Macrophage-derived tumor necrosis factor-α mediates diabetic renal injury

Awad, Alaa S.; You, Hanning; Gao, Ting; Cooper, Timothy K.; Nedospasov, Sergei A.; Vacher, Jean; Wilkinson, Patrick; Farrell, Francis X.; Reeves, W. Brian

doi:10.1038/ki.2015.162

Cited by 166 publications

(167 citation statements)

References 72 publications

(88 reference statements)

Supporting

Mentioning

154

Contrasting

Order By: Relevance

“…23 25 26 The inflammatory cytokines TNFα, IL-1β, IL-6 and IL-18 have crucial roles in mediating the glomerular and tubulointerstitial injury induced by diabetes 3940 Here we are showing that in addition to reducing the levels of the components of the Nlrp3 inflammasome, Saxa attenuated the increase in all these four cytokines in T2DM and T1DM models.…”

Section: Discussionmentioning

confidence: 62%

Dipeptidyl peptidase-4 inhibition by Saxagliptin prevents inflammation and renal injury by targeting the Nlrp3/ASC inflammasome

Birnbaum

Bajaj

Qian

et al. 2016

BMJ Open Diab Res Care

View full text Add to dashboard Cite

Background: Glucagon-like peptide-1 (GLP-1) receptor activation delays the progression of diabetic nephropathy (DN) in rodents. The NOD-like receptor 3 (Nlrp3) inflammasome plays an important role in DN. Dipeptidyl peptidase-4 inhibitors (DPP4I) inhibit the degradation of endogenous GLP-1 and various other active substances. We assessed whether DPP4I attenuates diabetes-induced activation of the inflammasome and progression of DN in mice with type 2 diabetes mellitus (T2DM) and type 1 diabetes mellitus (T1DM).Methods: BTBR (T2DM), Akita (T1DM) and their matched non-diabetic control (wild-type (WT)) mice received 8-week treatment with Saxagliptin (Saxa) or vehicle.Results: Kidney weight and kidney/body weight ratio increased in the BTBR and Akita mice compared to their WT mice. Saxa attenuated these changes in the BTBR, but not in the Akita mice and had no effect in the WT mice. Serum blood urea nitrogen and creatinine significantly increased in the BTBR and Akita mice. Saxa attenuated the increase in the BTBR and Akita mice. Saxa improved glycemic control in the BTBR mice, but had no effect on glucose levels in the Akita and WT mice. Serum C reactive protein, tumor necrosis factor α (TNFα), interleukin (IL)-1β, IL-6 and IL-18 were significantly higher in the BTBR and Akita mice than in the WT mice. Saxa attenuated the increase in the BTBR and Akita mice. Kidney and adipose protein levels of apoptosis-associated speck-like protein 1, NLRP3, TNFα and Caspase-1 were higher in the BTBR and Akita mice than in the WT mice. Saxa reduced the levels in both types of diabetic mice.

show abstract

Section: Discussionmentioning

confidence: 62%

Dipeptidyl peptidase-4 inhibition by Saxagliptin prevents inflammation and renal injury by targeting the Nlrp3/ASC inflammasome

Birnbaum

Bajaj

Qian

et al. 2016

BMJ Open Diab Res Care

View full text Add to dashboard Cite

show abstract

“…This increased local production of TNF-a could result in urinary release, which confirms our data. The importance of this cytokine in the progression of DN was also demonstrated experimentally by Awad et al [26], who showed that TNF-a-neutralizing antibody prevents kidney hypertrophy, albuminuria and preserves kidney function in a murine model of DM1. Furthermore, we observed a correlation between TNF-a and the markers currently used in the DN evaluation, suggesting that the use of all these markers together could enhance the sensibility of laboratorial diagnosis of DN progression.…”

