Macrophage migration inhibitory factor promotes the migration of dendritic cells through CD74 and the activation of the Src/PI3K/myosin II pathway

Ives, Annette; Roy, Didier Le; Théroude, Charlotte; Bernhagen, Jürgen; Roger, Thierry; Calandra, Thierry

doi:10.1096/fj.202001605r

Cited by 28 publications

(23 citation statements)

References 88 publications

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“…Some of them have already been reported. For instance, the roles of PROS1-AXL (34), LAT-TNFRSF1B (35), ANXA1-FPR1 (36,37), MIF-CD74 (38)(39)(40), SPP1-CD44 (41), VEGFB-VEGFR (42), IL6-IL6R (43), and OSM-OSMR (44) have been confirmed in macrophage activation in GBM. Additionally, more novel combinations are first proposed in this work, including TRAIL signaling pathway (TNFSF10-TNFRSF10B), TWEAK signaling pathway (TNFSF12-TNFRSF12A), VISFATIN signaling pathway (NAMPT-(ITGA5+OTGB1)), ncWNT signaling pathway (WNTSA-FZD3), PARs signaling pathway (PRSS3-F2R), and RESISTIN signaling pathway (RETN-CAP1).…”

Section: Discussionmentioning

confidence: 99%

Ferroptosis Activation Scoring Model Assists in Chemotherapeutic Agents’ Selection and Mediates Cross-Talk With Immunocytes in Malignant Glioblastoma

et al. 2022

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Gliomas are aggressive tumors in the central nervous system and glioblastoma is the most malignant type. Ferroptosis is a programmed cell death that can modulate tumor resistance to therapy and the components of tumor microenvironment. However, the relationship between ferroptosis, tumor immune landscape, and glioblastoma progression is still elusive. In this work, data from bulk RNA-seq analysis, single cell RNA-seq analysis, and our own data (the Xiangya cohort) are integrated to reveal their relationships. A scoring system is constructed according to ferroptosis related gene expression, and high scoring samples resistant to ferroptosis and show worse survival outcome than low scoring samples. Notably, most of the high scoring samples are aggressive glioblastoma subtype, mesenchymal, and classical, by calculating RNA velocity. Cross-talk between high scoring glioblastoma cells and immunocytes are explored by R package ‘celltalker’. Ligand–receptor pairs like the TRAIL or TWEAK signaling pathway are identified as novel bridges implying how ferroptosis modulate immunocytes’ function and shape tumor microenvironment. Critically, potential drugs target to high scoring samples are predicted, namely, SNX2112, AZ628, and bortezomib and five compounds from the CellMiner database. Taken together, ferroptosis associates with glioblastoma aggressiveness, cross-talk with immunocytes and offer novel chemotherapy strategy.

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Section: Discussionmentioning

confidence: 99%

Ferroptosis Activation Scoring Model Assists in Chemotherapeutic Agents’ Selection and Mediates Cross-Talk With Immunocytes in Malignant Glioblastoma

et al. 2022

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“…CD74 was characterized as a cell surface receptor for the macrophage migration inhibitory factor (MIF, [ 70 , 71 ]). The binding of MIF to CD74 leads to an increased recruitment of macrophages and dendritic cells [ 72 ]. In cell culture experiments, microglia treated with MIF showed a significant decrease in interferon-γ (IFNγ) expression.…”

Section: Cd74mentioning

confidence: 99%

Beyond Activation: Characterizing Microglial Functional Phenotypes

Lier

Streit

Bechmann

2021

Cells

120

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Classically, the following three morphological states of microglia have been defined: ramified, amoeboid and phagocytic. While ramified cells were long regarded as “resting”, amoeboid and phagocytic microglia were viewed as “activated”. In aged human brains, a fourth, morphologically novel state has been described, i.e. dystrophic microglia, which are thought to be senescent cells. Since microglia are not replenished by blood-borne mononuclear cells under physiological circumstances, they seem to have an “expiration date” limiting their capacity to phagocytose and support neurons. Identifying factors that drive microglial aging may thus be helpful to delay the onset of neurodegenerative diseases, such as Alzheimer’s disease (AD). Recent progress in single-cell deep sequencing methods allowed for more refined differentiation and revealed regional-, age- and sex-dependent differences of the microglial population, and a growing number of studies demonstrate various expression profiles defining microglial subpopulations. Given the heterogeneity of pathologic states in the central nervous system, the need for accurately describing microglial morphology and expression patterns becomes increasingly important. Here, we review commonly used microglial markers and their fluctuations in expression in health and disease, with a focus on IBA1 low/negative microglia, which can be found in individuals with liver disease.

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“…Cell migration was assessed using Corning Costar Transwell ® cell culture inserts with 5 mM pore size (Corning B.V. Life Sciences, Amsterdam, NL) as described previously (32). Briefly, 3 x 10 5 PMNs were resuspended in HBSS medium (Invitrogen) containing 0.1% BSA (Sigma-Aldrich, Buchs, Switzerland) and transferred to the transwell inserts.…”

Section: Migration Assaymentioning

confidence: 99%

Trained Immunity Confers Prolonged Protection From Listeriosis

et al. 2021

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Trained immunity refers to the ability of the innate immune system exposed to a first challenge to provide an enhanced response to a secondary homologous or heterologous challenge. We reported that training induced with β-glucan one week before infection confers protection against a broad-spectrum of lethal bacterial infections. Whether this protection persists over time is unknown. To tackle this question, we analyzed the immune status and the response to Listeria monocytogenes (L. monocytogenes) of mice trained 9 weeks before analysis. The induction of trained immunity increased bone marrow myelopoiesis and blood counts of Ly6Chigh inflammatory monocytes and polymorphonuclear neutrophils (PMNs). Ex vivo, whole blood, PMNs and monocytes from trained mice produced increased levels of cytokines in response to microbial products and limited the growth of L. monocytogenes. In vivo, following challenge with L. monocytogenes, peripheral blood leukocytes were massively depleted in control mice but largely preserved in trained mice. PMNs were reduced also in the spleen from control mice, and increased in the spleen of trained mice. In transwell experiments, PMNs from trained mice showed increased spontaneous migration and CXCL2/MIP2α-induced chemotaxis, suggesting that training promotes the migration of PMNs in peripheral organs targeted by L. monocytogenes. Trained PMNs and monocytes had higher glycolytic activity and mitochondrial respiration than control cells when exposed to L. monocytogenes. Bacterial burden and dissemination in blood, spleen and liver as well as systemic cytokines and inflammation (multiplex bead assay and bioluminescence imaging) were reduced in trained mice. In full agreement with these results, mice trained 9 weeks before infection were powerfully protected from lethal listeriosis. Altogether, these data suggest that training increases the generation and the antimicrobial activity of PMNs and monocytes, which may confer prolonged protection from lethal bacterial infection.

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Macrophage migration inhibitory factor promotes the migration of dendritic cells through CD74 and the activation of the Src/PI3K/myosin II pathway

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 28 publications

References 88 publications

Ferroptosis Activation Scoring Model Assists in Chemotherapeutic Agents’ Selection and Mediates Cross-Talk With Immunocytes in Malignant Glioblastoma

Ferroptosis Activation Scoring Model Assists in Chemotherapeutic Agents’ Selection and Mediates Cross-Talk With Immunocytes in Malignant Glioblastoma

Beyond Activation: Characterizing Microglial Functional Phenotypes

Trained Immunity Confers Prolonged Protection From Listeriosis

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