Macroscopic sessile tumor architecture is a pathologic feature of biologically aggressive upper tract urothelial carcinoma

Fritsche, Hans Martin; Novara, Giacomo; Burger, Maximilian; Gupta, Amit; Matsumoto, Kazumasa; Kassouf, Wassim; Sircar, Kanishka; Zattoni, Filiberto; Walton, Tom; Tritschler, Stefan; Baba, Shirō; Bastian, Patrick J.; Martínez-Salamanca, Juan Ignacio; Seitz, Christian; Otto, Wolfgang; Wieland, Wolf F.; Karakiewicz, Pierre I.; Ficarra, Vincenzo; Hartmann, Arndt; Shariat, Shahrokh F.

doi:10.1016/j.urolonc.2010.07.010

Cited by 64 publications

(36 citation statements)

References 17 publications

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“…For example, the Yates nomogram is only for use in patients with urothelial carcinoma and not suitable for other subtypes like squamous cell carcinoma. Also, this nomogram do not include risk factors that have shown to correlate significantly with the clinical outcome of patients, including bladder tumour history (Milojevic et al , 2012), preoperative hydronephrosis grade (Ito et al , 2011), tumour multifocality (Chromecki et al , 2012), lymphovascular invasion (Akao et al , 2008; Lin et al , 2008; Godfrey et al , 2012), tumour architecture (Fritsche et al , 2012), and tumour necrosis (Lee et al , 2007; Zigeuner et al , 2010). Cha et al (2012) and Rouprêt et al (2013) developed the prognostic models and confirmed the importance of lymphovascular invasion and tumour architecture, two strong prognostic variables that have been associated with features of biologically and clinically aggressive UUT-UC.…”

Section: Discussionmentioning

confidence: 99%

External validation of an online nomogram in patients undergoing radical nephroureterectomy for upper urinary tract urothelial carcinoma

Moon

Jung

et al. 2013

Br J Cancer

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Background:The objective was to validate an online nomogram developed based on the French collaborative national database on upper urinary tract urothelial carcinoma (UUT-UC) using a different cohort.Methods:The study comprised 328 patients with UUT-UC who underwent radical nephroureterectomy. The discrimination of models was quantified using Harrell's concordance index. The relationship between the model-derived and actuarial cancer-specific mortality was graphically explored within calibration plots. Calibration was also assessed using the quartiles of the predicted survival at 3 and 5 years and calculation of the corresponding observed Kaplan–Meier estimates. Clinical net benefit was evaluated constructing decision curve analysis.Results:The discrimination accuracy of the nomograms at 3 and 5 years was 71.6% and 71.8%, respectively. Although nomograms discriminated well by Kaplan–Meier curves, and log-rank tests were all highly significant, the calibration plots tended to exaggerate the overestimation of mortality between predicted and observed probabilities at 3 and 5 years for survival. When compared with the AJCC/UICC staging system, the nomograms performed well across a wide range of threshold probabilities using decision curve analysis.Conclusion:The online nomogram is a highly accurate prognostic tool for patients with UUT-UC treated with radical nephroureterectomy. The model can provide an accurate estimate of the individual risk of cancer-specific mortality. Further improvement and implementation of novel molecular marker is needed.

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Section: Discussionmentioning

confidence: 99%

External validation of an online nomogram in patients undergoing radical nephroureterectomy for upper urinary tract urothelial carcinoma

Moon

Jung

et al. 2013

Br J Cancer

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“…3). L'urétéro-rénoscopie va permettre une exploration de P. Colin et al l'ensemble de la VES dans 95 %, de renseigner l'urologue sur l'aspect macroscopique et le nombre des lésions (l'aspect sessile et la multifocalité étant des facteurs pronostiques défavorables) [46,53]. Une cytologie urinaire positive pré-dit une TVES de haut grade avec une sensibilité de 56 % et une tumeur infiltrante avec une sensibilité de 62 % [22,54].…”

Section: Surveillance Des Tvesunclassified

Surveillance des carcinomes urothéliaux : revue du Comité de cancérologie de l’Association française d’urologie

Colin

Pignot

Rouprêt

et al. 2015

Progrès en Urologie

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“…Les tumeurs sessiles, telles qu'évaluées en endoscopie et en imagerie, étaient corrélées à des TVES de stade élevé, de haut grade et à un envahissement ganglionnaire [36,37].…”

Section: L'architecture Tumoraleunclassified

Facteurs pronostiques des tumeurs de la voie excrétrice supérieure et impact sur la survie : une revue systématique pour le rapport annuel de l’Association française d’urologie

Colin

Irani

Drouin³

et al. 2014

Progrès en Urologie

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Macroscopic sessile tumor architecture is a pathologic feature of biologically aggressive upper tract urothelial carcinoma

Cited by 64 publications

References 17 publications

External validation of an online nomogram in patients undergoing radical nephroureterectomy for upper urinary tract urothelial carcinoma

External validation of an online nomogram in patients undergoing radical nephroureterectomy for upper urinary tract urothelial carcinoma

Surveillance des carcinomes urothéliaux : revue du Comité de cancérologie de l’Association française d’urologie

Facteurs pronostiques des tumeurs de la voie excrétrice supérieure et impact sur la survie : une revue systématique pour le rapport annuel de l’Association française d’urologie

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