Macrophage metabolism reprogramming EGCG-Cu coordination capsules delivered in polyzwitterionic hydrogel for burn wound healing and regeneration

Li, Qinghua; Song, Huijuan; Li, Shuangyang; Hu, Peng-bo; Zhang, Chuangnian; Ju, Zhang; Feng, Zujian; Huang, Pingsheng

doi:10.1016/j.bioactmat.2023.07.011

Cited by 13 publications

(10 citation statements)

References 64 publications

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“…aureus on the surfaces of all HA-CB hydrogels, verifying their excellent resistance to bacteria (Figure d,e). The resistance of hydrogels to cells could prevent the occurrence of adhesion to damaged tissue, reducing the pain of replacement and causing thorny problems. − Herein, L929 cells were used to evaluate the prevention of HA-CB hydrogels for fibroblast adhesion; hydrogels and L929 cells were incubated in 48-well plates for 12 and 24 h. Similar to the principle of anti-protein adhesion, the hydration layer on the surface of HA-CB hydrogel prevented the adhesion of proteins secreted by cells, and L929 cells were suspended in the cell culture medium and gradually apoptotic . Over time, L929 cells on TCPS showed an obvious proliferation and differentiation tendency, whereas only a few spherical dead cells still adhered to the surface of hydrogels, and the fluorescence intensity detected on the surface of hydrogel was significantly weaker than that of TCPS, showing good stability in anti-cell adhesion (Figure f,g).…”

Section: Resultsmentioning

confidence: 99%

Self-Adhesive, Strong Antifouling, and Mechanically Reinforced Methacrylate Hyaluronic Acid Cross-Linked Carboxybetaine Zwitterionic Hydrogels

Wang,

Ren,

Zhang

et al. 2023

Biomacromolecules

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Hyaluronic acid and zwitterionic hydrogels are soft materials with poor mechanical properties. The unique structures and physiological properties make them attractive candidates for ideal hydrogel dressings, but the crux of lacking satisfying mechanical strengths and adhesive properties is still pendent. In this study, the physical cross-linking of dipole−dipole interactions of zwitterionic pairs was utilized to enhance the mechanical properties of hydrogels. The hydrogels have been prepared by copolymerizing methacrylate hyaluronic (HAGMA) with carboxybetaine methacrylamide (CBMAA) (the mass ratio of [HAGMA]/[CBMAA] is 2:5, 1:5, 1:10, or 1:20), obtaining HA-CB 2.5 , HA-CB 5.0 , HA-CB 10.0 , or HA-CB 20.0 hydrogel. Therein, the HA-CB 20.0 hydrogel with a high CBMAA content can generate a strong dipole−dipole interaction to form internal physical cross-links, exhibit stretchability and low elastic modulus, and withstand 99% compressive deformation and cyclic compression under strain at 90%. Moreover, the HA-CB 20.0 hydrogel is adhesive to diverse substrates, including skin, glass, stainless steel, and plastic. The synergistic effect of HAGMA and CBMAA shows strong antibiofouling, high water absorption, biodegradability under hyaluronidase, and biocompatibility.

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Section: Resultsmentioning

confidence: 99%

Self-Adhesive, Strong Antifouling, and Mechanically Reinforced Methacrylate Hyaluronic Acid Cross-Linked Carboxybetaine Zwitterionic Hydrogels

Wang,

Ren,

Zhang

et al. 2023

Biomacromolecules

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“…In this prospective, a wide variety of wound dressings, such as hydrogels, 51 microporous scaffolds, 52 films 53 and nanofibrous matrices 54 have been developed and even commercialized. Of them, hydrogel‐based systems have gained prominence in the field of wound dressing materials due to their advantageous properties, including exceptional absorbency, porous structure, tunable mechanical strength and biocompatibility 51 . Various types of natural and synthetic hydrogels have been employed as delivery systems, safeguarding bioactive molecules from proteolytic degradation.…”

Section: Discussionmentioning

confidence: 99%

“…Typically, to expedite wound healing especially chronic wounds, introducing a favourable environment involves the application of functional biomaterials that possess biocompatibility, low allergenicity, reduced immune responses, facilitating a conducive setting. 49 , 50 In this prospective, a wide variety of wound dressings, such as hydrogels, 51 microporous scaffolds, 52 films 53 and nanofibrous matrices 54 have been developed and even commercialized. Of them, hydrogel‐based systems have gained prominence in the field of wound dressing materials due to their advantageous properties, including exceptional absorbency, porous structure, tunable mechanical strength and biocompatibility.…”

