Macrophage-Derived Exosomes as Advanced Therapeutics for Inflammation: Current Progress and Future Perspectives

Song, Yanjuan; Hu, Jing; Ma, Chunlian; Liu, Hua; Li, Zhanghua; Yang, Yi

doi:10.2147/ijn.s449388

Cited by 5 publications

(1 citation statement)

References 140 publications

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“…This mechanism by which immune cells can signal to the placental unit may aid responses to maternal inflammation and infection and thereby, serve to limit harm to the fetus. Indeed, researchers have highlighted that potential role of macrophage-derived exosomes as therapeutics for clinical translation ( 71 ). However, further work is needed to study their benefit at the maternal-fetal interface and in improving pregnancy outcomes.…”

Section: Receptor-mediated Endocytosis At the Maternal-fetal Interfacementioning

confidence: 99%

Endocytosis at the maternal-fetal interface: balancing nutrient transport and pathogen defense

Fan,

Wu,

Sferruzzi-Perri

et al. 2024

Front. Immunol.

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Endocytosis represents a category of regulated active transport mechanisms. These encompass clathrin-dependent and -independent mechanisms, as well as fluid phase micropinocytosis and macropinocytosis, each demonstrating varying degrees of specificity and capacity. Collectively, these mechanisms facilitate the internalization of cargo into cellular vesicles. Pregnancy is one such physiological state during which endocytosis may play critical roles. A successful pregnancy necessitates ongoing communication between maternal and fetal cells at the maternal-fetal interface to ensure immunologic tolerance for the semi-allogenic fetus whilst providing adequate protection against infection from pathogens, such as viruses and bacteria. It also requires transport of nutrients across the maternal-fetal interface, but restriction of potentially harmful chemicals and drugs to allow fetal development. In this context, trogocytosis, a specific form of endocytosis, plays a crucial role in immunological tolerance and infection prevention. Endocytosis is also thought to play a significant role in nutrient and toxin handling at the maternal-fetal interface, though its mechanisms remain less understood. A comprehensive understanding of endocytosis and its mechanisms not only enhances our knowledge of maternal-fetal interactions but is also essential for identifying the pathogenesis of pregnancy pathologies and providing new avenues for therapeutic intervention.

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Section: Receptor-mediated Endocytosis At the Maternal-fetal Interfacementioning

confidence: 99%

Endocytosis at the maternal-fetal interface: balancing nutrient transport and pathogen defense

Fan,

Wu,

Sferruzzi-Perri

et al. 2024

Front. Immunol.

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Novel insights into the pathological features of COPD: Focus on oxidative stress and mitophagy

Gao,

Shen,

Chen

2024

Clinical and Translational Dis

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Chronic airway obstructive pulmonary disease (COPD) is a preventable and curable disease characterised by persistent airflow limitation. It is characterised by chronic bronchitis and/or emphysema, and its aetiology is related to various factors such as smoking and infectious factors, and so forth. The pathogenesis is complex and prone to frequent exacerbations, and the prognosis of acute exacerbations of COPD is often poor. As a crucial component of the innate immune system, lung macrophages significantly influence the onset and progression of COPD. When macrophage mitochondria become dysfunctional, many macrophage functions (e.g., phagocytosis, cytokine secretion, chemotaxis, etc.) change. The aim of this paper is to describe the three major pathological features of COPD (oxidative stress imbalance, macrophage polarisation and mitochondrial membrane potential [MMP] production and mitochondrial autophagy), to describe in detail the mechanism of mitochondrial autophagy pathway and its association with oxidative stress and macrophage polarisation and to emphasise the role of macrophage mitochondrial reactive oxygen species (mROS) in COPD, with the aim of providing ideas and directions for subsequent studies.

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Mesenchymal stem cell-based therapy for paraquat-induced lung injury

Zhang,

Li,

2024

Cell Biol Toxicol

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Paraquat poisoning results in significant pulmonary damage, but current treatments are only minimally effective in repairing the injured lung tissues. Recent research has highlighted the promise of using stem cell therapy, namely mesenchymal stem cells, as a new method for treating paraquat toxicity. These cells have shown effectiveness in decreasing inflammation, apoptosis, and fibrosis in the mice lungs subjected to paraquat. The therapeutic implications of mesenchymal stem cells are believed to arise from their release of bioactive proteins and their capacity to regulate inflammatory responses. However, additional clinical study is required to validate these therapies' efficacy. This review thoroughly explores the pathophysiology of paraquat poisoning and the properties of mesenchymal stem cells. Additionally, it critically assesses the long-term safety and effectiveness of mesenchymal stem cell therapies, which is crucial for developing more dependable and effective treatment protocols. In summary, although mesenchymal stem cells offer promising prospects for treating lung injuries, more investigations are required to optimize their therapeutic promise and ensure their safe clinical application in the context of paraquat poisoning. Supplementary Information The online version contains supplementary material available at 10.1007/s10565-024-09911-3.

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Macrophage-Derived Exosomes as Advanced Therapeutics for Inflammation: Current Progress and Future Perspectives

Cited by 5 publications

References 140 publications

Endocytosis at the maternal-fetal interface: balancing nutrient transport and pathogen defense

Endocytosis at the maternal-fetal interface: balancing nutrient transport and pathogen defense

Novel insights into the pathological features of COPD: Focus on oxidative stress and mitophagy

Mesenchymal stem cell-based therapy for paraquat-induced lung injury

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