Macrophages of the “Heart-Kidney” Axis: Their Dynamics and Correlations with Clinical Data and Outcomes in Patients with Myocardial Infarction

Kercheva, M. A.; Ryabov, V. V.; Gombozhapova, A; Ребенкова, М. С.; Kzhyshkowska, Julia

doi:10.3390/jpm12020127

Cited by 7 publications

(14 citation statements)

References 40 publications

(68 reference statements)

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“…The number of these cells in MI patients was twice as low as that in patients with tubulointerstitial necrosis [25], which may indicate active involvement of this cell type in cardiorenal relationships under ischemic conditions. According to our previous data, the number of CD206+ cells in MI patients with CKD+ and CKD-was different, and the results of the multivariate analysis confirm our assumption about the relevance of studying this cell type as one of the key components of cardiorenal relationships under ischemic conditions [9]. The subsequent detailed analysis of the most pronounced pathological mf, and comparison of the data obtained on the autopsy material with those obtained for patients who have successfully come through MI, will help identify a specific target.…”

Section: Discussionsupporting

confidence: 79%

“…A pronounced heterogeneity of the mf composition in the kidneys with the predominance of CD163+ cells was revealed in this cohort of patients. Among all studied cells we revealed two types-CD206+ and CD80+, which showed significant quantitative dynamics in the late period after MI and a number of relationships with both adverse prognosis and cardiac macrophages [9]. Yet, it remains unclear whether our data indicate changes in the mf composition of the kidneys in response to myocardial ischemia, and whether these changes can affect the course and prognosis of the disease.…”

Section: Introductionmentioning

confidence: 73%

“…We have already reported clinical and anamnestic data on these groups of patients [9]. It should be noted that the average age of the examined patients was 74.8 ± 9.8.…”

Section: Clinical and Anamnestic Characteristicsmentioning

confidence: 92%

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Macrophages of the Cardiorenal Axis and Myocardial Infarction

et al. 2023

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The aim of our study was to compare the features of macrophage (mf) composition of the kidneys in patients with fatal myocardial infarction (MI) and in patients without cardiovascular diseases (CVD). We used kidney fragments taken during autopsy. Macrophage infiltration was assessed by immunohistochemistry: antibodies CD68 were used as a common mf marker, CD80—M1 type mf marker, CD163, CD206, and stabilin-1—M2 type. Macrophage composition of the kidneys in patients with fatal MI was characterized by the predominance of CD163+ cells among studied cells, and the control group was characterized by the predominance of CD163+, CD206+, and CD68+. In patients with MI, biphasic response from kidney cells was characterized for CD80+ and CD206+: their number decreased by the long-term period of MI; other cells did not show any dynamics. The exact number of CD80+ cells in kidneys of individuals without CVD was slightly higher than in patients with MI, and the number of CD206+—strikingly predominant. Subsequent analysis of CD80+ and CD206+ cells in a larger sample, as well as comparison of data with results obtained from survivors of MI, may bring us closer to understanding whether the influence on these cells can serve as a new target in personalized therapy in postinfarction complications.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 73%

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Macrophages of the Cardiorenal Axis and Myocardial Infarction

et al. 2023

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“…These materials also were taken during autopsy and used for histological examination. The criteria for exclusion were MI types II–V, infectious complications (sepsis, pneumonia), oncological diseases, and severe valve diseases [ 13 ]. The Biomedical Ethics Committee of Cardiology Research Institute, of Tomsk National Research Medical Center (protocol No.…”

Section: Methodsmentioning

confidence: 99%

“…The first group included patients who died within the first 3 days after the onset of MI, while the second group included patients with fatal outcome within 4 to 28 days after MI. We have already presented clinical and anamnestic data on these groups of patients [ 13 ]. It should be noted that the age of the examined patients was 74.8 ± 9.8 years.…”

Section: Methodsmentioning

confidence: 99%

Characteristics of the Cardiosplenic Axis in Patients with Fatal Myocardial Infarction

