Macrophages undergo functionally significant reprograming of nucleotide metabolism upon classical activation
Steven V. John,
Gretchen L. Seim,
Billy J. Erazo-Flores
et al.
Abstract:During an immune response, macrophages systematically rewire their metabolism in specific ways to support their diversve functions. However, current knowledge of macrophage metabolism is largely concentrated on central carbon metabolism. Using multi-omics analysis, we identified nucleotide metabolism as one of the most significantly rewired pathways upon classical activation. Further isotopic tracing studies revealed several major changes underlying the substantial metabolomic alterations: 1)de novosynthesis o… Show more
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