Macromolecule-based hydrogels nanoarchitectonics with mesenchymal stem cells for regenerative medicine: A review

Tian, Bingren; Liu, Jiayue; Guo, Shaofeng; Li, A.; Wan, Jian‐Bo

doi:10.1016/j.ijbiomac.2023.125161

Cited by 9 publications

(2 citation statements)

References 128 publications

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“…In this context, the cell-loaded hydrogels have been extensively employed in tissue engineering and regenerative medicine, mimicking the physical and chemical attributes of the extracellular microenvironment. 29 – 31 …”

Section: Introductionmentioning

confidence: 99%

Delivery of dental pulp stem cells by an injectable ROS-responsive hydrogel promotes temporomandibular joint cartilage repair via enhancing anti-apoptosis and regulating microenvironment

Ma,

Li,

Wei

et al. 2024

J Tissue Eng

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Temporomandibular joint (TMJ) cartilage repair poses a considerable clinical challenge, and tissue engineering has emerged as a promising solution. In this study, we developed an injectable reactive oxygen species (ROS)-responsive multifunctional hydrogel (RDGel) to encapsulate dental pulp stem cells (DPSCs/RDGel in short) for the targeted repair of condylar cartilage defect. The DPSCs/RDGel composite exhibited a synergistic effect in the elimination of TMJ OA (osteoarthritis) inflammation via the interaction between the hydrogel component and the DPSCs. We first demonstrated the applicability and biocompatibility of RDGel. RDGel encapsulation could enhance the anti-apoptotic ability of DPSCs by inhibiting P38/P53 mitochondrial apoptotic signal in vitro. We also proved that the utilization of DPSCs/RDGel composite effectively enhanced the expression of TMJOA cartilage matrix and promoted subchondral bone structure in vivo. Subsequently, we observed the synergistic improvement of DPSCs/RDGel composite on the oxidative stress microenvironment of TMJOA and its regulation and promotion of M2 polarization, thereby confirmed that M2 macrophages further promoted the condylar cartilage repair of DPSCs. This is the first time application of DPSCs/RDGel composite for the targeted repair of TMJOA condylar cartilage defects, presenting a novel and promising avenue for cell-based therapy.

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Section: Introductionmentioning

confidence: 99%

Delivery of dental pulp stem cells by an injectable ROS-responsive hydrogel promotes temporomandibular joint cartilage repair via enhancing anti-apoptosis and regulating microenvironment

Ma,

Li,

Wei

et al. 2024

J Tissue Eng

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show abstract

“…In addition, the strategies to date suffer from limited stem cell adhesion, increased apoptosis after administration, and impaired regenerative functions. [9] In the 40 years of research on structural design and fabrication, DNA nanotechnology has been employed to develop nanometer to micrometer-scaled materials with versatile biological functions and therapeutic applications. [10] A variety of functional biomolecules can be attached to the artificial DNA structures and devices in a sequence-specific fashion.…”

Section: Introductionmentioning

confidence: 99%

Self‐Assembled DNA Composite‐Engineered Mesenchymal Stem Cells for Improved Skin‐Wound Repair

Li,

Wang,

Wang

et al. 2024

Small

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The direct use of mesenchymal stem cells (MSCs) as therapeutics for skin injuries is a promising approach, yet it still faces several obstacles, including limited adhesion, retention, and engraftment of stem cells in the wound area, as well as impaired regenerative and healing functions. Here, DNA‐based self‐assembled composites are reported that can aid the adhesion of MSCs in skin wounds, enhance MSC viability, and accelerate wound closure and re‐epithelialization. Rolling‐circle amplification (RCA)‐derived DNA flowers, equipped with multiple copies of cyclic Arg‐Gly‐Asp (cRGD) peptides and anti‐von Willebrand factor (vWF) aptamers, act as robust scavengers of reactive oxygen species (ROS) and enable synergistic recognition and adhesion to stem cells and damaged vascular endothelial cells. These DNA structure‐aided stem cells are retained at localized wound sites, maintain repair function, and promote angiogenesis and growth factor secretion. In both normal and diabetes‐prone db/db mice models with excisional skin injuries, facile topical administration of DNA flower‐MSCs elicits rapid blood vessel formation and enhances the sealing of the wound edges in a single dose. DNA composite‐engineered stem cells warrant further exploration as a new strategy for the treatment of skin and tissue damage.

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Interface‐Interactive Nanoarchitectonics: Solid and/or Liquid

Ariga

2024

ChemPhysChem

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The methodology of nanoarchitectonics is to construct functional materials using nanounits such as atoms, molecules, and nanoobjects, just like architecting buildings. Nanoarchitectonics pursues the ultimate concept of materials science through the integration of related fields. In this review paper, under the title of interface‐interactive nanoarchitectonics, several examples of structure fabrication and function development at interfaces will be discussed, highlighting the importance of architecting materials with nanoscale considerations. Two sections provide some examples at the solid and liquid surfaces. In solid interfacial environments, molecular structures can be precisely observed and analyzed with theoretical calculations. Solid surfaces are a prime site for nanoarchitectonics at the molecular level. Nanoarchitectonics of solid surfaces has the potential to pave the way for cutting‐edge functionality and science based on advanced observation and analysis. Liquid surfaces are more kinetic and dynamic than solid interfaces, and their high fluidity offers many possibilities for structure fabrications by nanoarchitectonics. The latter feature has advantages in terms of freedom of interaction and diversity of components, therefore, liquid surfaces may be more suitable environments for the development of functionalities. The final section then discusses what is needed for the future of material creation in nanoarchitectonics.

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Macromolecule-based hydrogels nanoarchitectonics with mesenchymal stem cells for regenerative medicine: A review

Cited by 9 publications

References 128 publications

Delivery of dental pulp stem cells by an injectable ROS-responsive hydrogel promotes temporomandibular joint cartilage repair via enhancing anti-apoptosis and regulating microenvironment

Delivery of dental pulp stem cells by an injectable ROS-responsive hydrogel promotes temporomandibular joint cartilage repair via enhancing anti-apoptosis and regulating microenvironment

Self‐Assembled DNA Composite‐Engineered Mesenchymal Stem Cells for Improved Skin‐Wound Repair

Interface‐Interactive Nanoarchitectonics: Solid and/or Liquid

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