Macronodular bilateral adrenal hyperplasia: diagnose the aberrant receptors and current aspects of treatment

Yukina, Marina; Nuralieva, Nurana; Beltsevich, Dmitry; Трошина, Е. А.; Платонова, Н. М.

doi:10.26442/2075-1753_2016.10.29-33

Cited by 2 publications

(1 citation statement)

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“…На данный момент обнаружение аберрантных рецепторов возможно как при проведении специальных проб на дооперационном этапе, так и при выполнении ИГХ-исследования, количественной ПЦР с обратной транскрипцией послеоперационного материала. Проведение физиологических (ортостатическая проба, проба со смешанной пищей) и фармакологических тестов (пробы с метоклопрамидом, цизапридом, аргинином-вазопрессином/терлипрессином, бусерелином, глюкагоном, АКТГ 1-24, тирогеном) могут использоваться для диагностики МДГН на наличие аберрантных GPCR до оперативного лечения [14]. Однако наибольшую клиническую значимость тесты имели вплоть до 2015 г., когда единственным эффективным методом лечения гиперкортицизма при МДГН считалась двусторонняя адреналэктомия.…”

Section: Introductionunclassified

Immunohistochemical study on the expression/hyperexpression of aberrant/eutopic receptors in patients with bilateral macronodular adrenal hyperplasia

Chevais

Selivanova

Kuznetzov

et al. 2020

Probl Endokrinol (Mosk)

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Bilateral macronodular adrenal hyperplasia (BMAH) is a rare cause of Cushing’s syndrome. In this case cortisol production can be regulated by both genetic factors and various molecular mechanisms. The presence of aberrant or overexpression of eutopic receptors on the membrane of adrenal cortex may lead to activation of cAMP/PKA signaling pathways and consequently, pathological stimulation of steroidogenesis. Since proving the effectiveness of unilateral adrenalectomy in BMAH by achievement of stable remission, preoperative clinical and laboratory tests (ligand-induced tests) are no longer of relevant. Nevertheless, in the absence of normalization of the level of cortisol in the postoperative period or its recurrence, subsequent specific targeted medical options can be offered only if expression/hyperexpression predominance of one or another receptor. Their detection becomes possible using more reliable diagnostic methods such as polymerase chain reaction (PCR) and immunohistochemical studies (IHC) than clinical laboratory tests. At the moment, PCR has gained a wider application. This article summarizes data on the use of immunohistochemical study in BMAH.

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Section: Introductionunclassified

Immunohistochemical study on the expression/hyperexpression of aberrant/eutopic receptors in patients with bilateral macronodular adrenal hyperplasia

Chevais

Selivanova

Kuznetzov

et al. 2020

Probl Endokrinol (Mosk)

View full text Add to dashboard Cite

show abstract

The role of anthropogenic impact and natural habitat conditions in the reproduction of semi-passable and mass river fish of the lower reaches of the Volga River according to retrospective data

Chavychalova

Taradina

Vasilchenko

et al. 2021

Rybovodstvo I Rybnoe Hozjajstvo (Fish Breeding and Fisheries)

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A retrospective review of the main factors that caused the decline in the reproduction of semi-passable fish in the lower reaches of the Volga River is given. Long-term data on the yield of juvenile semi-passable and river fish are presented, on the basis of which the current state of natural reproduction of roach, carp is estimated as low; bream, bluefin and perch — satisfactory; crucian carp, gaster and rudd — safe. Overregulation of the Volga River flow near Volgograd violated the natural conjugacy of water and temperature regimes. In the regulated period, the timing of the onset of spawning temperature in most cases is ahead of the flooding of the strips. The lag of the delta spawning grounds begins when the runoff is less than 120 km³ and reaches the maximum values (up to 27 days) in years with extremely low water content. The delay in flooding of spawning grounds in conditions of unsatisfactory water content leads to the accumulation of producers in limited areas of strips and simultaneous spawning of fish with different ecology. This leads to increased food competition of the larvae and reduced survival. After the flow was regulated, the rates of rise and fall of the hollow waters increased by 2 times, the hatching of the larvae, as a rule, coincided with the onset of the flow of the hollow waters. The mass removal of larvae into the delta watercourses at the early stages of ontogenesis, due to their lack of viability in river conditions, leads to a decrease in the productivity of spawning grounds. In the modern period (2003– 2019), due to the predominance of unfavorable hydrological regime, the duration of high water and flooding of the poloi years, and in order to clarify the yield of juvenile fish in the lower reaches of the Volga, its accounting was carried out not only in the poloi of the delta, but also in the coastal watercourses (where a large number of larvae and fry that rolled off the poloi and from local spawning), in the kultuch zone and on the poloi of the lower zone of the Volga-Akhtuba floodplain.

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Macronodular bilateral adrenal hyperplasia: diagnose the aberrant receptors and current aspects of treatment

Cited by 2 publications

References 0 publications

Immunohistochemical study on the expression/hyperexpression of aberrant/eutopic receptors in patients with bilateral macronodular adrenal hyperplasia

Immunohistochemical study on the expression/hyperexpression of aberrant/eutopic receptors in patients with bilateral macronodular adrenal hyperplasia

The role of anthropogenic impact and natural habitat conditions in the reproduction of semi-passable and mass river fish of the lower reaches of the Volga River according to retrospective data

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