Macroscopic and microscopic investigation of maximum effectiveness of proton-boron capture therapy using Monte Carlo simulation

Ahmadi Ganjeh, Zahra; Mosleh-Shirazi, Mohammad Amin

doi:10.1016/j.radphyschem.2023.111289

Radiation Physics and Chemistry

2024

DOI: 10.1016/j.radphyschem.2023.111289

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Macroscopic and microscopic investigation of maximum effectiveness of proton-boron capture therapy using Monte Carlo simulation

Zahra Ahmadi Ganjeh,

Mohammad Amin Mosleh-Shirazi

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Ionization Detail Parameters for DNA Damage Evaluation in Charged Particle Radiotherapy: Simulation Study Based on Cell Survival Database

Mietelska,

Pietrzak,

Bancer

et al. 2024

IJMS

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Details of excitation and ionization acts hide a description of the biological effects of charged particle traversal through living tissue. Nanodosimetry enables the introduction of novel quantities that characterize and quantify the particle track structure while also serving as a foundation for assessing biological effects based on this quantification. This presents an opportunity to enhance the planning of charged particle radiotherapy by taking into account the ionization detail. This work uses Monte Carlo simulations with Geant4-DNA code for a wide variety of charged particles and their radiation qualities to analyze the distribution of ionization cluster sizes within nanometer-scale volumes, similar to DNA diameter. By correlating these results with biological parameters extracted from the PIDE database for the V79 cell line, a novel parameter R2 based on ionization details is proposed for the evaluation of radiation quality in terms of biological consequences, i.e., radiobiological cross section for inactivation. By incorporating the probability p of sub-lethal damage caused by a single ionization, we address limitations associated with the usually proposed nanodosimetric parameter Fk for characterizing the biological effects of radiation. We show that the new parameter R2 correlates well with radiobiological data and can be used to predict biological outcomes.

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Ionization Detail Parameters for DNA Damage Evaluation in Charged Particle Radiotherapy: Simulation Study Based on Cell Survival Database

Mietelska,

Pietrzak,

Bancer

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

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Macroscopic and microscopic investigation of maximum effectiveness of proton-boron capture therapy using Monte Carlo simulation

Cited by 1 publication

References 32 publications

Ionization Detail Parameters for DNA Damage Evaluation in Charged Particle Radiotherapy: Simulation Study Based on Cell Survival Database

Ionization Detail Parameters for DNA Damage Evaluation in Charged Particle Radiotherapy: Simulation Study Based on Cell Survival Database

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