Macrophage reprogramming: Influence of latex beads with various functional groups on macrophage phenotype and phagocytic uptake<i>in vitro</i>

Akilbekova, Dana; Philiph, Rachel; Graham, Ailish M.; Bratlie, Kaitlin M.

doi:10.1002/jbm.a.35169

Cited by 47 publications

(40 citation statements)

References 32 publications

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“…The potential beneficial use of biomaterials and their effect on wound macrophages in drug delivery and tissue engineering merits further investigation . For example, there is little evidence that explores that effect of polarization after synthetic or naturally derived biomaterials are implanted in the wound …”

Section: The Use Of Macrophages In Clinical Practicementioning

confidence: 99%

Macrophages: A review of their role in wound healing and their therapeutic use

Snyder

Lantis

Kirsner

et al. 2016

Wound Repair Regeneration

190

121

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Macrophages are mononuclear phagocytes established during embryogenesis and derived from the yolk sac or the fetal liver but also recruited from the blood and bone marrow under proliferative inflammatory conditions (such as tissue repair). Most importantly, they take on distinct phenotypes and functions crucial to healing upon localization in the wound. The objective of this review is to summarize recent findings in regard to the cellular mechanisms of macrophages and chronic wounds. Advances in the potential use of macrophage therapy have arisen based, in part, on the fact that early recruitment of macrophages is critical to wound healing. Higher quality evidence is needed to support the use of macrophage therapy for chronic wound types, as is a better understanding of the signaling related to macrophage polarization, activation of macrophages, and their effect of mechanisms of repair. An evaluation of the currently available research on mechanism of action may lead to a better understanding of the signaling processes of the many macrophage phenotypes, as well as their roles and outcomes in wound healing, which could then guide the development and eventual widespread use of macrophage therapies.

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Section: The Use Of Macrophages In Clinical Practicementioning

confidence: 99%

Macrophages: A review of their role in wound healing and their therapeutic use

Snyder

Lantis

Kirsner

et al. 2016

Wound Repair Regeneration

190

121

View full text Add to dashboard Cite

show abstract

“…Macrophages are considered to be functionally heterogeneous cells with different phenotypes representing distinct sublineages [1,2]. The heterogeneity of these cells is attributed to their location in the tissue, due to microenvironmental signals that control the functional phenotype [1,[3][4][5]. In the presence of specific microenviromental signals, macrophages are able to switch from one phenotype to another, indicating that these cells have a degree of plasticity in addition to heterogeneity [3,6].…”

Section: Heterogeneity Of Macrophagesmentioning

confidence: 99%

The significance of macrophage phenotype in cancer and biomaterials

Bygd¹,

Forsmark²,

Bratlie³

2014

Clinical & Translational Med

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Macrophages have long been known to exhibit heterogeneous and plastic phenotypes. They show functional diversity with roles in homeostasis, tissue repair, immunity and disease. There exists a spectrum of macrophage phenotypes with varied effector functions, molecular determinants, cytokine and chemokine profiles, as well as receptor expression. In tumor microenvironments, the subset of macrophages known as tumor-associated macrophages generates byproducts that enhance tumor growth and angiogenesis, making them attractive targets for anti-cancer therapeutics. With respect to wound healing and the foreign body response, there is a necessity for balance between pro-inflammatory, wound healing, and regulatory macrophages in order to achieve successful implantation of a scaffold for tissue engineering. In this review, we discuss the multitude of ways macrophages are known to be important in cancer therapies and implanted biomaterials. Electronic supplementary material The online version of this article (doi:10.1186/s40169-014-0041-2) contains supplementary material, which is available to authorized users.

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“…M1 macrophages may control Candida infection through phagocytosis and also induction of inflammation in the skin by producing inflammatory cytokines, such as tumour necrosis factor alpha (TNF α ) [6–8]. M2 macrophages may also kill Candida by phagocytosis, but, importantly, can also produce anti-inflammatory cytokines and growth factors leading to immune tolerance to Candida [1, 9]. …”

Section: Introductionmentioning

confidence: 99%

IL-34 SuppressesCandida albicansInduced TNFαProduction in M1 Macrophages by Downregulating Expression of Dectin-1 and TLR2

Sun²,

Williams

et al. 2015

Journal of Immunology Research

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Candida albicans is a fungus that is an opportunistic pathogen of humans. Normally, C. albicans exists as a harmless commensal and does not trigger inflammatory responses by resident macrophages in skin mucosa, which may be caused by a tolerance of skin macrophage to C. albicans. IL-34 is a recently discovered cytokine, constitutively expressed by keratinocytes in the skin. IL-34 binds to the receptor of M-CSF, thereby stimulating tissue macrophage maturation and differentiation. Resident macrophages exhibit phenotypic plasticity and may transform into inflammatory M1 macrophages for immunity or anti-inflammatory M2 macrophages for tissue repair. M1 macrophages produce higher levels of inflammatory cytokines such as TNFα in response to C. albicans stimulation. In this study, it was demonstrated that IL-34 attenuated TNFα production by M1 macrophages challenged with heat killed Candida (HKC). The molecular mechanism of IL-34 mediated suppression of HKC induced TNFα production by M1 macrophages was by the inhibition of M1 macrophage expression of key C. albicans pattern recognition receptors (PPRs), namely, Toll-like receptor (TLR) 2 and Dectin-1. The results of this study indicated that constitutive IL-34 expressed by skin keratinocytes might suppress resident macrophage responses to C. albicans colonisation by maintaining low levels TLR2 and Dectin-1 expression by macrophages.

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Macrophage reprogramming: Influence of latex beads with various functional groups on macrophage phenotype and phagocytic uptakein vitro

Cited by 47 publications

References 32 publications

Macrophages: A review of their role in wound healing and their therapeutic use

Macrophages: A review of their role in wound healing and their therapeutic use

The significance of macrophage phenotype in cancer and biomaterials

IL-34 SuppressesCandida albicansInduced TNFαProduction in M1 Macrophages by Downregulating Expression of Dectin-1 and TLR2

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