Macrophage‐rich epithelioid angiosarcoma mimicking malignant melanoma

Brightman, Lori; Demierre, Marie‐France; Byers, H. Randolph

doi:10.1111/j.0303-6987.2006.00387.x

Cited by 23 publications

(23 citation statements)

References 14 publications

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“…EAS is a rare subtype of AS that histologically manifests itself quite differently from the classic AS and may mimic a carcinoma, adenocarcinoma or malignant melanoma. [26][27][28][29][30][31] Electron microscopic examination has revealed that the neoplastic cells possess a prominent cytoskeleton of intermediate filaments, numerous pinocytic vesicles, small intercellular lumina with microvilli on their surfaces and characteristic intracytoplasmic vacuoles. 32 In this case series, none of our patients presented with a lesion that was suggestive of a vascular origin clinically.…”

Section: Discussionmentioning

confidence: 99%

“…There is a male predominance and the prognosis is very poor. This variant serves as a high‐grade, diagnostically challenging neoplasm, as it may be difficult to be distinguished from the more common malignant melanoma or poorly differentiated carcinoma/metastatic carcinoma and adenocarcinoma 26–31 …”

mentioning

confidence: 99%

“…This variant serves as a high-grade, diagnostically challenging neoplasm, as it may be difficult to be distinguished from the more common malignant melanoma or poorly differentiated carcinoma/metastatic carcinoma and adenocarcinoma. [26][27][28][29][30][31] Materials and methods In all the patients who are presented below, the biopsy or excision specimens were fixed in 10% buffered formalin and processed routinely. The immunohistochemical testing was performed utilizing a standard streptavidin-biotin complex with peroxidase, done entirely in the BenchMark XT autostainer; Ventana Medical Systems Inc., Tucson, AZ, USA.…”

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confidence: 99%

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Cutaneous epithelioid angiosarcoma: a neoplasm with potential pitfalls in diagnosis

Mobini

2009

J Cutan Pathol

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Angiosarcoma (AS) is a rare neoplasm. Cutaneous AS is the most common form of AS. The epithelioid variant of the disease, however, is a rare entity. This subset can histologically mimic non-vascular neoplasms and impose serious challenges in reaching the correct diagnosis. We present five patients with cutaneous epithelioid angiosarcoma (EAS); in none, the clinical diagnosis included a vascular lesion. Three patients had history of breast conservation surgery with/without radiation therapy. Other patients had no previous radiation, and there was no lymphedema in any of the cases. The histopathological examination of the biopsy specimens by hematoxylin and eosin method was not suggestive of a malignant vascular neoplasm initially and the differential diagnoses included carcinoma, malignant melanoma and atypical lymphoid infiltrate. Only after performing immunohistochemical studies that included vascular markers, a definitive diagnosis was possible. Some cases showed unusual histopathological features. Cutaneous EAS is a rare variant of cutaneous AS that can mimic a variety of more common, non-vascular neoplasms, creating a major pitfall in the diagnosis. A careful and thorough histopathological examination and a high index of suspicion, along with appropriate immunohistochemical evaluation, can help reach a correct diagnosis and provide optimal patient care.

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Section: Discussionmentioning

confidence: 99%

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Cutaneous epithelioid angiosarcoma: a neoplasm with potential pitfalls in diagnosis

Mobini

2009

J Cutan Pathol

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“…Other primary sites that have been reported included skin, spleen, nervous system, gastrointestinal tract and bone. Case reports of angiosarcoma arising ovaries, prostate, adrenal gland, vagina and aorta have also been described [1][2][3][4][5][6][7]. Epithelioid angiosarcoma involving the lung is a rare disorder with low incidence, especially its primary form.…”

Section: Angiosarcomas Are a Type Of Malignant Vascular Tumour Characmentioning

confidence: 99%

Epithelioid Angiosarcoma of the Lung with Pleural Metastases: A Rare Cause of Haemoptysis

Carillo¹,

Carretero²,

Vázquez³

et al. 2010

Heart, Lung and Circulation

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“…In contrast to melanoma, epithelioid angiosarcoma is usually negative for more specific melanocytic markers and positive for endothelial markers (table 3). 60 – 62 In difficult cases, electron microscopy can be done to reveal some Weibel–Palade bodies.…”

Section: Malignant Dermal Mimicsmentioning

confidence: 99%

Non-melanocytic mimics of melanoma, part II: intradermal mimics

et al. 2008

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Intradermal melanoma diagnosis poses a great deal of confusion on many occasions since it can mimic almost any tumour within the dermis. In part I, the different features of intraepidermal mimics were discussed. In this part, there is discussion of the clinical, cytomorphological and immunohistochemical features of intradermal mimics of melanoma and how to distinguish these conditions from melanoma. There is also a description of the ultrastructural features of some of these conditions that may help to distinguish melanoma from its mimics. It is hoped that this approach, together with part I of the nonmelanocytic mimics of melanoma, will aid in better overall understanding of melanoma and its mimics.

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Macrophage‐rich epithelioid angiosarcoma mimicking malignant melanoma

Abstract: Macrophage-rich epithelioid angiosarcoma demonstrates abundant S-100 protein-positive epithelioid macrophages. This subset of epithelioid angiosarcoma may mimic malignant melanoma and may present as a pitfall in diagnosis.

Cited by 23 publications

References 14 publications

Cutaneous epithelioid angiosarcoma: a neoplasm with potential pitfalls in diagnosis

Cutaneous epithelioid angiosarcoma: a neoplasm with potential pitfalls in diagnosis

Epithelioid Angiosarcoma of the Lung with Pleural Metastases: A Rare Cause of Haemoptysis

Non-melanocytic mimics of melanoma, part II: intradermal mimics

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