Macrophage activation by polysaccharide biological response modifier isolated from Aloe vera L. var. chinensis (Haw.) Berg.

Liu, C.; Leung, M.Y.K.; Koon, J.C.M.; Zhu, Limeng; Ye, Hui; Yu, Biao; Fung, Kwok‐Pui

doi:10.1016/j.intimp.2006.04.013

Cited by 71 publications

(34 citation statements)

References 46 publications

(47 reference statements)

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“…In the present study, we demonstrated that intraperitoneal injection of water-soluble CPE promoted migration of macrophages into the peritoneal cavity. Considering that migration of macrophages into the peritoneal cavity serves as an index of macrophage activation [29,30], our results are in accordance with the results of previous work, and provide further evidence for the proinflammatory action of watersoluble CPE. It should be noted, however, that there are also some reports of anti-inflammatory action of the watersoluble fraction of C. procera latex [2,4,31].…”

Section: Discussionsupporting

confidence: 92%

Extract from Calotropis procera latex activates murine macrophages

et al. 2009

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Calotropis procera latex has long been used in traditional medicines. Extracts from C. procera latex have been reported to have various pharmacological actions, including protection from myocardial infarction, hepatoprotective action, antitumor activity, antinociceptive, and pro- and anti-inflammatory actions. To evaluate the immunomodulatory functions of the water-soluble C. procera extract (CPE), we investigated its ability to activate macrophages-effector cells in inflammatory and immune responses. Intraperitoneal injection of CPE in mice (2 mg/mouse) induced migration of macrophages to the intraperitoneal cavity, confirming the proinflammatory effects of water-soluble CPE. The direct effects of CPE on macrophages were then assessed by measuring the production of nitric oxide (NO) as an indicator for macrophage activation. Addition of CPE (1-10 microg/ml) to the culture medium of the murine monocyte/macrophage cell line RAW264.7 caused an increase in NO production in a time- and dose-dependent manner. CPE-elicited NO production was blocked by application of an inhibitor of inducible nitric oxide synthase (iNOS). Expression of iNOS mRNA was induced by treatment of cultured macrophages with CPE. Injection of CPE in mice also resulted in an increase in plasma NO level. The results suggest that CPE activates macrophages and facilitates NO production via up-regulation of iNOS gene expression.

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Section: Discussionsupporting

confidence: 92%

Extract from Calotropis procera latex activates murine macrophages

et al. 2009

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“…4-d). Several in vitro studies have demonstrated that Aloe vera components like mannose stimulate macrophages through binding to mannose receptor on the surface [12,19,22,23,32]. Polysaccharides, mannose and acemannan are identified constituents of carbohydrates present in Aloe vera gel [4, Fig.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Aloe Vera Oral Administration on Cutaneous Wound Healing in Type 2 Diabetic Rats

Atiba

Ueno

Uzuka

2011

The Journal of Veterinary Medical Science

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ABSTRACT. Delayed wound healing is one of the complications of diabetes mellitus. The present study was performed to investigate the effect of Aloe vera oral administration on open wounds in type 2 diabetic rats. Full thickness open wounds (1.5  1.5 cm) were created under general anesthesia on the backs of the rats. These rats were divided into two group, a control group (Group C) and an Aloe vera oral administration group (Group A). Each wound area was measured on days 1, 2, 4 and 8 postwounding. The stages of wound granulation tissues were evaluated histopathologically. The expression of transforming growth factor (TGF)-1 and vascular endothelial growth factor (VEGF) were determined by immunohistochemically. The wounds were significantly contracted in Group A on days 2, 4 and 8 postwounding. Histological results revealed that the inflammatory cell infiltration, angiogenesis, extracellular matrix deposition and epithelialization were promoted in Group A, respectively. The immunohistochemical results revealed that both TGF-1 and VEGF protein-positive cells increased in Group A on day 4 postwounding. We concluded that Aloe vera oral administration accelerated wound healing in type 2 diabetic rats.

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“…Aloe leaves contain many physiologically active substances with immunomodulatory, antimicrobial, anti-inflammatory and wound-healing properties, belonging to glycoproteins, anthraquinones, polysaccharides and low-molecular-weight species [1]. Some of these compounds also presented indirect and direct anti-tumor activity [2][3][4][5][6][7]. It was reported in experiments on mice implanted with sarcoma cells that Aloe polysaccharides between 400 and 5 KDa molecular size exhibited the most potent antitumor activity in vivo and in vitro [8].…”

Section: Introductionmentioning

confidence: 99%