Section: Discussionmentioning

confidence: 69%

Cytokines profile and its correlation with endothelial damage and oxidative stress in patients with type 1 diabetes mellitus and nephropathy

et al. 2016

View full text Add to dashboard Cite

The aim of the present study was to investigate the association between the presence of albuminuria and cytokines profile with biomarkers of endothelial damage and oxidative stress in patients with type 1 diabetes mellitus (DM1). The sample was composed by 35 healthy individuals, 63 DM1 patients with normoalbuminuria (<30 mg of albumin/g of creatinine) and 62 DM1 patients with micro- and macroalbuminuria (≥30 mg of albumin/g of creatinine). Plasma and urinary cytokines (TNF-α, IL-6 and IL-10) and thrombomodulin levels were determined by ELISA. Oxidative status was evaluated using the TBARS and MTT assays. Diabetic patients were characterized by elevated levels of urinary cytokines TNF-α, IL-6 and IL-10. Those with macroalbuminuria presented significantly higher TNF-α and IL-10 urinary levels when compared to other groups. Urinary and plasmatic levels of TNF-α were positively correlated with plasma levels of cystatin C, creatinine, urea and albuminuria, while they were negatively correlated with estimated glomerular filtration rate. Urinary IL-10 levels proved positive correlation with fasting glucose, HbA1c, thrombomodulin and TBARS, while IL-6 plasma levels were positively correlated with HbA1c and albuminuria. Only urinary TNF-α levels were associated with the presence and severity of macroalbuminuria, after logistic regression analysis. This finding suggests that measurement of urinary TNF-α level may be helpful to evaluate progression to nephropathy in DM1 patients.

show abstract

“…Oxidative stress plays a major role in the pathogenesis of T1DM and reactive oxygen species (ROS) which could play a pivotal role in the development and progression of DM [9]. Many natural products have been shown to decrease oxidative stress in diabetic animals.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective and Antioxidant Activities of the Essential Oil from Maqian (Zanthoxylum myriacanthum var. pubescens) in Streptozotocin-induced Diabetic Mice

Dahab¹,

Xu²,

Zhang³

2018

dtbh

View full text Add to dashboard Cite

Abstract. Background & objectives: Diabetes is a metabolic disorder and it can affect many organs and different types of antioxidant enzymes through increased production of reactive oxygen species (ROS). A few essential oils have been reported to have antioxidant and antidiabetic effects. The objective of our present study is to explore the anti-diabetic potential of Maqian essential oil (MQEO). Aim: The aim of this study was to evaluate the hepatoprotective and antioxidant effect of MQEO in streptozotocin (STZ)-induced diabetes in mice. Method: Diabetes was induced in male ICR mice with a single intraperitoneal injection of STZ (200 mg/kg body weight). MQEO was administered orally for 7 days. At the end of experiment liver was weighed and enzymatic and non-enzymatic oxidative stress parameters were measured, and part of liver was examined by hematoxylin/eosin staining. Results: MQEO treatment resulted in significantly decreased MDA level and increased antioxidant enzymes including superoxide dismutase, catalase, glutathione peroxidase and glutathione-Stransferase in STZ-diabetic mice. Histology examination showed severe pathology changes in diabetic mice including congestion of sinusoids and focal necrosis in liver and MQEO restored tissue architecture almost as in the normal control mice. Conclusion: MQEO has pronounced antioxidant effect and could reverse liver damages in STZ-induced diabetic mice. It could be useful for controlling diabetic complications.

show abstract

Macrophage-derived tumor necrosis factor-α mediates diabetic renal injury

Cited by 166 publications

References 72 publications

Dipeptidyl peptidase-4 inhibition by Saxagliptin prevents inflammation and renal injury by targeting the Nlrp3/ASC inflammasome

Dipeptidyl peptidase-4 inhibition by Saxagliptin prevents inflammation and renal injury by targeting the Nlrp3/ASC inflammasome

Cytokines profile and its correlation with endothelial damage and oxidative stress in patients with type 1 diabetes mellitus and nephropathy

Hepatoprotective and Antioxidant Activities of the Essential Oil from Maqian (Zanthoxylum myriacanthum var. pubescens) in Streptozotocin-induced Diabetic Mice

Contact Info

Product

Resources

About