2024
DOI: 10.1096/fj.202302001r
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Macrophage mediators and mechanisms in cardiovascular disease

Patrik Schelemei,
Elena Wagner,
Felix Simon Ruben Picard
et al.

Abstract: Macrophages are major players in myocardial infarction (MI) and atherosclerosis, two major cardiovascular diseases (CVD). Atherosclerosis is caused by the buildup of cholesterol‐rich lipoproteins in blood vessels, causing inflammation, vascular injury, and plaque formation. Plaque rupture or erosion can cause thrombus formation resulting in inadequate blood flow to the heart muscle and MI. Inflammation, particularly driven by macrophages, plays a central role in both atherosclerosis and MI. Recent integrative … Show more

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Cited by 3 publications
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“…In atherosclerosis, macrophages play a pivotal role, undergoing proliferation and apoptosis. Macrophage proliferation contributes to plaque inflammation, while apoptosis, if excessive, may lead to plaque instability ( 45 ). MIF influences macrophage functions, promoting recruitment and inhibiting migration.…”
Section: Discussionmentioning
confidence: 99%
“…In atherosclerosis, macrophages play a pivotal role, undergoing proliferation and apoptosis. Macrophage proliferation contributes to plaque inflammation, while apoptosis, if excessive, may lead to plaque instability ( 45 ). MIF influences macrophage functions, promoting recruitment and inhibiting migration.…”
Section: Discussionmentioning
confidence: 99%