2018
DOI: 10.1016/j.molmed.2018.03.006
|View full text |Cite
|
Sign up to set email alerts
|

Macrophages: The Road Less Traveled, Changing Anticancer Therapy

Abstract: Macrophages are present in all vertebrate tissues and have emerged as multifarious cells with complex roles in development, tissue homeostasis, and disease. Macrophages are a major constituent of the tumor microenvironment, where they either promote or inhibit tumorigenesis and metastasis depending on their state. Successful preclinical strategies to target macrophages for anticancer therapy are now being evaluated in the clinic and provide proof of concept that targeting macrophages may enhance current therap… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

4
259
0

Year Published

2018
2018
2024
2024

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 243 publications
(263 citation statements)
references
References 164 publications
(176 reference statements)
4
259
0
Order By: Relevance
“…Functional plasticity is commonly observed in mononuclear leukocytes. Based on their activation status, macrophages, for example, are categorized into the classically activated, proinflammatory M1 type and the alternatively activated, anti‐inflammatory or immunosuppressive M2 type . In the context of tumors, TAMs potentially undergo a transition from an antitumoral (M1) to a protumoral (M2) activation mode that is instructed by the cytokine milieu in the TME .…”
Section: Neutrophil Subsets In Cancermentioning
confidence: 99%
See 4 more Smart Citations
“…Functional plasticity is commonly observed in mononuclear leukocytes. Based on their activation status, macrophages, for example, are categorized into the classically activated, proinflammatory M1 type and the alternatively activated, anti‐inflammatory or immunosuppressive M2 type . In the context of tumors, TAMs potentially undergo a transition from an antitumoral (M1) to a protumoral (M2) activation mode that is instructed by the cytokine milieu in the TME .…”
Section: Neutrophil Subsets In Cancermentioning
confidence: 99%
“…TAMs are represented by tumor‐resident macrophages (TRMs) and the ones derived from circulating classical monocytes (CCR2 high ) after extravasation into tissues. Both are TME integral cell types that are well characterized and recognized for their contribution to the establishment and spread of cancer . Although bone marrow is the major source of circulating monocytes, spleen can serve as an extramedullary reservoir of monocytic progenitors and supply monocytes into tumors as detected in tumor‐bearing mice .…”
Section: Tams In Cross‐regulating Tans Recruitmentmentioning
confidence: 99%
See 3 more Smart Citations