Macrophages: Past, Present and Future

Herwald, Heiko; Egesten, Arne

doi:10.1159/000356293

Cited by 8 publications

(5 citation statements)

References 21 publications

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“…Macrophages are a diverse and important component of the innate immune system, with versatile functions in host defence and immunity. They are the frontline of defence against foreign microorganisms, including bacteria, parasites, and viruses 1 – 3 . During infection, the inflammatory response of macrophages comprises four stages: recognition of infection by pattern-recognition receptors (PRRs), recruitment of macrophages to infected tissue, elimination of pathogens, and restoration of tissue homeostasis.…”

Section: Introductionmentioning

confidence: 99%

Hypoxia-inducible factor 1α is Essential for Macrophage-mediated Erythroblast Proliferation in Acute Friend Retrovirus Infection

Schreiber

Quinting

Dittmer

et al. 2017

Sci Rep

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Macrophages are the frontline of defence against foreign microorganisms, including bacteria, parasites, and viruses. During acute viral infection, macrophages must invade the inflamed tissue toward low oxygen concentrations, where genetic cellular responses depend on hypoxia-inducible factors (HIF). In the study reported here we investigated the role of HIF-1α in macrophage function during acute retroviral infection. Wild-type and myeloid cell–specific HIF-1α knockout mice were infected with Friend retrovirus (FV), and immune response was analysed 7 and 10 days after infection. FV infection led to increased spleen weight in wild-type and knockout mice, whereas a profound proliferation of erythroblasts was seen only in wild-type mice. The number of spleen-infiltrating macrophages was also significantly lower in knockout animals. Macrophage invasion after FV infection in wild-type mice led to elevated amounts of activated macrophage-stimulating 1 protein that resulted in massive proliferation of erythrocyte precursor cells. This proliferation was absent from knockout mice because of impaired invasion capabilities of HIF-1α–deficient macrophages. Our study elucidated a novel mechanism of FV-induced erythrocyte precursor cell proliferation.

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Section: Introductionmentioning

confidence: 99%

Hypoxia-inducible factor 1α is Essential for Macrophage-mediated Erythroblast Proliferation in Acute Friend Retrovirus Infection

Schreiber

Quinting

Dittmer

et al. 2017

Sci Rep

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show abstract

“…Non-TLR, including the family of scavenger receptors [166] and the C-type lectins [167], are involved in phagocytosis and endocytosis. Opsonic receptors include complement receptors (integrins, such as CD11b) and Fc receptors (immunoglobulin superfamily, such as CD44), which dominate the phagocytosis and endocytosis of complement-or antibody-opsonised particles, respectively [168]. Those phagocytosis-related receptors are, thus, ideal structures for a macrophage-targeting therapy, which can facilitate nano-carriers to deliver therapeutic agents into macrophages selectively.…”

Section: Phagocytosis-related Cell Membrane Receptors Targetingmentioning

confidence: 99%

Current Development of Nano-Drug Delivery to Target Macrophages

Cai

Gao

et al. 2022

Biomedicines

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Macrophages are the most important innate immune cells that participate in various inflammation-related diseases. Therefore, macrophage-related pathological processes are essential targets in the diagnosis and treatment of diseases. Since nanoparticles (NPs) can be preferentially taken up by macrophages, NPs have attracted most attention for specific macrophage-targeting. In this review, the interactions between NPs and the immune system are introduced to help understand the pharmacokinetics and biodistribution of NPs in immune cells. The current design and strategy of NPs modification for specific macrophage-targeting are investigated and summarized.

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“…Recently, increasing attention has been paid to tumor immunosurveillance in the prevention and treatment of tumors 7 , 8 . In particular, macrophages, the most infiltrating immune cells in tumor tissues, can recognize and phagocytose tumor cells through non-specific immunity 9 , followed by T cell-mediated specific immunity, which involves the degradation of tumor cells and the expression of major histocompatibility complex classes I and II on the cell surface 10 , 11 . It is worth to note that a large number of macrophages are required to phagocyte apoptotic tumor cells timely during radiotherapy or chemotherapy, which is critical in promoting the therapeutic effect 12 .…”

Section: Introductionmentioning

confidence: 99%

The disbalance of LRP1 and SIRPα by psychological stress dampens the clearance of tumor cells by macrophages

Luo

Zhou

et al. 2022

Acta Pharmaceutica Sinica B

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The relationship between chronic psychological stress and tumorigenesis has been well defined in epidemiological studies; however, the underlying mechanism remains underexplored. In this study, we discovered that impaired macrophage phagocytosis contributed to the psychological stress-evoked tumor susceptibility, and the stress hormone glucocorticoid (GC) was identified as a principal detrimental factor. Mechanistically, GC disturbed the balance of the “eat me” signal receptor (low-density lipoprotein receptor-related protein-1, LRP1) and the “don't eat me” signal receptor (signal regulatory protein alpha, SIRP α ). Further analysis revealed that GC led to a direct, glucocorticoid receptor (GR)-dependent trans-repression of LRP1 expression, and the repressed LRP1, in turn, resulted in the elevated gene level of SIRP α by down-regulating miRNA-4695-3p. These data collectively demonstrate that stress induces the imbalance of the LRP1/SIRP α axis and entails the disturbance of tumor cell clearance by macrophages. Our findings provide the mechanistic insight into psychological stress-evoked tumor susceptibility and indicate that the balance of LRP1/SIRP α axis may serve as a potential therapeutic strategy for tumor treatment.

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Macrophages: Past, Present and Future

Cited by 8 publications

References 21 publications

Hypoxia-inducible factor 1α is Essential for Macrophage-mediated Erythroblast Proliferation in Acute Friend Retrovirus Infection

Hypoxia-inducible factor 1α is Essential for Macrophage-mediated Erythroblast Proliferation in Acute Friend Retrovirus Infection

Current Development of Nano-Drug Delivery to Target Macrophages

The disbalance of LRP1 and SIRPα by psychological stress dampens the clearance of tumor cells by macrophages

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