Macrophage RGS12 contributes to osteoarthritis pathogenesis through enhancing the ubiquitination

Yuan, Gongsheng; Yang, Shuting

doi:10.1016/j.gendis.2021.08.005

Cited by 31 publications

(22 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yunyuan Zhang et al found that BMP2 represses the proliferation and growth of colorectal cancer cells 33 . GPCR proteins and their regulators/inhibitors are widely involved in numerous signaling pathways and biological processes such as in ammation, metabolism, and cancer [34][35][36][37][38][39][40][41][42][43][44][45][46] . Interestingly, WeiZhu et al found the G-proteincoupled receptor inhibitor pertussis toxin strongly suppressed BMP2 induction of osteogenic differentiation in C2C12 cells 47 .…”

Section: Discussionmentioning

confidence: 99%

Identification of key molecules and signaling pathways in GOLPH3 mediated colorectal cancer cells

Wang¹,

Wang²,

Wang

et al. 2022

Preprint

View full text Add to dashboard Cite

GOLPH3 is a peripheral membrane protein that is significantly associated with the development of cancer. However, the signaling pathways and mechanisms of GOLPH3 mediated cancer are still unclear. Here, our objective is to identify the essential molecules and signaling pathways by analyzing the RNA-seq data. The GSE196875 was produced by the Illumina NovaSeq 6000 (Homo sapiens). The KEGG and GO analyses indicated that axon guidance, signaling pathways regulating pluripotency of stem cells, and circadian entrainment are the major affected processes during the development of prostate cancer with GOLPH3 overexpression. Moreover, the ten interacting molecules were figured out including BMP2, RAC2, CACNA1C, PAX6, COL4A1, SPARC, GRIN1, CAV3, COL5A1, COL4A2. Thus, our study provides novel knowledge on the GOLPH3 affected cancer cells.

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of key molecules and signaling pathways in GOLPH3 mediated colorectal cancer cells

Wang¹,

Wang²,

Wang

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…The study by Michaël Cerezo et al found that there is a translational regulation of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma 21 . G protein-coupled receptors (GPCRs) and RGS are involved in the regulation of various biological processes including in ammation, metabolism, cell survival, proliferation, and migration [22][23][24][25][26][27][28][29][30][31][32][33] . Interestingly, Stéphane Pelletier et al found that GPCR agonists promote the tyrosine phosphorylation of STAT1 in a Rac-dependent manner 34 .…”

Section: Discussionmentioning

confidence: 99%

Genomic analyses identify signaling pathways and biological processes in small and large melanoma

Qian¹,

Chang²,

Zhang³

et al. 2022

Preprint

View full text Add to dashboard Cite

Melanoma is a skin malignancy that involves different signaling pathways with different sizes and phenotypes. However, the mechanism and function of small and large melanoma are unknown. Here, the aim of this study is to identify the functional molecules and signaling pathways by analyzing the RNA-seq data. The GSE164357 was created by the Illumina MouseWG-6 v2.0 expression bead chip. The KEGG and GO analyses indicated that Antigen processing and presentation and Phagosome are the main processes between the large and small melanoma. Moreover, we identified ten interactive molecules including STAT1, TTN, CALR, ACTA1, FN1, TNNT3, MYL1, TNNI2, RHOA, and TCAP. Therefore, our study may help to further understand the mechanism of melanoma.

show abstract

“…Our study showed that prostate cancer has the same phenotype as HSV-1 infection, suggesting that lactate may also activate cell death or immunity to limit cancer cells 23 . Numerous signaling pathways regulate the activities of G-protein-coupled receptors (GPCRs) [24][25][26] . GPCRs and Regulators of G protein signaling (RGS) proteins form a feedback loop to mediate the downstream molecules and signaling pathways [27][28][29][30][31][32][33][34][35][36] .…”

Section: Discussionmentioning

confidence: 99%

Identification of biological processes and signaling pathways in lactate-treated cancer cells

Qian

Chang

2022

Preprint

View full text Add to dashboard Cite

Cancer is a complex disease that involves the alterations of metabolic pathways and tumor microenvironment. Lactate in the tumor microenvironment leads to cancer proliferation, metastasis, and angiogenesis. However, the effect of lactate on prostate cancer cells is still unclear. Here, our objective is to identify the significant molecules and biological processes by analyzing the RNA-seq data. The GSE195639 was produced by the Illumina NextSeq 500 (Homo sapiens). The KEGG and GO analyses show that Herpes simplex virus 1 infection and Rap1 signaling pathway are considered major pathways during the lactate-treated cancer cells. Furthermore, we identified the top ten essential molecules including IL6, CASP3, JUN, MAPK3, BRCA1, PIK3R1, CCNA2, TPI1, APOE, and EXO1. Therefore, our study may provide novel insights into the mechanism of prostate cancers.

show abstract

Macrophage RGS12 contributes to osteoarthritis pathogenesis through enhancing the ubiquitination

Cited by 31 publications

References 37 publications

Identification of key molecules and signaling pathways in GOLPH3 mediated colorectal cancer cells

Identification of key molecules and signaling pathways in GOLPH3 mediated colorectal cancer cells

Genomic analyses identify signaling pathways and biological processes in small and large melanoma

Identification of biological processes and signaling pathways in lactate-treated cancer cells

Contact Info

Product

Resources

About