Kercheva

Ryabov

Trusov

et al. 2022

Life

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Myocardial ischemia triggers neurohumoral activation of the cardiosplenic axis. In rodents, adverse outcomes occur upon prolonged entrance of mononuclear cells from the spleen into myocardial tissue. The purpose of this study is to assess the features of spleen structure in patients with fatal myocardial infarction (MI), the dynamics of macrophage infiltration of the spleen and its relationship with cardiac macrophage infiltration and unfavorable outcomes. Using immunohistochemistry techniques, we analyzed the macrophage infiltration of the spleen and myocardium sections collected from patients (n = 30) with fatal MI. The spleen of the patients was decreased and showed a predominance of red pulp with a high concentration of CD68+ and stabilin-1+ cells. The white pulp contained many medium and small follicles and a lower concentration of CD68+ and stabilin-1+ cells, which was comparable to that in the infarct area of the myocardium. The concentration of CD68+ and stabilin-1+ cells increased in the myocardium in the late period of MI, but did not show any dynamics in the spleen. A high number of CD68+ cells in the red pulp and reduced concentration of stabilin-1+ cells in the white pulp were associated with unfavorable post-infarction outcomes. These fundamental findings could be a basis for the development of new personalized therapeutic and diagnostic approaches for the treatment of MI and its complications.

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Place of the cardiosplenic axis in the development of fatal myocardial infarction

et al. 2023

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Aim. To compare data on the features of spleen macrophage composition in patients with fatal myocardial infarction (MI) and in patients from the control group without cardiovascular disease (CVD).Material and methods. The study included patients with fatal MI (n=30) and control group (n=5) — persons without CVD who died from injuries not compatible with life. Macrophage infiltration of spleen and myocardium fragments taken during autopsy was assessed by immunohistochemistry using macrophage markers CD68, CD163, CD206, stabilin-1.Results. There were following number of cells studied by us in the red pulp (RP) in patients with MI: CD163+, 906 (661; 1101), CD68+, 898 (807; 1049), stabilin-1+, 811 (531; 966), CD206+, 11 (9; 19); control group: CD163+, 400 (315; 513), CD68+, 40 (37; 45), stabilin-1+, 186 (107; 206), CD206+, 80 (70; 84). The content of all cells in the RP in patients with MI was high and prevailed over their number in the control group, while only the CD206+ concentration was inferior in number; in the control group, CD163+ cells predominated (p<0,05). There were following number of cells in the white pulp (WP): CD68+, 312 (260; 348), stabilin-1+, 59 (40; 123), CD163+, 29 (17; 56), CD206+, 2 (1; 5) in the group with MI; CD68+, 3 (1; 4), stabilin-1+, 3 (2; 3), CD163+, 23 (1; 48), CD206+, 1 (1; 2) in the control group. In persons with MI, CD68+ cells dominated in WP, while in the control group — CD163+ (p<0,05). The minimum and comparable in WP in both groups was the number of CD206+ cells (p<0,05), which correlated in the control group with the level of stabilin-1+ and CD206+ cells (r=-0,9, p=0,003) and in patients with MI — with the level of CD206+ cells in the myocardium (r=0,6, p=0,004).Conclusion. The dominance of CD163+ cells in all functional spleen areas in the control group and CD68+ cells in patients with MI was revealed. The only cell type, the content of which in the control group prevailed over that in MI in RP and correlated in WP with its myocardial concentration, was CD206+.

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Macrophages of the “Heart-Kidney” Axis: Their Dynamics and Correlations with Clinical Data and Outcomes in Patients with Myocardial Infarction

Cited by 7 publications

References 40 publications

Macrophages of the Cardiorenal Axis and Myocardial Infarction

Macrophages of the Cardiorenal Axis and Myocardial Infarction

Characteristics of the Cardiosplenic Axis in Patients with Fatal Myocardial Infarction

Place of the cardiosplenic axis in the development of fatal myocardial infarction

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