Macrophage Migration Inhibitory Factor Gene Polymorphism is Associated with Psoriasis

Donn, Rachelle; Plant, Darren; Jury, Francine; Richards, Helen L.; Worthington, Jane; Ray, David; Griffiths, C.E.M.

doi:10.1111/j.0022-202x.2004.23314.x

Cited by 79 publications

(72 citation statements)

References 31 publications

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“…This haplotype has been found to be associated with juvenile idiopathic arthritis (JIA), 16 rheumatoid arthritis (RA) 17 and psoriasis. 18 The allele frequencies found in the Spanish population are similar to those reported in other white population from North America and Europe, 14 and differ significantly from those observed in other populations of different ethnic origin. 19,20 Variations in the distribution of MIF alleles among racial groups may suggest the existence of selective pressure acting on the MIF locus.…”

Section: Resultssupporting

confidence: 76%

“…22 In yet other studies, association of MIF with susceptibility to JIA and psoriasis is not restricted to the most severe clinical subgroups. 16,18 These observations suggest that the MIF gene may be associated with predisposition rather than with severity. These discrepancies could be explained, at least in part, by the small sample size of some clinical subgroups resulting in the lack of power to detect an association.…”

Section: Resultsmentioning

confidence: 97%

“…MIF CATT repeats genotyping was carried out by PCR using a primer labeled with a fluorescent dye as previously described. 18 In brief, we used the following primers: 5 0 -TTG CAC CTA TCA GAG ACC-3 0 as forward primer 5 0 labeled with 6-FAM and 5 0 -TCC ACT AAT GGT AAA CTC G-3 0 as reverse. After capillary electrophoresis on an automated DNA sequencer (ABI Prism 3100 Genetic Analyzer, Applied Biosystems), alleles of the CATT repeat element were identified using Genotyper 3.7 software (Applied Biosystems).…”

Section: Resultsmentioning

confidence: 99%

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Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus

et al. 2006

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The aim of this study was to evaluate the potential association of functional polymorphisms of macrophage migration inhibitory factor with systemic lupus erythematosus. Our study includes 711 systemic lupus erythematosus (SLE) patients and 755 healthy controls. We genotyped the migration inhibitory factor (MIF) À173G/C using a polymerase chain reaction (PCR) system with predeveloped TaqMan allelic discrimination assay and the MIF À794 CATT n microsatellite polymorphism using a PCR-fluorescent method. A statistically significant difference in the distribution of the MIF À173*C allele between SLE patients and controls (P ¼ 0.004, OR ¼ 1.34, 95% CI ¼ 1.05-1.27) was observed. In addition, the frequency of the MIF À173 *C/C genotype was higher in SLE patient (P ¼ 0.002, OR ¼ 2.58, 95% CI ¼ 1.32-5.10). No differences in the distribution of CATT n were found. However, the haplotypes analyses showed that only the CATT 7 -MIF À173 *C haplotype was associated with a higher susceptibility to SLE (P ¼ 0.001, OR 1.84, 95% CI 1.35-2.79). No association with clinical features was detected in any case. These results suggest that both, MIF À173 *C allele and CATT 7 -MIF À173*C haplotype, confer susceptibility to SLE in our population.

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Section: Resultssupporting

confidence: 76%

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

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Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus

et al. 2006

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“…The genotyping of the MIF Ϫ173GϾC and CATT [5][6][7][8] polymorphisms was performed using essentially the same protocols as described recently by Donn et al (4).…”

