Macrophage activation syndrome in two infants with multisystem inflammatory syndrome in children

García-Domínguez, Miguel; Torres, Cynthia; Carreón-Guerrero, Juan Manuel; Quibrera, José; Arce-Cabrera, Daniela; Yamazaki‐Nakashimada, Marco Antonio

doi:10.1002/pbc.29199

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…Given the life-threatening clinical course of MAS, early diagnosis in KD-like hyperinflammatory diseases, including MIS-C and KDSS, is essential [ 33 ]. When patients with MIS-C or KDSS show unexpected clinical deterioration despite appropriate treatment, screening tests, including those that measure ferritin level, should be performed to rule out MAS [ 34 , 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Similarities and Differences between Multisystem Inflammatory Syndrome in Children (MIS-C) and Kawasaki Disease Shock Syndrome

Lee,

Kim,

Cho

et al. 2023

Children

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This study aimed to investigate the characteristics of COVID-19-associated multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease shock syndrome (KDSS) and to compare the similarities and differences between the two diseases. The incidence of KDSS and MIS-C was also estimated. Medical records of patients diagnosed with MIS-C or KDSS at four hospitals from January 2013 to December 2022 were retrospectively reviewed. Thirty-one patients were enrolled in the study in either an MIS-C group (n = 22) or a KDSS group (n = 9). The incidence of KDSS in KD was 0.8% (9/1095) and the incidence of MIS-C versus KD was 10.2% (22/216). Compared with the MIS-C group, the KDSS group had longer hospital stays and more severe systemic inflammation (e.g., anemia, elevated C-reactive protein, hypoalbuminemia, and pyuria) and organ dysfunction (e.g., number of involved organs, shock, vasoactive infusion, and intensive care unit admission). All patients in the MIS-C group, but none in the KDSS group, including two patients during the COVID-19 pandemic, had laboratory evidence of SARS-CoV-2 infection. MIS-C and KDSS shared demographic, clinical, and laboratory characteristics; organ dysfunction; treatment; and outcomes. Overall severity was more severe in patients with KDSS than in those with MIS-C. The most important difference between MIS-C and KDSS was whether SARS-CoV-2 was identified as an infectious trigger.

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Section: Discussionmentioning

confidence: 99%

Similarities and Differences between Multisystem Inflammatory Syndrome in Children (MIS-C) and Kawasaki Disease Shock Syndrome

Lee,

Kim,

Cho

et al. 2023

Children

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show abstract

“…Severe cases may cause obstruction or even perforation, which should require prompt surgical intervention. Intestinal perforation in KD, as in case 2, is rare, and only two cases have been reported to date (18,19).…”

Section: Discussionmentioning

confidence: 99%

Kawasaki disease complicated with shock syndrome, macrophage activation syndrome, and acute abdomen in children: Two case reports

She

Chen

2023

Front. Pediatr.

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BackgroundKawasaki disease (KD) is an acute systemic vasculitis that can involve multiple organs. Few reports have been published about KD patients presenting with multiple complications such as acute abdomen, KD shock syndrome (KDSS), and macrophage activation syndrome (MAS).Case DescriptionWe present the cases of two males (9 and 12 years old) diagnosed with KD accompanied by rare manifestations. Case 1 is a 9-year-old male treated for acute appendicitis, KDSS, and MAS. Case 2 is a 12-year-old male who presented with KDSS, MAS, and an ileal perforation. They were treated with intravenous immunoglobulin, aspirin, high-dose corticosteroids, vasoactive drugs, and symptomatic treatment, with good outcomes.ConclusionsClinicians should be aware of the possibility of KD in the presence of fever and unusual manifestations, such as severe inflammatory indicators and acute abdomen that is nonresponsive to antibiotic therapy. Meanwhile, KD-related unusual complications should be recognized, such as KDSS and MAS.

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“…To the Editor, We read the article "Macrophage activation syndrome (MAS) in two infants with the multisystem inflammatory syndrome in children" concerning SARS-CoV-2 with interest. 1 In our case, a 3-year-6-month-old female was admitted to our hospital after experiencing 2 months of continuous fever, night sweats, and weight loss. Throughout her medical history, she was given a variety of broad-spectrum antibiotics in another hospital.…”

Section: Comment On: Macrophage Activation Syndrome In Two Infants Wi...mentioning

confidence: 90%

Comment on: Macrophage activation syndrome in two infants with the multisystem inflammatory syndrome in children: Mott cells, erythrophagocytosis, and dyserythropoiesis after COVID‐19 infection

Karamercan

Kaya

2023

Pediatric Blood & Cancer

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Macrophage activation syndrome in two infants with multisystem inflammatory syndrome in children

Cited by 5 publications

References 7 publications

Similarities and Differences between Multisystem Inflammatory Syndrome in Children (MIS-C) and Kawasaki Disease Shock Syndrome

Similarities and Differences between Multisystem Inflammatory Syndrome in Children (MIS-C) and Kawasaki Disease Shock Syndrome

Kawasaki disease complicated with shock syndrome, macrophage activation syndrome, and acute abdomen in children: Two case reports

Comment on: Macrophage activation syndrome in two infants with the multisystem inflammatory syndrome in children: Mott cells, erythrophagocytosis, and dyserythropoiesis after COVID‐19 infection

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