Macrophage accumulation within coronary arterial wall in diabetic patients with acute coronary syndrome: a study with in-vivo intravascular imaging modalities

Kogo, Takaaki; Hiro, Takafumi; Kitano, Daisuke; Takayama, Tadateru; Fukamachi, Daisuke; Morikawa, Tomoyuki; Sudo, Mitsumasa; Okumura, Yasuo

doi:10.1186/s12933-020-01110-8

Cited by 10 publications

(7 citation statements)

References 55 publications

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“…Macrophages. Macrophages also sense cyclic pressure through Piezo1 resulting in expression of several inflammatory mediators including of IL-1β [75,131], IL-6, IL-8 as well as TNF-α [132] (Figures 3 & 4), which instigate inflammation as well as matrix metalloproteinases that stimulate cell proliferation [133] and induce plaque weakening [134][135][136][137]. Additionally, macrophage activities can be control by Piezo1 through various mechanical cues, as it is highly expressed and functions in macrophage [75], considering matrix stiffness and topology were among mechanical factors that control the differentiating, functioning and proliferating of macrophages [132].…”

Section: Proliferationmentioning

confidence: 99%

Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target

Shinge¹,

Zhang²,

Din³

et al. 2022

Int. J. Biol. Sci.

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Purpose of Review: Atherosclerosis is the principal cause of cardiovascular diseases (CVDs) which are the major cause of death worldwide. Mechanical force plays an essential role in cardiovascular health and disease. To bring the awareness of mechanosensitive Piezo1 role in atherosclerosis and its therapeutic potentials we review recent literature to highlight its involvement in various mechanisms of the disease. Recent Findings: Recent studies reported Piezo1 channel as a sensor, and transducer of various mechanical forces into biochemical signals, which affect various cellular activities such as proliferation, migration, apoptosis and vascular remodeling including immune/inflammatory mechanisms fundamental phenomenon in atherogenesis. Summary: Numerous evidences suggest Piezo1 as a player in different mechanisms of cell biology, including immune/inflammatory and other cellular mechanisms correlated with atherosclerosis. This review discusses mechanistic insight about this matter and highlights the drugability and therapeutic potentials consistent with emerging functions Piezo1 in various mechanisms of atherosclerosis. Based on the recent works, we suggest Piezo1 as potential therapeutic target and a valid candidate for future research. Therefore, a deeper exploration of Piezo1 biology and translation towards the clinic will be a novel strategy for treating atherosclerosis and other CVDs.

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Section: Proliferationmentioning

confidence: 99%

Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target

Shinge¹,

Zhang²,

Din³

et al. 2022

Int. J. Biol. Sci.

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“…Furthermore, macrophage accumulation was more common in patients with longer DM duration, which has been reported to play an important role during various steps of atherosclerosis and promote ACS events, thus indicating a higher level of plaque vulnerability. 33 HbA1c is not only a useful biomarker of long-term glycemic control but also a good predictor of atherosclerosis. For example, Shah et al 34 reported that a 1% increase in HbA1c is associated with an approximately 30% increase in probability of a thicker carotid IMT.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Impact of prediabetes and duration of diabetes on radial artery atherosclerosis in acute coronary syndrome patients: An optical coherence tomography study

Tang

Wang

et al. 2022

Diabetes and Vascular Disease Research

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Background Prediabetes (PDM) and diabetes mellitus (DM) are common among acute coronary syndrome (ACS) patients. The present study evaluated the association between diabetes status and radial artery (RA) atherosclerosis using optical coherence tomography (OCT) in ACS patients. Methods A total of 335 ACS patients who underwent RA OCT were categorized into the DM group, the PDM group, and the normal glucose metabolism (NGM) group. OCT characteristics and clinical variables were compared. Results RA atherosclerotic plaques were more frequent in the PDM and DM groups than in the NGM group (38.7% vs. 33.3% vs. 16.1%, p = 0.001). Lipid and calcified plaque occurrence were significantly more common in the DM group, followed by the PDM and NGM groups (19.3% vs. 14.6% vs. 6.5%, p = 0.027; 11.8% vs. 6.5% vs. 1.1%, p = 0.009). The prevalence of microvessels in the PDM group was significantly higher (42.7% vs 23.7%, p = 0.017) than in the NGM group but was comparable to the DM group. Multivariate analysis revealed that HbA1c level and age were independent predictors of RA plaque formation and eccentric intimal hyperplasia (all p<0.05). Conclusions RA atherosclerosis characteristics differ according to diabetes status. HbA1c level could be a useful marker for RA atherosclerosis progression in ACS patients.

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“…Cholesterol crystals, a hallmark of advanced atherosclerotic lesions, were found to be associated with characteristics of vulnerable plaques in ACS culprit lesions [ 24 , 25 ]. Abundant and homogeneous macrophage accumulation in coronary arterial wall was also found in ACS patients with DM [ 26 ]. Another study investigated non-culprit plaque in STEMI patients, and found that STEMI patients with culprit plaque erosion have a limited pancoronary vulnerability than STEMI patients with plaque rupture, which may also explain the better outcomes in patients with erosion than rupture [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Association between apolipoprotein B/A1 ratio and coronary plaque vulnerability in patients with atherosclerotic cardiovascular disease: an intravascular optical coherence tomography study

Deng

Lei

et al. 2021

Cardiovasc Diabetol

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Background Apolipoprotein (Apo) A1 and Apo B are strongly associated with the risk of atherosclerotic cardiovascular disease (ASCVD). However, the relationship between the Apo B/A1 ratio and the morphology of coronary vulnerable plaques has not been fully elucidated in patients with ASCVD. Methods A total of 320 patients with ASCVD undergoing percutaneous coronary intervention were enrolled and assigned into acute coronary syndrome (ACS) or chronic coronary syndrome (CCS) group. The morphology of culprit plaque was analyzed by intravascular optical coherence tomography. Association between the Apo B/A1 ratio and coronary vulnerable plaques were evaluated using logistic regression models and receiver operator characteristic (ROC) curve analyses. Results The Apo B/A1 ratio was higher in ACS patients than CCS patients (0.77 ± 0.28 vs. 0.64 ± 0.22, P < 0.001) and it was also higher in patients with plaque rupture, erosion or thrombus than those without culprit plaques. The high Apo B/A1 ratio was associated with high percent of vulnerable plaques compared with low ratio group. The Apo B/A1 ratio was negatively related to fibrous cap thickness in lipid-rich plaque (r = − 0.228, P = 0.043). Univariate and multivariate logistic regression analyses revealed that the Apo B/A1 ratio was an independent factor of plaque rupture, erosion, and thrombus. The area under the ROC curve of the Apo B/A1 ratio for plaque rupture, erosion, and thrombus were 0.632, 0.624, and 0.670 respectively (P < 0.001 for all), which were higher than that of low-density lipoprotein cholesterol. Conclusions The Apo B/A1 ratio is an independent predictor for plaque rupture, erosion, and thrombus in patients with ASCVD.

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Macrophage accumulation within coronary arterial wall in diabetic patients with acute coronary syndrome: a study with in-vivo intravascular imaging modalities

Cited by 10 publications

References 55 publications

Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target

Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target

Impact of prediabetes and duration of diabetes on radial artery atherosclerosis in acute coronary syndrome patients: An optical coherence tomography study

Association between apolipoprotein B/A1 ratio and coronary plaque vulnerability in patients with atherosclerotic cardiovascular disease: an intravascular optical coherence tomography study

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