Section: Methodsmentioning

confidence: 99%

Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor

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et al. 2005

Arthritis & Rheumatism

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Objective. To study whether genetic variants of macrophage migration inhibitory factor (MIF), the MIF ؊173G>C and CATT 5-8 alleles, are associated with disease severity and levels of circulating MIF in patients with rheumatoid arthritis (RA).Methods. Genotyping was performed in patients with early RA and in healthy controls. Demographic data, disease activity, and outcome measurements were compared between patients with and without the MIF variants. MIF ؊173G>C and CATT 5-8 polymorphisms were genotyped, and a newly developed enzyme-linked immunosorbent assay for human MIF was used. Allele and genotype distributions of the MIF ؊173G>C and CATT 5-8 polymorphisms were compared between patients and controls by chi-square test. Multiple regression analysis was performed to assess the independence of the MIF functional genetic variants as risk factors for radiologic joint damage.Results. Genotyping of the ؊173G>C and CATT 5-8 polymorphisms of MIF in RA patients and healthy individuals (n ‫؍‬ 277 each) revealed similar frequencies of genotypes and haplotypes in both groups. No significant differences in demographic or clinical features were observed between RA patients carrying the MIF ؊173C allele or the MIF CATT 7 allele or both and noncarrier RA patients. Radiologic joint damage was significantly higher in patients carrying risk alleles of the MIF ؊173G>C or the MIF CATT 5-8 functional variants. No synergistic effects between both genetic variants were observed. Multivariate regression analysis revealed that presence of the MIF ؊173C/C and MIF CATT 7/7 genotypes and having 1 MIF ؊173C allele were independent prognostic variables. Carriership of the MIF ؊173C allele (P ‫؍‬ 0.002) or MIF CATT 7 allele (P ‫؍‬ 0.004) was associated with significantly higher circulating MIF levels compared with those in subjects having none of the risk-conferring alleles, and greater circulating MIF levels correlated with more severe radiologic joint damage (r ‫؍‬ 0.64, P ‫؍‬ 0.001).Conclusion. The MIF polymorphisms are not associated with RA susceptibility but are associated with high levels of radiologic joint damage. High circulating MIF levels were shown to correlate strongly with radiologic joint damage, suggesting that MIF expression is genetically determined and can be used as a novel prognostic tool in RA.

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“…Both the polymorphism and haplotypes of the two polymorphisms were also associated with atopy and psoriasis. 13,14 These polymorphisms affect MIF promoter activity in vitro. 11,15 Here, we document the significant associations between MIF gene polymorphism and obesity in Japanese.…”

Section: Introductionmentioning

confidence: 99%

Promoter polymorphism in the macrophage migration inhibitory factor gene is associated with obesity

et al. 2005

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Objective: To explore the association of promoter polymorphisms of macrophage migration inhibitory factor (MIF) gene with obesity. Subjects: In total, 213 nondiabetic Japanese subjects. They were divided into three groups according to World Health Organization definitions: lean (body mass index (BMI) o25 kg/m 2 ), overweight (25pBMIo30 kg/m 2 ) and obese (BMIX30 kg/m 2 ). Methods: We examined two polymorphic loci in the MIF gene in the subjects: a single-nucleotide polymorphism at position À173 (G/C) and a CATT-tetranucleotide repeat polymorphism at position À794, which both can affect promoter activity in different cells. Results: We detected four alleles: 5-, 6-, 7-and 8-CATT at position À794. Genotypes without the 5-CATT allele (X/X, X refers to 6-, 7-or 8-CATT alleles) were more common in obese subjects than in lean or overweight groups (P ¼ 0.013). The X-CATT allele was more frequent in obese subjects than in lean or overweight subjects (P ¼ 0.030). In contrast, À173G/C was not associated with obesity. Among the haplotypes of the two promoter polymorphisms, G/5-CATT ((À173G/C)/(À794[CATT] 5-8 )) was associated with a decreased risk of obesity (P ¼ 0.025) and G/6-CATT with an increased risk of overweight (P ¼ 0.028). Conclusion: Promoter polymorphism in the MIF gene is linked with obesity.

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Macrophage Migration Inhibitory Factor Gene Polymorphism is Associated with Psoriasis

Cited by 79 publications

References 31 publications

Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus

Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus

Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor

Promoter polymorphism in the macrophage migration inhibitory factor gene is associated with obesity

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