Macrophage-Lymphocyte Interaction and Genetic Control of Immune Responsiveness

Jw, Thomas; Schroer, Joyce A.; Yokomuro, Kozo; Jt, Blake; As, Rosenthal

doi:10.1007/978-1-4684-8914-9_15

Cited by 4 publications

(3 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Monocyte-lymphocyte interaction constitutes the first step in the development of a specific immune response. Such a physical interaction is known to require functionally intact macrophages, while the role of the lymphocyte is considered passive because binding is not decreased by metabolic poisoning of lymphocytes (16,31).…”

Section: Resultsmentioning

confidence: 99%

Correlation between macrophage activation and bactericidal function and Mycobacterium leprae antigen presentation in macrophages of leprosy patients and normal individuals

1989

View full text Add to dashboard Cite

The killing of Mycobacterium leprae by resting and gamma interferon (IFN--y)-activated macrophages in normal subjects and leprosy patients was assessed. Resting macrophages from normal individuals demonstrated the ability to kill M. Ieprae. For macrophages from tuberculoid patients, killing of M. leprae was only achieved in the presence of IFN--y, suggesting that initial T-cell activation occurs prior to the killing of M.

show abstract

Section: Resultsmentioning

confidence: 99%

Correlation between macrophage activation and bactericidal function and Mycobacterium leprae antigen presentation in macrophages of leprosy patients and normal individuals

1989

View full text Add to dashboard Cite

show abstract

“…This underlines a possible interrelationship between receptor expression and immune regulation. We interpret the physical interaction between lymphocytes and antigen-pulsed monocytes to be a reflection of the processing and presentation of the antigen by the monocyte to the lymphocyte and therefore a critical initial step in the perpetuation of a correct immune response [3,22].…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium leprae‐Induced Alterations in Macrophage Fc Receptor Expression and Monocyte‐Lymphocyte Interaction in Familial Contacts of Leprosy Patients

et al. 1985

View full text Add to dashboard Cite

Macrophage Fc receptor expression and monocyte-lymphocyte interaction in the presence of Mycobacterium leprae were examined in familial contacts of leprosy patients. Defective M phi functions similar to those of borderline and lepromatous patients could be observed in approximately 71% of consanguineous contacts and 43% of spouses of index patients. Although the values in the latter group were markedly lower than those of the consanguineous contacts, they tended to be higher than those of normal individuals (20%). These in vitro M phi functions were independent of age, sex, and age at onset of exposure and were only weakly associated with duration of exposure. The outcome of the monocyte-lymphocyte interaction test paralleled to a large extent the in vivo Mitsuda lepromin response. Four contacts with defective M phi functions also showed signs of leprosy. The value of these in vitro tests as markers of 'susceptibility' could therefore prove significant.

show abstract

“…A fundamental component common to these particular immune responses is the formation and surface display of antigen-derived peptide-major histocompatibility complex (MHC) II complexes (Thomas et al, 1979;Gosselin et al, 1993;Luder et al, 1998). Constitutive expression of MHC II is restricted to antigen presenting cells such as dendritic cells, B cells, and macrophages.…”

mentioning

confidence: 99%

Systemic Morphine Administration Suppresses Genes Involved in Antigen Presentation

Beagles¹,

Wellstein²,

Bayer³

2004

Mol Pharmacol

View full text Add to dashboard Cite

Administration of opioids in both humans and animal models results in significant alterations in immune system responsiveness. Although the majority of studies have focused on phenotypic changes in immune cells after short-and long-term morphine administration, few studies have determined whether alterations in gene expression profiles accompany these effects. To address this question, rats were treated with either morphine (20 mg/kg) or saline, and changes in gene expression and function in blood leukocytes were examined. Within 2 h, morphine administration resulted in a decrease in blood leukocyte expression of the major histocompatibility complex class II (MHC II RT1.B ␤) (Ϫ3.27-fold) and related molecules, including the MHC II invariant chain (Ϫ2.73-fold). Furthermore, these changes in gene expression were accompanied by a significant decrease in surface MHC II RT1.B ␤ protein expression, specifically on B lymphocytes. Morphine administration was also found to inhibit IL-4 induced up-regulation of MHC II RT1.B ␤ cell surface expression on B lymphocytes. This is the first demonstration that receptors involved in antigen presentation are modified after systemic morphine administration. We propose that the inability of B lymphocytes to up-regulate key immune proteins, such as the MHC II molecule, after exposure to antigen-induced cytokine production may account for the increase in the susceptibility to bacterial and viral infections such as HIV in both drug abusers and patients receiving morphine.

show abstract

Macrophage-Lymphocyte Interaction and Genetic Control of Immune Responsiveness

Cited by 4 publications

References 41 publications

Correlation between macrophage activation and bactericidal function and Mycobacterium leprae antigen presentation in macrophages of leprosy patients and normal individuals

Correlation between macrophage activation and bactericidal function and Mycobacterium leprae antigen presentation in macrophages of leprosy patients and normal individuals

Mycobacterium leprae‐Induced Alterations in Macrophage Fc Receptor Expression and Monocyte‐Lymphocyte Interaction in Familial Contacts of Leprosy Patients

Systemic Morphine Administration Suppresses Genes Involved in Antigen Presentation

Contact Info

Product

Resources

About