine the effect of maternal alloxan-in duced diabetes on the ability of the neonatal rabbit pup to sustain hypoxia and the role of the heart in that adaptation.…”

mentioning

confidence: 99%

Effect of Maternal Diabetes on Response to Hypoxia in the Newborn Rabbit

Epstein¹,

Hartig-Beecken²,

Loo³

1981

Neonatology

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We tested the hypothesis that maternal diabetes is associated with a decreased ability of the newborn to tolerate hypoxia by measuring the time to last gasp of rabbit pups born to diabetic and control does and placed in 100% N₂. Rabbits were made diabetic by injection of 100mg/kg alloxan i.v. The alloxan-treated mothers had significantly elevated blood glucose during pregnancy and at delivery (132 vs. 90 mg/dl, p < 0.001). Pups were delivered at 30 days’ gestation by hysterotomy under local anesthesia. Half of each litter were immediately sacrificed and the remaining pups placed in 100% N₂. The pups from the alloxan-treated mothers showed a higher pre-asphyxial mean blood glucose (97 vs. 73 mg/dl, p < 0.025) and a lower mean survival time (18.4 vs. 21.1 min, p < 0.005).

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Pulmonary Hyaline Membranes in Infants of Diabetic Mothers

Winter¹

1954

Arch Pediatr Adolesc Med

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Macrosomia, cardiac hypertrophy, erythroblastosis, and hyperplasia of the islands of langerhans in infants born to diabetic mothers

Cited by 81 publications

References 13 publications

Regression of gestational diabetes induced cardiomegaly in offspring of diabetic rat

Regression of gestational diabetes induced cardiomegaly in offspring of diabetic rat

Effect of Maternal Diabetes on Response to Hypoxia in the Newborn Rabbit

Pulmonary Hyaline Membranes in Infants of Diabetic Mothers

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