Macroporous composite IPN hydrogels based on poly(acrylamide) and chitosan with tuned swelling and sorption of cationic dyes

Drăgan, Ecaterina Stela; Lazăr, Maria; Dinu, Maria Valentina; Doroftei, Florica

doi:10.1016/j.cej.2012.07.126

Cited by 118 publications

(57 citation statements)

References 62 publications

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“…However, CLMS and SEM images of cryogels were not treated to obtain quantitative structural information. Macroporous semi-interpenetrating polymer networks composite hydrogels were synthesised by cross-linking polymerisation of acrylamide with N,N"-methylenebisacrylamide in the presence of potato starch or an anionic polyelectrolyte at 18 o C. To give quantitative characteristics of cryogels, the sizes of macropores were shown directly on SEM images [249,250]. As a whole, this is useless presentation of the textural characteristics of the cryogels.…”

Section: Diffusion Of Small Molecules Polymers Proteins and Cells Wmentioning

confidence: 99%

Cryogels: Morphological, structural and adsorption characterisation

Gun'ko

Savina

Mikhalovsky

2013

Advances in Colloid and Interface Science

281

205

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*Graphical Abstract (for review)Cryotripic gelation technique allows the synthesis of solid and soft macroporous gels Textural characterisation of cryogel in native superhydrated state with noninvasive methods Adsorption and diffusion characteristics of macroporous cryogels with respect to macromolecules and cells Theoretical modelling of adsorption from aqueous media *Highlights (for review) Please find the revised manuscript entitled "Cryogels: morphological, structural and adsorption characterisation" by Vladimir M. Gun'ko, Irina N. Savina, Sergey V. Mikhalovsky to re-consider for publication in the "Advances in Colloid and Interface Science"The paper was completely edited and changed according to reviewers comments.Sincerely yours, Prof. V. M. Gun'koCover Letter ABSTRACTExperimental results on polymer, protein, and composite cryogels and data treatment methods used for morphological, textural, structural, adsorption and diffusion characterisation of the materials are analysed and compared. Treatment of microscopic images with specific software gives quantitative structural information on both native cryogels and freeze-dried materials that is useful to analyse the drying effects on their structure. A combination of cryoporometry, relaxometry, thermoporometry, small angle X-ray scattering (SAXS), equilibrium and kinetic adsorption of low and high-molecular weight compounds, diffusion breakthrough of macromolecules within macroporous cryogel membranes, studying interactions of cells with cryogels provides a consistent and comprehensive picture of textural, structural and adsorption properties of a variety of cryogels. This analysis allows us to establish certain regularities in the cryogel properties related to narrow (diameter 0.4 < d < 2 nm), middle (2 < d < 50 nm) and broad (50 < d < 100 nm) nanopores, micropores (100 nm < d < 100 m) and macropores (d > 100 m) with boundary sizes within modified life science pore classification. Particular attention is paid to water bound in cryogels in native superhydrated or freeze-dried states. At least, five states of water -free unbound, weakly bound (changes in the Gibbs free energy G < 0.5-0.8 kJ/mol) and strongly bound (G > 0.8 kJ/mol), and weakly associated (chemical shift of the proton resonance  H = 1-2 ppm) and strongly associated ( H = 3-6 ppm) waters can be distinguished in hydrated cryogels using 1 H NMR, DSC, TSDC, TG and other methods. Different software for image treatment or developed to analyse the data obtained with the adsorption, diffusion, SAXS, cryoporometry and thermoporometry methods and based on regularisation algorithms is analysed and used for the quantitative morphological, structural and adsorption characterisation of individual and composite cryogels, including polymers filled with solid nano-or microparticles.

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Section: Diffusion Of Small Molecules Polymers Proteins and Cells Wmentioning

confidence: 99%

Cryogels: Morphological, structural and adsorption characterisation

Gun'ko

Savina

Mikhalovsky

2013

Advances in Colloid and Interface Science

281

205

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“…The band at 1553 cm -1 is assigned to amide II in the AM or due to asymmetric vibrations of -COO -existing in the AA, which was also not observed in the original cellulose (Dragan et al 2012). The band at 1320 cm -1 is attributed to amide III (C-N) in the AM (Dragan et al 2012). These characteristic absorptions were detected both in the spectra of the hydrogel products No.…”

Section: Characterization Of Hydrogel Productmentioning

confidence: 76%

“…The characteristic adsorption band at 1662 cm -1 appeared on account of the amide I band stretching vibrations and the overlap of C=O in the AA (Wu et al 2012). The band at 1553 cm -1 is assigned to amide II in the AM or due to asymmetric vibrations of -COO -existing in the AA, which was also not observed in the original cellulose (Dragan et al 2012). The band at 1320 cm -1 is attributed to amide III (C-N) in the AM (Dragan et al 2012).…”

