Macrophage Scavenger Receptors: Structure, Function and Tissue Distribution.

Takeya, Motohiro; Tomokiyo, Ryu Ichiro; Jinnouchi, Katsunori; Sakaguchi, Hisashi; Hagiwara, Sho Ichiro; Honda, Makoto; Wada, Youichiro; Suzuki, Hiroshi; Kodama, Tatsuhiko; Takahashi, Kiyoshi

doi:10.1267/ahc.32.47

Cited by 18 publications

(14 citation statements)

References 25 publications

(19 reference statements)

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“…It is reported that freshly isolated blood monocytes were negative for SRA 25 ; however, a few reports have indicated that SRA -monocytes can differentiate into SRA + cells in PB by various stimuli 32,33,34 . SRA + cells were observed in all control cases.…”

Section: Differentiation Of Sra + Cells In Pbmentioning

confidence: 99%

“…Scavenger receptor-mediated endocytosis of oxidized low-density lipoprotein by macrophages has been implicated in the pathogenesis of atherosclerosis. The differentiation of scavenger receptor A negative (SRA -) monocytes in peripheral blood (PB) into SRA positive (SRA + ) macrophages was believed to take place in atherosclerotic lesions by stimulation of macrophage-colony stimulating factor (M-CSF) [21][22][23][24] , and it was reported that freshly isolated blood monocytes were negative for SRA 25 . We surmised that plaque content might be exposed to the blood stream after disruption of plaque, and SRA -monocytes might differentiate into SRA + cells in PB by stimulation of M-CSF contained in plaque content, and that increased SRA + cells in PB might be a useful indication of disrupted, fissured or eroded plaque and coronary thrombus.…”

Section: Introductionmentioning

confidence: 99%

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Physiopathology of the Acute Coronary Syndromes

Emura¹

2012

Acute Coronary Syndromes

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Section: Differentiation Of Sra + Cells In Pbmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Physiopathology of the Acute Coronary Syndromes

Emura¹

2012

Acute Coronary Syndromes

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“…An anti-LDL antibody reacts with the endocytotic vesicles of the perivascular macrophage [17]. They are stained with an anti-scavenger receptor A antibody and contribute to the scavenger function [9,14,16,18,24].…”

Section: Introductionmentioning

confidence: 99%

Production of Polyclonal Antibodies against Perivascular Macrophages (Mato's FGP Cells) Isolated from Rat Brain Microvessels

Nakazawa

Morikawa

Nishikawa

et al. 2003

Acta Histochem. Cytochem

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Perivascular macrophages (Mato's perivascular cells) are located along microvessels in the Virchow-Robin space in mammals. We have isolated and cultured perivascular macrophages from microvessels in the cerebrum of Wistar strain male rats. The cultured cells were identified as perivascular macrophages in vivo. Polyclonal antibodies were produced by immunizing rabbits with cultured perivascular rat macrophages as antigens. The antibodies were evaluated by the immuno-fluorescence technique. These polyclonal antibodies reacted with perivascular macrophages, but not with perivascular smooth muscle cells or pericytes. The antibodies are, therefore, expected to be of use in studies on the immunological significance of perivascular macrophages, both in vivo and in vitro.

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“…They are called muscular macrophages and are categorized as a resident type [22]. In general the most common function of macrophages is phagocytosis and the presentation of digested antigens at their cell surface to induce immune responses and to activate other migratory immune cells [12,20,21]. Another important function is cytokine release to activate the immune response and alter the biological activities of surrounding cells.…”

Section: Introductionmentioning

confidence: 99%

Macrophages in Muscle Layer of Gastrointestinal Tract: Impairment of Muscle Contraction by Treatment with Lipopolysaccharide.

Torihashi

Hori

Ozaki

2001

Acta Histochem. Cytochem

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The morphology and function of resident macrophages in the muscle layer and in the subserosa of the gastrointestinal tract are described. FITC-dextran injected via the tail vein of a mouse or rat demonstrated a regular arrangement of macrophages on a whole mount preparation of the muscle layer. Electron microscopy revealed inactive phagocytosis under normal conditions. After a 4-8 hr incubation of rat ileal muscle with lipopolysaccharide (LPS) to investigate its effect on muscle contraction, macrophages began to express inducible nitric oxide synthase (iNOS) and released nitric oxide. This macrophage response was accompanied by the expression of cyclooxygenase-2 (COX-2) immunoreactivity and the production of prostaglandins. The muscarinic agonist-induced contractionwasgreatlyinhibitedbyLPStreatment, and this inhibition was reversed by either iNOS or COX-2 inhibitors. We concluded that one of the functions of muscular macrophages was the modulation of smooth muscle contraction under pathological conditions. The mechanism of iNOS upregulation indicated by our experiment is discussed.

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Macrophage Scavenger Receptors: Structure, Function and Tissue Distribution.

Cited by 18 publications

References 25 publications

Physiopathology of the Acute Coronary Syndromes

Physiopathology of the Acute Coronary Syndromes

Production of Polyclonal Antibodies against Perivascular Macrophages (Mato's FGP Cells) Isolated from Rat Brain Microvessels

Macrophages in Muscle Layer of Gastrointestinal Tract: Impairment of Muscle Contraction by Treatment with Lipopolysaccharide.

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