Section: Discussionmentioning

confidence: 99%

“…Of them, hydrogel‐based systems have gained prominence in the field of wound dressing materials due to their advantageous properties, including exceptional absorbency, porous structure, tunable mechanical strength and biocompatibility. 51 Various types of natural and synthetic hydrogels have been employed as delivery systems, safeguarding bioactive molecules from proteolytic degradation. Additionally, hydrogel dressings have been extensively investigated for their capacity to address excessive inflammation during the wound healing process.…”

Section: Discussionmentioning

confidence: 99%

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Visualization of the relationship between macrophage and wound healing from the perspective of bibliometric analysis

Guo,

Li,

Xie

et al. 2023

International Wound Journal

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Macrophages play a crucial role in aiding all phases of the wound‐healing process and has garnered increasing attention recently. Although a substantial body of related studies has been published, there remains a lack of comprehensive bibliometric analysis. In this study, we collected 4296 papers from the Web of Science Core Collection database. Three tools including CiteSpace, VOSviewer and one online analytical platform were employed to conduct bibliometric analysis and data visualization. Our results revealed that the annual number of publications related to macrophage and wound healing has increased exponentially with the year. The United States and China stand as the primary driving forces within this field, collectively constituting 58.2% of the total publication output. The application of biomaterials was one of the most concerned research areas in this field. According to references analysis, the current research focus has shifted to diabetic wound healing and regulating macrophage polarization. Based on the keywords analysis, we identified the following research frontiers in the future: exosomes and other extracellular vesicles; bio‐derived materials and drug delivery methods such as nanoparticles, scaffolds and hydrogels; immunomodulation and macrophage polarization in the M2‐state; chronic wounds, particularly those associated with diabetes; antimicrobial peptides; and antioxidant. Additionally, TNF, IL‐6, IL‐10, TGF‐β1 and VEGF ranked as the five genes that have garnered the most research attention in the intersection of macrophage and wound healing. All in all, our findings offered researchers a holistic view of the ongoing progress in the field of macrophages and wound healing, serving as a valuable reference for scholars and policymakers in this domain.

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“…Furthermore, great efforts have been spared for a synergistic antibacterial effect. According to previous reported studies, copper-based nanoagents with exceptional biocompatibility and efficacious sterilization have attracted substantial attention in wound healing. , Of particular interest is the utilization of Cu 2+ , as it has been demonstrated to stimulate angiogenesis, accelerate the proliferation and migration of keratinocyte, and boost collagen deposition that prominently led to the amplification of the wound healing effect. , However, because of the microporous structure of the reported hydrogels, it remains a daunting challenge to quickly and uniformly anchor Cu 2+ in wound dressing.…”

Section: Introductionmentioning

confidence: 99%

In Situ Formation of Hydrogel Wound Dressing Based on Carboxymethyl Chitin/Tannic Acid for Promoting Skin Wound Healing

Lin,

Li,

Ying

et al. 2024

ACS Omega

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Triggering the healing process of drug-resistant bacteria-infected wounds has attracted great attention due to global morbidity that may induce gangrene, amputation, and even death. Here, a chitin derivative, carboxymethyl chitosan (CMC), tannic acid (TA), and Cu2+ were used for hydrogel engineering. Using sodium bicarbonate as the neutralizer and reductant, hydrogen bonds between CMC and TA and in situ Cu(OH)2 generation via ion coordination force between Cu2+ and TA facilitated the synthesis of CMC/TA/Cu hydrogel. Cu2+ and TA release, cytotoxicity, in vitro cell migration, angiogenesis, and antidrug-resistant bacteria were measured. Besides, wound closure was evaluated in vivo using the methicillin-resistant Staphylococcus aureus (MRSA)-infected excisional dermal wound mouse model. Negligible toxicity was observed both in vitro and in vivo. Dermal cell migration and angiogenesis were significantly enhanced. In vivo, the CMC/TA/Cu hydrogel induced effective re-epithelialization, collagen deposition, inflammatory alleviation, and MRSA inhibition during wound repair in mice. All these results confirmed that the CMC/TA/Cu hydrogel is a promising novel dressing for chronic wound healing in clinic.

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Macrophage metabolism reprogramming EGCG-Cu coordination capsules delivered in polyzwitterionic hydrogel for burn wound healing and regeneration

Cited by 13 publications

References 64 publications

Self-Adhesive, Strong Antifouling, and Mechanically Reinforced Methacrylate Hyaluronic Acid Cross-Linked Carboxybetaine Zwitterionic Hydrogels

Self-Adhesive, Strong Antifouling, and Mechanically Reinforced Methacrylate Hyaluronic Acid Cross-Linked Carboxybetaine Zwitterionic Hydrogels

Visualization of the relationship between macrophage and wound healing from the perspective of bibliometric analysis

In Situ Formation of Hydrogel Wound Dressing Based on Carboxymethyl Chitin/Tannic Acid for Promoting Skin Wound Healing

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