2019
DOI: 10.1002/2211-5463.12584
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Macrophages engulf apoptotic and primary necrotic thymocytes through similar phosphatidylserine‐dependent mechanisms

Abstract: One of the major roles of professional phagocytes is the removal of dead cells in the body. We know less about the clearance of necrotic cells than apoptotic cell phagocytosis, despite the fact that both types of dead cells need to be cleared together and necrotic cells appear often in pathological settings. In the present study, we examined phagocytosis of heat‐ or H 2 O 2 ‐killed necrotic and apoptotic thymocytes by mouse bone marrow‐derived macrophages ( … Show more

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Cited by 21 publications
(25 citation statements)
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References 49 publications
(71 reference statements)
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“…We verified that glial recognition of necrotic bodies occurred mainly via binding to phosphatidylserine (PS); competitive blocking of PS by Annexin V conjugate resulted in decreased NB uptake by 40-50% in all cell types, which is similar to previous reported data for macrophage internalization of cargo 30,37,39 . However, the molecular alterations at the plasma membrane by necrotic cells remain to be characterised.…”
Section: Discussionsupporting
confidence: 89%
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“…We verified that glial recognition of necrotic bodies occurred mainly via binding to phosphatidylserine (PS); competitive blocking of PS by Annexin V conjugate resulted in decreased NB uptake by 40-50% in all cell types, which is similar to previous reported data for macrophage internalization of cargo 30,37,39 . However, the molecular alterations at the plasma membrane by necrotic cells remain to be characterised.…”
Section: Discussionsupporting
confidence: 89%
“…In the current study, we investigated whether two types of peripheral glia, olfactory ensheathing cells (OECs) and Schwann cells (SCs), could recognize and engulf NBs. We compared this activity in the glia to that of macrophages, which are efficient at recognizing and phagocytosing NBs 30,[37][38][39] .…”
Section: Resultsmentioning
confidence: 99%
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“…Exosomes and MVs are shed from a variety of cell types and have been implicated in cell-cell communication 34 . ABs are formed during the apoptotic process and are then engulfed by macrophages and other immune cells 35,36 . Since exosomes are recognized as very tiny vesicles (<100 nm) 37,38 , it is likely that the OB-derived EVs isolated by FCM and visualized by confocal microscopy are mainly MVs and/or ABs rather than exosomes.…”
Section: Ob-derived Evs Promote Oc Differentiation Via Rankl Signalsmentioning
confidence: 99%