Macrophage activation and nitric oxide production by water soluble components of Hericium erinaceum

Son, Chang Gue; Shin, Jang Woo; Cho, Jung Hyo; Cho, Chong Kwan; Yun, Cheol‐Heui; Chung, Wan-Tae; Han, Seung Hyun

doi:10.1016/j.intimp.2006.03.005

Cited by 49 publications

(31 citation statements)

References 36 publications

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“…For instance, polysaccharides extracted from mushrooms such as L. edodes (Lee et al, 2008), T. matsutake (Byeon et al, 2009), H. erinaceus (Son et al, 2006) and I. obliquus (Kim et al, 2006) are well-known to possess important immunostimulating properties. However, the signaling pathway toward the activation of immunocytes such as macrophages and T cells by polysaccharides isolated from I. obliquus is still unclear.…”

Section: Discussionmentioning

confidence: 99%

Immunostimulating Activity by Polysaccharides Isolated from Fruiting Body of Inonotus obliquus

Won

Lee

Kwon

et al. 2011

Molecules and Cells

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In this study, we investigated the immunostimulating activity of polysaccharides isolated from fruiting body of Inonotus obliquus (PFIO). Additionally, the signaling pathway of PFIO-mediated macrophage activation was investigated in RAW264.7 macrophage cells. We found that PFIO was capable of promoting NO/ROS production, TNF-α secretion and phagocytic uptake in macrophages, as well as cell proliferation, comitogenic effect and IFN-γ/IL-4 secretion in mouse splenocytes. PFIO was able to induce the phosphorylation of three MAPKs as well as the nuclear translocation of NF-κB, resulting in activation of RAW264.7 macrophages. PFIO also induced the inhibition of TNF-α secretion by anti-TLR2 mAb, consequently, PFIO might be involved in TNF-α secretion via the TLR2 receptor. In addition, our results showed that oral administration of PFIO suppressed in vivo growth of melanoma tumor in tumorbearing mice. In conclusion, our experiments presented that PFIO effectively promotes macrophage activation through the MAPK and NF-κB signaling pathways, suggesting that PFIO may potentially regulate the immune response.

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Section: Discussionmentioning

confidence: 99%

Immunostimulating Activity by Polysaccharides Isolated from Fruiting Body of Inonotus obliquus

Won

Lee

Kwon

et al. 2011

Molecules and Cells

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“…Immuno-regulatory functions of H. erinaceus have been demonstrated in an aqueous extract by a stimulation of inducible nitric oxide gene expression followed by nitric oxide production in macrophages via enhancement of activation of the transcription factor, NF-kappaB (Son et al 2006). Exo-polymers produced in submerged mycelia culture show a potent hypolipidemic effect (Yang et al 2003, Yang et al 2002.…”

Section: Hericiaceaementioning

confidence: 99%

Healing mushrooms of Uttarakhand Himalaya, India

Bhatt¹

2018

CREAM

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The Himalayan forests of Uttarakhand represent a natural repository for the rich biodiversity of the Indian subcontinent. Forest resources in this region form an integral part of socio-economy and cultural practices. Mushrooms are forest products which have been used as food for a long time but very few for therapeutic purposes, which is associated to the lack of awareness and knowledge. If properly identified, these mystic organisms can be very promising in prevention and cure of various ailments. The present study is a part of macrofungal exploration carried out from 2015-2016. As a result, 15 mushroom species are identified which possess a spectrum of bioactive compounds and therapeutic potential. All of these species are morphologically described along with the habit, habitat and notes on their healing capacities.

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“…processes such as regulation of blood pressure, neurotransmission, signal transduction, antimicrobial defense, cellular redox regulation, apoptosis [22], and immunomodulation [23]. Tomimori et al [24], reported that Crassocephalum crepidioides extract suppressed tumor growth through NO production through nuclear factor-κB signaling pathway.…”

Section: Dhanasezhian Et Almentioning

confidence: 99%

Nitric Oxide Production and Antioxidant Activity of Dried Fruit Extracts of Terminalia Chebula

Dhanasezhian

Srivani

Rameshkumar

2018

Asian J Pharm Clin Res

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Objective: The dried ripe fruits of Terminalia chebula have traditionally been used to treat various ailments as it has a wide spectrum of pharmacological activities. Hence, in the present study, we aimed to explore the antioxidant activity, nitric oxide production, cytotoxicity, and phytocompounds present in the aqueous and methanol extract of T. chebula. Methods:The dry fruits of T. chebula were extracted using water and methanol, and the extracts were concentrated by lyophilization method. Phytochemical analysis was done by gas chromatography and mass spectrometry and Fourier-transform infrared spectroscopy. The free radical scavenging activity of T. chebula was estimated by 1,1diphenyl 2, picrylhydrazyl method. RAW 264.7 cells were stimulated with aqueous and methanol extracts, and the production of nitric oxide was estimated by spectrophotometric method using Griess reagent. Cytotoxicity assay was performed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method and percentage of cell viability was calculated.Results: Aqueous and methanolic extracts of the dry fruit of T. chebula showed non-toxic to RAW 264.7 cells at the concentration of 2 mg and 1.5 mg, respectively. These concentrations showed high free radical scavenging activity and production of optimum concentration of nitric oxide in RAW 264.7 cells. Conclusion:Fruit extracts of T. chebula possess properties of nitric oxide production and high free radical scavenging activity; these properties could be useful in the development of immunomodulatory drugs as well as protection against various human diseases associated with oxidative stress.

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Macrophage activation and nitric oxide production by water soluble components of Hericium erinaceum

Cited by 49 publications

References 36 publications

Immunostimulating Activity by Polysaccharides Isolated from Fruiting Body of Inonotus obliquus

Immunostimulating Activity by Polysaccharides Isolated from Fruiting Body of Inonotus obliquus

Healing mushrooms of Uttarakhand Himalaya, India

Nitric Oxide Production and Antioxidant Activity of Dried Fruit Extracts of Terminalia Chebula

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