Macrophage Scavenger Receptor(s) and Oxidatively Modified Proteins in Endometriosis

Murphy, Ana A.; Palinski, Wulf; Rankin, Sara M.; Morales, Arlene J.; Parthasarathy, S.

doi:10.1016/s0015-0282(98)00088-0

Cited by 63 publications

(33 citation statements)

References 35 publications

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“…Increased oxidative processes lead to impairment of the mechanisms of antioxidant defence. The results presented also confirm the results of studies that showed decreased levels of superoxide dismutase, as well as vitamins C and E, in PF of women with endometriosis [12,15,14,29], and are consistent with the results obtained by Szczepanska et al [9] who demonstrated a decrease of the total antioxidant status of PF in endometriotic women. Previous research by the authors of the presented study [18] and a study by Ho et al [17], showed quite different results.…”

Section: Aaemsupporting

confidence: 92%

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Disrupted iron metabolism in peritoneal fluid may induce oxidative stress in the peritoneal cavity of women with endometriosis

Polak

Barczyński

Wertel

et al. 2018

Ann Agric Environ Med.

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Introduction and objective. Data on the possible role of peritoneal fluid free radical-mediated oxidative damage in the pathogenesis of endometriosis still remains inconsistent. The aim of the study was to determine iron metabolism markers and their influence on oxidative stress parameters in the peritoneal fluid of women with endometriosis. Materials and method. 110 women with endometriosis and 119 patients with benign ovarian cysts were included in the study. All visible peritoneal fluid was aspirated during laparoscopy from the anterior and posterior cul-de-sacs. under direct vision to avoid blood contamination. Haemoglobin, iron, total oxidative status, and total antioxidant status were measured using standard colourimetric kits. Results. Haemoglobin, iron levels, as well as total oxidative status values were significantly higher, whereas total antioxidant status values were significantly lower in the peritoneal fluid of patients with endometriosis, in comparison to the reference groups. No differences were observed in peritoneal fluid concentrations of all parameters measured in relation to the phase of the menstrual cycle. Conclusions. Peritoneal fluid of women with endometriosis is characterized by disrupted iron metabolism. This is most likely related to an increased number of erythrocytes in the peritoneal cavity of endometriotic women, which leads to a higher concentration of haemoglobin in this environment. Impaired iron homeostasis may have a significant influence on the pathophysiology of peritoneal endometriosis by the direct impact of haemoglobin derivatives and/or formation of the pro-inflammatory and pro-oxidative environment. Peritoneal cavity oxidative stress occurs predominantly in women in advanced stages of the disease.

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Section: Aaemsupporting

confidence: 92%

“…Completely opposite results were presented by Jackson et al [13]. Observations of PF vitamin E concentration are also inconsistent [14,15,16]. Szczepańska et al [9] demonstrated lower total antioxidant status in PF of infertile women with endometriosis.…”

Section: Introductionmentioning

confidence: 93%

Disrupted iron metabolism in peritoneal fluid may induce oxidative stress in the peritoneal cavity of women with endometriosis

Polak

Barczyński

Wertel

et al. 2018

Ann Agric Environ Med.

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“…Both endometriosis (Murphy et al, 1998) and atherosclerosis (De Villiers and Smart, 1999;Linton and Fazio, 2001) have tissue macrophages that express scavenger receptors and these macrophages are exposed to lipoproteins. Both atherosclerotic lesions and peritoneal fluid of women with endometriosis are characterized by the presence of macrophages, cytokines derived from macrophages, lipoproteins (LDL, HDL), T cells and cytokines derived from T cells, chemotactic factors for T cells as well as growth factors and oxidized LDL (Santanam et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Serum paraoxonase-1 activity in women with endometriosis and its relationship with the stage of the disease

2007

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BACKGROUND: There is increasing evidence that oxidative stress may play a role in the pathophysiology of endometriosis. Serum paraoxonase-1 (PON-1) is a high-density lipoprotein (HDL) associated enzyme that prevents oxidative modification of low-density lipoprotein (LDL). The aims of the study were to (i) compare the serum PON-1 activity in women with endometriosis versus controls and (ii) assess whether PON-1 activity can be used as a diagnostic test for endometriosis. METHODS: A total of 87 women who underwent laparoscopy or laparotomy were divided into groups by visual diagnosis at surgery: control patients (n 5 40) with no pathologic findings; endometriosis sufferers with minimal to mild (n 5 24) and moderate to severe (n 5 23) stage. Serum PON-1 activity was measured spectrophotometrically. Lipid hydroperoxide (LOOH) levels were measured by iodometric assay. Serum triglyceride (TG), total cholesterol (TC), HDL and LDL levels were also determined. RESULTS: PON-1 activity was significantly lower whereas LOOH levels were significantly higher in women with moderate to severe endometriosis than in women with minimal to mild endometriosis and controls, and in women with minimal to mild endometriosis compared with control groups (P < 0.0001, for all). A significant negative correlation was found between PON-1 activity and stage of the disease (r520.74, P < 0.0001). PON-1 activity and HDL levels were decreased whereas LOOH, TG, TC and LDL levels increased in all women with endometriosis versus controls (all P < 0.0001). CONCLUSIONS: Reduced serum PON-1 activity and increased LOOH might contribute to the increased susceptibility for the development of atherosclerosis. PON-1 activity can be used as a diagnostic test to detect endometriosis.

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“…They are modified forms of GnRH that bind to receptors in the pituitary but have a longer half-life than native GnRH and thereby in down-regulation of the pituitary-ovarian axis and hyperestrogenism, The treatment causes the ovaries to stop producing estrogen, which causes the endometriosis implants to shrink [25].Murphy et al whofound increased oxidation of low-density lipoprotein and increased concentrations of oxidized low-density lipoproteins in the peritoneal fluid in patients with pelvic endometriosis. Oxidative modification of these molecules involves peroxidation of the lipid component, which leads to release of aldehydes, such as malondialdeyde [26]. When oxidative stress was thought to be incriminated in endometriosis pathophysiology, antioxidants like vitamins (A, E, β-carotene, C and CoQ 10 ) were evaluated.Our result were in agreement with Szczepanskaet alwho reported that women with endometriosis had significantly lower levels of antioxidants than women without endometriosis, and significantly higher levels of lipid peroxides [27].A study by [28] reported that serum CoQ 10 levels were higher among postmenopausal than among premenopausal women, suggesting that circulating steroid hormone or gonadotropin concentrations may influence plasma levels of CoQ 10 .…”

Section: Discussionmentioning

confidence: 99%

Effect of Goserlin Acetate and Oxidative Stress in Iraqi Women with Recurrenceof Endometriosis

Naji¹,

Rubae'I²,

Turki³

2016

IOSR

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Macrophage Scavenger Receptor(s) and Oxidatively Modified Proteins in Endometriosis

Cited by 63 publications

References 35 publications

Disrupted iron metabolism in peritoneal fluid may induce oxidative stress in the peritoneal cavity of women with endometriosis

Disrupted iron metabolism in peritoneal fluid may induce oxidative stress in the peritoneal cavity of women with endometriosis

Serum paraoxonase-1 activity in women with endometriosis and its relationship with the stage of the disease

Effect of Goserlin Acetate and Oxidative Stress in Iraqi Women with Recurrenceof Endometriosis

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