Macrophages in multiple myeloma: key roles and therapeutic strategies

Opperman, Khatora S.; Vandyke, Kate; Psaltis, Peter J.; Noll, Jacqueline E.; Zannettino, Andrew C.W.

doi:10.1007/s10555-020-09943-1

Cited by 12 publications

(9 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on RNA-sequencing data, immune cells infiltration and the populations of 22 different types of infiltrating immune cells were evaluated using CIBERSORT [ 26 ] algorithm (p < 0.05) (Fig. 4 ).…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, TAMs in the body are largely polarized to M2-like phenotypes in advanced stages of cancer [ 24 ]. Evidences showed that increased levels of M2 macrophages in bone marrow microenvironment were also revealed to tuomor progression and poor prognosis in MM [ 25 , 26 ]. Therefore, we have focused on the the relationship between macrophage and MM cells and selected M2 macrophage as our cell model in our verification study.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Integrative analysis identifies CXCL11 as an immune-related prognostic biomarker correlated with cell proliferation and immune infiltration in multiple myeloma microenvironment

et al. 2022

View full text Add to dashboard Cite

Purpose The interaction between tumor cells and tumor microenvironment (TME) has an important impact on progression and prognosis of multiple myeloma (MM), and has been proven to be promising therapeutic targets. This study intended to explore the relationship between TME and prognosis and identify valuable biomarkers of MM. Methods The transcriptomic and clinical information of MM retrieved from the Gene Expression Omnibus (GEO) were used to establish the model. The curve of Kaplan–Meier survival and the time-dependent receiver operating characteristic (ROC) were used to appraise the predictive ability. A nomogram was established for clinical application. Furthermore, the CIBERSORT algorithm was used to investigate the relation between IRGPI with the infiltration of immune cells. We also used histology, as well as in vitro and in vivo experiments to validate these findings. Results The results demonstrated an immune-related gene-based prognostic index (IRGPI) combined with clinical information. Patients were separated into high- and low-risk groups based on risk score, which had significantly difference in survival status and immune infiltrations. Furthermore, we identified CXCL11 as a key factor, which positively promotes the progression of MM and correlate with macrophage M2-like polarization and tumor immune cells infiltration. Conclusion Our findings suggest the IRGPI significantly demonstrate the differential prognosis and prediction of immune cells infiltration. It provides some insights into the complex interaction between myeloma tumor cells and the TME, as well as in the development of a novel biomarker target for anti-MM therapy.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Integrative analysis identifies CXCL11 as an immune-related prognostic biomarker correlated with cell proliferation and immune infiltration in multiple myeloma microenvironment

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Both M1 and M2 macrophages are highly plastic and can be interconverted in response to changes in the tumor microenvironment or therapeutic intervention. In recent years, a large amount of research evidence has demonstrated that macrophages have an essential role in the progression of MM, such as promoting BM PC homing and proliferation, angiogenesis, and angiogenic mimicry (46)(47)(48)(49). Macrophages in the blood effectively supported the proliferation of MM cell lines through contact-mediated and non-contact-mediated mechanisms, and contributed to the in vitro growth of primary CD138+ cells in the BM of MM patients.…”

Section: Tumor-associated Macrophagesmentioning

confidence: 99%

The yin–yang effects of immunity: From monoclonal gammopathy of undetermined significance to multiple myeloma

Liu

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

Multiple myeloma (MM) is the third most common malignant neoplasm of the hematological system. It often develops from monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) precursor states. In this process, the immune microenvironment interacts with the MM cells to exert yin and yang effects, promoting tumor progression on the one hand and inhibiting it on the other. Despite significant therapeutic advances, MM remains incurable, and the main reason for this may be related to the complex and variable immune microenvironment. Therefore, it is crucial to investigate the dynamic relationship between the immune microenvironment and tumors, to elucidate the molecular mechanisms of different factors in the microenvironment, and to develop novel therapeutic agents targeting the immune microenvironment of MM. In this paper, we review the latest research progress and describe the dual influences of the immune microenvironment on the development and progression of MM from the perspective of immune cells and molecules.

show abstract

“…Indeed, macrophages influence numerous pathways critical for the initiation and progression of MM including homing of malignant cells to BM, tumor cell growth and survival, drug resistance, angiogenesis, and immune suppression [ 52 ]. 1α,25(OH) 2 D 3 affects macrophage polarization towards the M2 phenotype [ 53 ]. Studies showed that VitD, by acting through its receptors, upregulates transcription of the anti-inflammatory dual-specificity protein phosphatase 1 (DUSP1) gene, which down-regulates the expression of inflammatory chemokine IL-8 produced by over-reactive (hyperinflammatory) macrophages ( Figure 1 ) [ 54 ].…”

Section: Vitamin D and The Immune Systemmentioning

confidence: 99%

“… Vitamin D actions on the cell compartment of the bone marrow microenvironment. Green arrows indicate the stimulating effects on expansion and function, while the red dashed arrows indicate the inhibition of proliferation and cell functions [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ]. …”

Section: Figurementioning

confidence: 99%

Reviewing the Significance of Vitamin D Substitution in Monoclonal Gammopathies

Innao

Allegra

Ginaldi

et al. 2021

IJMS

View full text Add to dashboard Cite

Vitamin D is a steroid hormone that is essential for bone mineral metabolism and it has several other effects in the body, including anti-cancer actions. Vitamin D causes a reduction in cell growth by interrupting the cell cycle. Moreover, the active form of vitamin D, i.e., 1,25-dihydroxyvitamin D, exerts various effects via its interaction with the vitamin D receptor on the innate and adaptive immune system, which could be relevant in the onset of tumors. Multiple myeloma is a treatable but incurable malignancy characterized by the growth of clonal plasma cells in protective niches in the bone marrow. In patients affected by multiple myeloma, vitamin D deficiency is commonly correlated with an advanced stage of the disease, greater risk of progression, the development of pathological fractures, and a worse prognosis. Changes in the vitamin D receptor often contribute to the occurrence and progress of deficiencies, which can be overcome by supplementation with vitamin D or analogues. However, in spite of the findings available in the literature, there is no clear standard of care and clinical practice varies. Further research is needed to better understand how vitamin D influences outcomes in patients with monoclonal gammopathies.

show abstract

Macrophages in multiple myeloma: key roles and therapeutic strategies

Cited by 12 publications

References 105 publications

Integrative analysis identifies CXCL11 as an immune-related prognostic biomarker correlated with cell proliferation and immune infiltration in multiple myeloma microenvironment

Integrative analysis identifies CXCL11 as an immune-related prognostic biomarker correlated with cell proliferation and immune infiltration in multiple myeloma microenvironment

The yin–yang effects of immunity: From monoclonal gammopathy of undetermined significance to multiple myeloma

Reviewing the Significance of Vitamin D Substitution in Monoclonal Gammopathies

Contact Info

Product

Resources

About