Macrophage Fcγ Receptors Expression Is Altered by Treatment with Dopaminergic Drugs

Gómez, Francisco; Ruiz, Pedro A.; Briceño, F.J.; Rivera, Consuelo; Lopez, R.

doi:10.1006/clim.1998.4665

Cited by 24 publications

(41 citation statements)

References 54 publications

(68 reference statements)

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“…Guinea pigs were injected with equal volumes of a homogeneous suspension of estrogens in steroid suspension vehicle (SSV) (8,15). Sham controls received 1 ml of SSV not containing estrogen.…”

Section: Methodsmentioning

confidence: 99%

“…Chlortianisene (Ct) and promestriene (Pm) were obtained from the pharmacy of our hospital. Doses of estrogens were selected on the basis of those previously used in the treatment of human conditions: 0.005 to 1 mg/kg of body weight for Et, 0.5 to 10 mg/kg for M, 0.5 to 10 mg/kg for Ct, 0.1 to 5 mg/kg for Pm, 2.5 to 10 mg/kg for Ep, and 2.5 to 10 mg/kg for E. Rabbit IgG anti-guinea pig red blood cell (RBC) antibodies were prepared as previously described, purified by Sephacryl S-300 gel filtration and quaternary aminoethyl ion-exchange chromatography (Pharmacia, Piscataway, N.J.), and free of IgM as determined by Ouchterlony analysis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (7,8,15).…”

Section: Methodsmentioning

confidence: 99%

“…Blood was drawn from anesthetized guinea pigs by cardiac puncture. Washed erythrocytes were radiolabeled with [ 51 Cr]sodium chromate (Amersham, Madrid, Spain) and sensitized with an equal volume of IgG antibody, so as to be coated with approximately 3,500 IgG molecules per erythrocyte as described previously (8,15). Treated animals were injected intravenously with 1.7 ϫ 10 8 51 Cr-labeled cells.…”

Section: Methodsmentioning

confidence: 99%

“…Samples of blood were obtained 1 to 120 min after injection, and cell-associated radioactivity was measured in a gamma counter (Gamma 8000; Beckman Instruments, Inc., Fullerton, Calif.). Experiments were also performed with heat-altered erythrocytes to investigate splenic trapping mediated by nonimmune clearance, not only in sham controls but also in animals treated with high-dose estrogen (8,15). Clearance curves were plotted by expressing the number of blood counts per minute at each time point as a percentage of the number of counts per minute at 5 min.…”

Section: Methodsmentioning

confidence: 99%

“…We have studied the effects of the treatment with estrogens approved for clinical use upon splenic-macrophage Fc␥R expression using a well-characterized experimental model, the guinea pig (7,8,15).…”

mentioning

confidence: 99%

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Enhancement of Splenic-Macrophage Fcγ Receptor Expression by Treatment with Estrogens

Gómez

Ruiz

Bernal

et al. 2001

Clin Diagn Lab Immunol

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Enhancement of Splenic-Macrophage Fcγ Receptor Expression by Treatment with Estrogens

Gómez

Ruiz

Bernal

et al. 2001

Clin Diagn Lab Immunol

Self Cite

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Dopamine and Renal Function and Blood Pressure Regulation

Armando

Villar

José

2011

Comprehensive Physiology

105

215

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Dopamine is an important regulator of systemic blood pressure via multiple mechanisms. It affects fluid and electrolyte balance by its actions on renal hemodynamics and epithelial ion and water transport and by regulation of hormones and humoral agents. The kidney synthesizes dopamine from circulating or filtered L-DOPA independently from innervation. The major determinants of the renal tubular synthesis/release of dopamine are probably sodium intake and intracellular sodium. Dopamine exerts its actions via two families of cell surface receptors, D1-like receptors comprising D1R and D5R, and D2-like receptors comprising D2R, D3R, and D4R, and by interactions with other G protein-coupled receptors. D1-like receptors are linked to vasodilation, while the effect of D2-like receptors on the vasculature is variable and probably dependent upon the state of nerve activity. Dopamine secreted into the tubular lumen acts mainly via D1-like receptors in an autocrine/paracrine manner to regulate ion transport in the proximal and distal nephron. These effects are mediated mainly by tubular mechanisms and augmented by hemodynamic mechanisms. The natriuretic effect of D1-like receptors is caused by inhibition of ion transport in the apical and basolateral membranes. D2-like receptors participate in the inhibition of ion transport during conditions of euvolemia and moderate volume expansion. Dopamine also controls ion transport and blood pressure by regulating the production of reactive oxygen species and the inflammatory response. Essential hypertension is associated with abnormalities in dopamine production, receptor number, and/or posttranslational modification.

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Dopaminergic regulation of inflammation and immunity in Parkinson's disease: friend or foe?

Furgiuele,

Pereira,

Martini

et al. 2023

Clin & Trans Imm

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Parkinson's disease (PD) is a neurodegenerative disease affecting 7–10 million people worldwide. Currently, there is no treatment available to prevent or delay PD progression, partially due to the limited understanding of the pathological events which lead to the death of dopaminergic neurons in the substantia nigra in the brain, which is known to be the cause of PD symptoms. The current available treatments aim at compensating dopamine (DA) deficiency in the brain using its precursor levodopa, dopaminergic agonists and some indirect dopaminergic agents. The immune system is emerging as a critical player in PD. Therefore, immune‐based approaches have recently been proposed to be used as potential antiparkinsonian agents. It has been well‐known that dopaminergic pathways play a significant role in regulating immune responses in the brain. Although dopaminergic agents are the primary antiparkinsonian treatments, their immune regulatory effect has yet to be fully understood. The present review summarises the current available evidence of the immune regulatory effects of DA and its mimics and discusses dopaminergic agents as antiparkinsonian drugs. Based on the current understanding of their involvement in the regulation of neuroinflammation in PD, we propose that targeting immune pathways involved in PD pathology could offer a better treatment outcome for PD patients.

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Macrophage Fcγ Receptors Expression Is Altered by Treatment with Dopaminergic Drugs

Cited by 24 publications

References 54 publications

Enhancement of Splenic-Macrophage Fcγ Receptor Expression by Treatment with Estrogens

Enhancement of Splenic-Macrophage Fcγ Receptor Expression by Treatment with Estrogens

Dopamine and Renal Function and Blood Pressure Regulation

Dopaminergic regulation of inflammation and immunity in Parkinson's disease: friend or foe?

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