Macroscopic fast neuronal oscillations and synchrony in schizophrenia

Stelt, Odin van der; Belger, Ayşenil; Lieberman, Jeffrey A.

doi:10.1073/pnas.0407688101

Cited by 26 publications

(14 citation statements)

References 25 publications

(23 reference statements)

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“…In agreement with LFP studies (Cassim et al, 2002;Magill et al, 2004;Van der Stelt et al, 2004;Boraud et al, 2005;Lee et al, 2006;Pediaditakis, 2006;Light et al, 2006), the electrophysiological network exhibits an oscillatory dynamical behaviour. Oscillations in neurotransmitter concentrations are expected due to the feedback-loops in the network, the non-linearities of the equations as well as the time delays.…”

Section: Discussionsupporting

confidence: 81%

Neurochemical Oscillations in the Basal Ganglia

Noori

Jäger

2009

Bull. Math. Biol.

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This work represents an attempt to elucidate the neurochemical processes in the basal ganglia by mathematical modelling. The correlation between neurochemistry and electrophysiology has been used to construct a dynamical system based on the basal ganglia's network structure. Mathematical models were constructed for different physical scales to reformulate the neurochemical and electrophysiological behaviour from synapses up to multi-compartment systems. Transformation functions have been developed to transit between the different scales. We show through numerical simulations that this network produces oscillations in the electrical potentials as well as in neurotransmitter concentrations. In agreement with pharmacological experiments, a parameter sensitivity analysis reveals temporary changes in the neurochemical and electrophysiological systems after single exposure to antipsychotic drugs. This behaviour states the structural stability of the system. The correlation between the neurochemical dynamics and drug-induced behaviour provides the perspective for novel neurobiological hypotheses.

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Section: Discussionsupporting

confidence: 81%

Neurochemical Oscillations in the Basal Ganglia

Noori

Jäger

2009

Bull. Math. Biol.

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“…13) Oscillatory synchrony has been implicated in several cognitive functions including feature binding and scene segmentation, 14) memory formation and recall, 15) and attention. 16) Moreover, it has been reported that synchronization processes are associated with neuropsychiatric disorders such as epilepsy, 17) schizophrenia, 18) dementia, 19) and Parkinson's disease. 20) It is well known that epileptic seizures involve excessive discharge and abnormal electrical behavior of neurons.…”

mentioning

confidence: 99%

Neuroprotective Effect of Piperine on Primarily Cultured Hippocampal Neurons

Sun

Zuo

2010

Biological & Pharmaceutical Bulletin

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It was previously reported that piperine (PIP) significantly blocks convulsions induced by intracerebroventricular injection of threshold doses of kainate, but had no or only slight effects on convulsions induced by L-glutamate, N-methyl-D-aspartate and guanidinosuccinate. In traditional Chinese medicine, black pepper has been used for epileptic treatment; however, the exact mechanism is still unclear. We reported here in that appropriate concentration of PIP effectively inhibites the synchronized oscillation of intracellular calcium in rat hippocampal neuronal networks and represses spontaneous synaptic activities in terms of spontaneous synaptic currents (SSC) and spontaneous excitatory postsynaptic currents (sEPSC). Moreover, pretreatment with PIP expects protective effect on glutamate-induced decrease of cell viability and apoptosis of hippocampal neurons. These data suggest that the neuroprotective effects of PIP might be associated with suppression of synchronization of neuronal networks, presynaptic glutamic acid release, and Ca 2؉ overloading.

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“…In parallel, abnormal synchronization patterns in the motor system appears to be a key pathophysiological mechanism behind motor symptoms such as tremors in Parkinson’s disease 7. There is emerging evidence that “a delicately balanced patterns of synchronization and desynchronization is functionally and behaviorally important” for normal brain activity, and that abnormalities in neural synchrony are related to a number of neuropsychiatric disorders including epilepsy,68 schizophrenia82 and Parkinson’s disease 31. Hence, it is logical to consider an interplay of synchronization and desynchronization processes in order to model normal and pathological brain dynamics.…”

Section: Modeling Approachmentioning

confidence: 99%

Homeostasis of Brain Dynamics in Epilepsy: A Feedback Control Systems Perspective of Seizures

et al. 2009

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In an effort to understand basic functional mechanisms that can produce epileptic seizures, some key features are introduced in coupled lumped-parameter neural population models that produce "seizure"-like events and dynamics similar to the ones during the route of the epileptic brain towards seizures. In these models, modified from existing ones in the literature, internal feedback mechanisms are incorporated to maintain the normal low level of synchronous behavior in the presence of coupling variations. While the internal feedback is developed using basic feedback systems principles, it is also functionally equivalent to actual neurophysiological mechanisms such as homeostasis that act to maintain normal activity in neural systems that are subject to extrinsic and intrinsic perturbations. Here it is hypothesized that a plausible cause of seizures is a pathology in the internal feedback action; normal internal feedback quickly regulates an abnormally high coupling between the neural populations, whereas pathological internal feedback can lead to "seizure"-like high amplitude oscillations. Several external seizure-control paradigms, that act to achieve the operational objective of maintaining normal levels of synchronous behavior, are also developed and tested in this paper. In particular, closed-loop "modulating" control with predefined stimuli, and closed-loop feedback decoupling control are considered. Among these, feedback decoupling control is the consistently successful and robust seizure-control strategy. The proposed model and remedies are consistent with a variety of recent observations in the human and animal epileptic brain, and with theories from nonlinear systems, adaptive systems, optimization, and neurophysiology. The results from the analysis of these models have two key implications, namely, developing a basic theory for epilepsy and other brain disorders, and the development of a robust seizure-control device through electrical stimulation and/or drug intervention modalities.

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Macroscopic fast neuronal oscillations and synchrony in schizophrenia

Cited by 26 publications

References 25 publications

Neurochemical Oscillations in the Basal Ganglia

Neurochemical Oscillations in the Basal Ganglia

Neuroprotective Effect of Piperine on Primarily Cultured Hippocampal Neurons

Homeostasis of Brain Dynamics in Epilepsy: A Feedback Control Systems Perspective of Seizures

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