Macronutrient Intake as a Mediator with FTO to Increase Body Mass Index

Hardy, Dale S.; Racette, Susan B.; Hoelscher, Deanna M.

doi:10.1080/07315724.2013.879458

Cited by 12 publications

(9 citation statements)

References 27 publications

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“…A similar study in an adult population, most of whom had obesity , also reported no difference in dietary macronutrient composition consumed despite a 350‐kcal difference in overall intake predicted by the AA genotype compared with the AT/TT genotype. Other recent studies of self‐reported dietary intake in adults have suggested a small but significant impact of the risk allele on protein intake . However, in contrast to the majority of laboratory studies, these studies reported that each risk allele predicted lower caloric intake, which the authors hypothesize resulted from individuals with higher BMI (who may also be more likely to carry the risk allele) under‐ or misreporting intake.…”

Section: Discussionmentioning

confidence: 77%

The FTO Gene and Measured Food Intake in 5‐ to 10‐Year‐Old Children Without Obesity

Ranzenhofer

Mayer

Davis

et al. 2019

Obesity

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Objective: Genetic variation in the first intron of FTO (e.g., single-nucleotide polymorphism [SNP] rs9939609) is strongly associated with adiposity. This effect is thought to be mediated (at least in part) via increasing caloric intake, although the precise molecular genetic mechanisms are not fully understood. Prior pediatric studies of FTO have included youth with overweight and obesity; however, they have not informed whether a genotypic effect on ingestive behavior is present prior to obesity onset. Therefore, this study investigated the association between FTO and caloric intake in children aged 5 to 10 years without obesity (adiposity ≤ 95th percentile). Methods: A total of 122 children were genotyped for rs9939609 and ate ad libitum from a laboratory lunch buffet following a standardized breakfast. Linear regressions, adjusting for body mass, were used to examine the association between FTO "dose" (number of copies of SNP rs9939609) and intake variables. Results: There was a significant association between FTO and total intake. Each risk allele predicted an additional 64 calories, accounting for 3% of the variance. There were no associations between FTO and macronutrient preference, energy density, or diet variety. Results were influenced by race. Conclusions: Results corroborate and extend prior work by showing a dose-dependent effect on food intake in children without obesity.

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Section: Discussionmentioning

confidence: 77%

The FTO Gene and Measured Food Intake in 5‐ to 10‐Year‐Old Children Without Obesity

Ranzenhofer

Mayer

Davis

et al. 2019

Obesity

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“…Likewise, it has also been suggested that the influence of the FTOrs9939609 on adiposity may be greater in an "obesogenic" environment, such as high fat diets [13], or low levels of physical activity [3,14]. Studies in adults reported that dietary macronutrient distribution modified the influence of the FTOrs9939609 on adiposity [13,15] and insulin sensitivity [16], though contradictory findings have also been reported [17]. Given that dietary fat content has been previously associated with increased adiposity in adolescents [18,19], and that low energy and low fat diets have been proposed as effective strategies to avoid excess adiposity in youth carrying the A risk allele [20], the aims of the present study were (i) to examine the association between the FTOrs9939609 genotypes and dietary energy and macronutrient intake , and (ii) to explore whether dietary fat intake modifies the association of the FTOrs9939609 with adiposity in European adolescents participating in the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross sectional study.…”

Section: Introductionmentioning

confidence: 99%

Dietary fat intake modifies the influence of the FTO rs9939609 polymorphism on adiposity in adolescents: The HELENA cross-sectional study

Labayen

Ruiz

Huybrechts

et al. 2016

Nutrition, Metabolism and Cardiovascular Diseases

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“…FTO gene variants played important roles in appetite regulation, food intake, tendency to choose energydense food (high fat and high carbohydrate diet) (30). The carriers of A allele FTO rs9939609 had Energy-dense food choices, higher body weight, and overeating behaviors (31).…”

Section: Discussionmentioning

confidence: 99%

The association between FTO genotype and macro-nutrients’ intake in overweight adults

Mehrdad

Doaei

Eftekhari

2019

Preprint

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Background Macro-nutrients can influence on body weight through their interactions with FTO gene polymorphisms. This study aimed to investigate the association between FTO gene rs9939609 polymorphism with macro-nutrients intake.Methods This cross-sectional study was carried out on 196 overweight adults. The rs9939609 SNP in FTO was genotyped. Dietary intake was assessed by a valid 168-item semi-quantitative food frequency questionnaire (FFQ). The association between dietary macro-nutrients and the FTO genotype were assessed using linear regression after adjustments for sex, age, physical activity, triglycerides, fasting blood sugar (FBS), and low density lipoprotein (LDL).Results The higher carbohydrates (p=0.000), fat intake (p=0.009) and calorie intake (p=0.001) were significantly associated with FTO gene risk allele (P=0.001). Carriers of the AA/AG genotype of rs9939609 had significantly higher calorie, fat, and carbohydrate intake than the carriers of the TT genotype (p=0.019, p=0.010, & p=0.000, respectively).Conclusion The dietary carbohydrate and fat intake were associated with FTO genotype. Further studies are warranted to investigation of these interactions and the underlying mechanisms.

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Macronutrient Intake as a Mediator with FTO to Increase Body Mass Index

Abstract: These findings suggest that in adults, the relationship between FTO variants and BMI is not primarily through mediation of food intake.

Cited by 12 publications

References 27 publications

The FTO Gene and Measured Food Intake in 5‐ to 10‐Year‐Old Children Without Obesity

The FTO Gene and Measured Food Intake in 5‐ to 10‐Year‐Old Children Without Obesity

Dietary fat intake modifies the influence of the FTO rs9939609 polymorphism on adiposity in adolescents: The HELENA cross-sectional study

The association between FTO genotype and macro-nutrients’ intake in overweight adults

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