Section: Characterization Of Hydrogel Productmentioning

confidence: 97%

Temperature/pH Sensitive Cellulose-based Hydrogel: Synthesis, Characterization, Loading, and Release of Model Drugs for Potential Oral Drug Delivery

Zhou¹,

Zhu²,

Yang³

et al. 2014

BioResources

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Due to their unique physical and chemical properties, hygrogels have been applied in various industrial and agricultural fields. Biomedicine is another high value-added and attractive area for the application of hydrogels. For this reason, a novel temperature/pH sensitive cellulose based hydrogel was synthesized based on the cellulose from Phyllostachys heterocycla. Its synthesis conditions were optimized, and its loading and release capabilities for model drugs were investigated in detail. The resultant data showed that the synthesized hydrogel exhibited the highest swelling ratio at 37 °C and pH 7.4, corresponding to the temperature and pH of the human intestinal environment. The hydrogel held excellent load performance for model drug MB and an obvious temperature dependence at 37 °C (body temperature of human) when the model drug was released from it. These positive results suggest that the synthesized temperature/pH sensitive cellulose-based hydrogel has a great potential for oral drug delivery applications.

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“…When a linear polymer, either synthetic or biopolymer, is entrapped in a matrix, forming thus a semi-IPN hydrogel, fully-IPN can be prepared after that by a selective crosslinking of the linear polymer chains [97,98].…”

Section: Interpenetrating Polymer Network (Ipn)mentioning

confidence: 99%

History and Applications of Hydrogels

Yahia¹

2015

J Biomed Sci

160

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Hydrogels have existed for more than half century, providing one of the earliest records of crosslinked hydroxyethyl methacrylate (HEMA) hydrogels. Today, hydrogels still fascinate material scientists and biomedical researchers and great strides have been made in terms of their formulations and applications. As a class of material, hydrogels are unique, they consist of a self-supporting, waterswollen three-dimensional (3D) viscoelastic network which permits the diffusion and attachment of molecules and cells. However, hydrogels have recently drawn great attention for use in a wide variety of biomedical applications such as cell therapeutics, wound healing, cartilage/bone regeneration and the sustained release of drugs. This is due to their biocompatibility and the similarity of their physical properties to natural tissue. This review aims to give an overview of the historic and the recent design concept of hydrogels and their several applications based on the old and the most recent publications in this field. Journal of Biomedical Sciences ISSN 2254-609XThis Article is Available in: www.jbiomeds.com 2 Hydrogels can be classified into two distinct categories, the natural and the synthetic hydrogels. Natural hydrogels include collagen, fibrin, hyaluronic acid, matrigel, and derivatives of natural materials such as chitosan, alginate and skill fibers. They remain the most physiological hydrogels as they are components of the extracellular matrix (ECM) in vivo. Two main drawbacks of natural hydrogels, however, make their final microstructures and properties difficult to control reproducibly between experiments. First, the fine details of their mechanical properties and their dependence on polymerization or gelation conditions are often poorly understood. Second, due to their natural origin (bovine fibrinogen, rat tail collagen… their composition may vary from one batch to another.In contrast, synthetic hydrogels such as poly (ethylene glycol) diacrylate, poly(acryl amide), poly(vinyl alcohol) are more reproducible, although their final structure can also depend on polymerization conditions in a subtle way, so that a rigorous control of the preparation protocol, including temperature and environment control, may be necessary. Generally speaking, synthetic hydrogels offer more flexibility for tuning chemical composition and mechanical properties; users can, for example vary the concentration or molecular weight of the precursor, or alter the percentage of crosslinkers. They can also be selected or tuned to be hydrolysable or biodegradable over variable periods of time.Hydrogels may be chemically stable or they may degrade and eventually disintegrate and dissolve. They are called «reversible» or «physical» gels when the networks are held together by molecular entanglements, and/or secondary forces including ionic, H-bonding or hydrophobic forces (Figure 2) [3]. Physical hydrogels are not homogeneous, since clusters of molecular entanglements, or hydrophobically-or ionically-associated domains, can create in h...

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Macroporous composite IPN hydrogels based on poly(acrylamide) and chitosan with tuned swelling and sorption of cationic dyes

Cited by 118 publications

References 62 publications

Cryogels: Morphological, structural and adsorption characterisation

Cryogels: Morphological, structural and adsorption characterisation

Temperature/pH Sensitive Cellulose-based Hydrogel: Synthesis, Characterization, Loading, and Release of Model Drugs for Potential Oral Drug Delivery

History and Applications of Hydrogels

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