Macrophage-derived CCL24 promotes fibrosis and worsens cardiac dysfunction during heart failure
Preethy Parthiban,
Fanta Barrow,
Huy Nguyen
et al.
Abstract:Inflammation is a significant risk factor and contributes to cardiovascular disease by driving both adaptive and maladaptive processes. Macrophages are the most abundant immune cells in the heart and play an important role in the remodeling of cardiac tissue. We have previously shown an overall protective function of resident cardiac macrophages after pressure-overloaded injury. However, a subpopulation of resident macrophages also expresses high levels of the profibrotic CC motif chemokine ligand 24 (CCL24), … Show more
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