Macroscopic amoxicillin crystalluria

Hentzien, Maxime; Lambert, D.; Limelette, Anne; N’Guyen, Yohan; Robbins, A.; Lebrun, Delphine; Jaussaud, R.; Bani-Sadr, F.

doi:10.1016/s0140-6736(14)62001-8

Cited by 22 publications

(31 citation statements)

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“…Based on previous case reports, AICN diagnosis was retained if cases fulfilled all of the criteria of AICN diagnosis and none of the exclusion criteria (Table 1) (2,4,6). AKI was staged according to the Kidney Disease Improving Global Outcomes criteria (KDIGO) (36).…”

Section: Methodsmentioning

confidence: 99%

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Dramatic Increase of Amoxicillin-Induced Crystal Nephropathy Found in a Cohort Study of French Pharmacovigilance Centers

Vodovar

Thomas

Lepeule

et al. 2018

Antimicrob Agents Chemother

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An increase in amoxicillin-induced crystal nephropathy (AICN) incidence has been recently suggested. The aims of this study were to investigate the trend of AICN incidence through Paris' regional centers of pharmacovigilance (Paris RCPVs) and better describe this rare adverse drug reaction. Forty-five AICN cases were identified between 1985 and 2016. All cases, except one, were reported since 2010. Amoxicillin (AMX) was administered intravenously (65 [interquartile range {IQR}, 43 to 110] mg/kg of body weight/day) in all patients, either for treating infection ( = 15) or as surgical prophylaxis ( = 30). Delay between AMX administration and AICN onset was 1 (IQR, 1 to 3) day; 30, 4, and 11 patients developed KDIGO stage 1, 2, and 3 acute kidney injury, respectively. Delay between AICN onset and kidney function recovery was 4 (IQR, 2 to 6) days. Precipitating factors were identified in only one-third of cases. Twelve patients required intensive care unit admission, and 8 needed renal replacement therapy. Neither chronic kidney disease nor death was observed. We confirmed the recent and dramatic increase of AICN in the Paris RCPVs since 2010. The absence of precipitating factors in the majority of cases and the onset of AICN in apparent routine indications, such as surgical prophylaxis, are alarming and justify a high vigilance from all AMX prescribers.

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Section: Methodsmentioning

confidence: 99%

“…However, AICN associated with preserved urinary output and/or microscopic hematuria as isolated AMX crystalluria without AKI have also been described (2). Although outcome is usually favorable after AMX discontinuation, renal replacement therapy may be temporarily required (4).…”

mentioning

confidence: 99%

Dramatic Increase of Amoxicillin-Induced Crystal Nephropathy Found in a Cohort Study of French Pharmacovigilance Centers

Vodovar

Thomas

Lepeule

et al. 2018

Antimicrob Agents Chemother

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“…s described by Hentzien et al recently, amoxicillin is a drug that can crystallize in the urinary tract as amoxicillin trihydrate and lead to macroscopic hematuria and acute renal insufficiency through tubular obstruction (1). However, amoxicillin crystalluria is a rare event (2-4) whose incidence remains unknown.…”

mentioning

confidence: 99%

Amoxicillin Crystalluria, an Emerging Complication with an Old and Well-Known Antibiotic

Zeller

Puyraimond-Zemmour

Sené

et al. 2016

Antimicrob Agents Chemother

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“…A s described by Hentzien et al recently, amoxicillin is a drug that can crystallize in the urinary tract as amoxicillin trihydrate and lead to macroscopic hematuria and acute renal insufficiency through tubular obstruction (1). However, amoxicillin crystalluria is a rare event (2-4) whose incidence remains unknown.…”

mentioning

confidence: 99%

Amoxicillin crystalluria: an emerging complication with an old and well-known antibiotic

Zeller¹

2016

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Macroscopic amoxicillin crystalluria

Cited by 22 publications

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Dramatic Increase of Amoxicillin-Induced Crystal Nephropathy Found in a Cohort Study of French Pharmacovigilance Centers

Dramatic Increase of Amoxicillin-Induced Crystal Nephropathy Found in a Cohort Study of French Pharmacovigilance Centers

Amoxicillin Crystalluria, an Emerging Complication with an Old and Well-Known Antibiotic

Amoxicillin crystalluria: an emerging complication with an old and well-known antibiotic

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