Macrophage migration inhibitor factor (MIF): Potential role in cognitive impairment disorders

A comprehensive review on the progress and challenges of tetrahydroisoquinoline derivatives as a promising therapeutic agent to treat Alzheimer's disease

“…NO is neurotoxic, as it is endogenously produced from NADPH, l -arginine, and oxygen under proinflammatory stimuli [ 115 ]. As a result, the macrophage produces proinflammatory cytokines, including IL-6, IL-1β, and TNF-α, that deteriorate cognitive function and neuron viability [ 116 ]. Interestingly, the administration of 15 μM 3b and 3c significantly reduced LPS-induced NO production, with the inhibition by 3b being more substantial than 3c.…”