Macromolecule and water magnetization exchange modeling in articular cartilage

Lattanzio, Pierre-Jean; Marshall, K. W.; Damyanovich, A.; Peemoeller, H.

doi:10.1002/1522-2594(200012)44:6<840::aid-mrm4>3.0.co;2-k

Cited by 87 publications

(103 citation statements)

References 38 publications

(51 reference statements)

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“…Sled and Pike proposed a two-pool MT model for pulsed imaging to simplify Equations [1][2][3][4][5][6][7] (9,10). Here, we extend their model for multispoke pulsed imaging (i.e., one MT pulse preparation followed by multiple acquisitions) to reduce the data acquisition time (Fig.…”

Section: Two-pool Model Parameter Estimationmentioning

confidence: 99%

“…On the other hand, the effect of the MT pulse on the water pool is modeled as an instantaneous fractional saturation of the longitudinal magnetization. Such instantaneous satration ðS 1w Þ is estimated by numerically solving Equations [1], [3], and [4] when R and R 1w are set to 0. For the excitation pulses, the instantaneous saturation of water component is cos Nsp ðaÞ, where a is the excitation flip angle and N sp is the number of spokes or excitations after each MT pulse preparation.…”

Section: Two-pool Model Parameter Estimationmentioning

confidence: 99%

“…We used the following MT parameters to compare our modified RP model with both the original Sled and Pike RP model and conventional CWPE model (11) with Bloch simulations from Equations [1][2][3][4]. The following parameters were used in the simulation:…”

Section: Numerical Simulationsmentioning

confidence: 99%

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Quantitative magnetization transfer ultrashort echo time imaging using a time‐efficient 3D multispoke Cones sequence

Chang

Carl³

et al. 2017

Magnetic Resonance in Med

146

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Purpose: To accelerate the quantitative ultrashort echo time imaging using a time-efficient 3D multispoke Cones sequence with magnetization transfer (3D UTE-Cones-MT) and signal modeling. Theory and Methods: A 3D UTE-Cones-MT acquisition scheme with multispoke per MT preparation and a modified rectangular pulse (RP) approximation was developed for twopool MT modeling of macromolecular and water components including their relative fractions, relaxation times and exchange rates. Numerical simulation and cadaveric specimens, including human Achilles tendon and bovine cortical bone, were investigated using a clinical 3T scanner. Results: Numerical simulation showed that the modified RP model provided accurate estimation of MT parameters when multispokes were acquired per MT preparation. For the experiment with the Achilles tendon and cortical bone samples, the macromolecular fractions were 20.4 6 2.0% and 59.4 6 5.3%, respectively. Conclusion: The 3D multispoke UTE-Cones-MT sequence can be used for fast volumetric assessment of macromolecular and water components in short T 2 tissues.

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Section: Two-pool Model Parameter Estimationmentioning

confidence: 99%

Section: Two-pool Model Parameter Estimationmentioning

confidence: 99%

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Quantitative magnetization transfer ultrashort echo time imaging using a time‐efficient 3D multispoke Cones sequence

Chang

Carl³

et al. 2017

Magnetic Resonance in Med

146

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“…The majority of the water in cartilage exists in the form of free water, with a smaller fraction bound to either PGs or collagen fibrils (9,10). Bound water has a much shorter T2 than free water (10).…”

Section: Mr Data Acquisitionmentioning

confidence: 99%

Ultrashort–Echo Time MR Imaging of the Patella with Bicomponent Analysis: Correlation with Histopathologic and Polarized Light Microscopic Findings

Pauli¹,

Bae²,

Lee³

et al. 2012

Radiology

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Purpose:To correlate short and long T2* water fractions, derived from ultrashort-echo time (TE) magnetic resonance (MR) imaging, with semiquantitative histopathologic and polarized light microscopic (PLM) assessment of human cadaveric patellae cartilage. Materials and Methods:Twenty human cadaveric patellae were evaluated by using ultrashort-TE imaging, spin-echo imaging, histopathologic analysis, and PLM, with institutional review board approval. Short and long T2* water components were evaluated for each patella by using bicomponent fitting of ultrashort-TE signal decay. Four to six regions of interest (ROIs) within each patella were chosen for correlation between ultrashort-TE bicomponent analysis, histopathologic grading (Mankin score), and PLM grading (Vaudey score). Results:Ultrashort-TE imaging with bicomponent analysis showed two distinct water components with a short T2* and a longer T2* in all patellae. ROI analysis showed that the short T2* fraction was correlated significantly with the Mankin (r = 0.66, P , .001) and Vaudey (r = 0.68, P , .001) scores. The Mankin scores were weakly positively correlated with T2 (r = 0.28, P = .13) and short T2* (r = 0.24, P = .14) but were negatively correlated with long T2* (r = 20.55, P , .01). The Vaudey scores were weakly positively correlated with T2 (r = 0.18, P = .16) and short T2* (r = 0.22, P = .14) but were negatively correlated with long T2* (r = 20.55, P , .01). Conclusion:Short T2* water fraction derived from ultrashort-TE imaging with bicomponent analysis correlates significantly with both the Mankin and Vaudey scores and may serve as a biomarker of cartilage degeneration.q RSNA, 2012

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“…Biological tissues frequently contain different water compartments, and these often have distinct transverse relaxation times (T 2 ) or apparent transverse relaxation times (T 2 *) (1)(2)(3)(4)(5)(6)(7)(8). Clinical techniques for determining the relaxation times of such multiple components are usually based on exponential fitting of data obtained from spin echo images acquired with Carr-Purcell-Meiboon-Gill sequences (1-10).…”

mentioning

confidence: 99%

Ultrashort echo time imaging with bicomponent analysis

Diaz

Carl

et al. 2011

Magnetic Resonance in Med

124

142

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Biological tissues frequently contain different water compartments, and these often have distinct transverse relaxation times. Quantification of these may be problematic on clinical scanners because spin echo sequences usually have initial echo times that are too long to accurately quantify shorter relaxation time components. In this study, an ultrashort echo time pulse sequence was used together with bicomponent analysis to quantify both the short and long T 2 components in tissues of the musculoskeletal system. Feasibility studies were performed using numerical simulation, and on phantoms and in vitro tissues including bovine cortical bone, ligaments, menisci, tendons, and articular cartilage. The simulation and phantom studies demonstrated that this technique can quantify T 2 * and fractions of the short and long T 2 components. The tissues studies showed two distinct components with short T 2 *s ranging from 0.3 ms for bovine cortical bone to 2.1 ms for menisci, and long T 2 *s ranging from 2.9 ms for bovine cortical bone to 35.0 ms for articular cartilage. The short T 2 * fraction ranged from 18.5% for patella cartilage to 80.9% for ligaments. The results show that ultrashort echo time imaging with bicomponent analysis can quantify the short and long T 2 water components in vitro in musculoskeletal tissues. Magn Reson Med 67:645-649,

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Macromolecule and water magnetization exchange modeling in articular cartilage

Cited by 87 publications

References 38 publications

Quantitative magnetization transfer ultrashort echo time imaging using a time‐efficient 3D multispoke Cones sequence

Quantitative magnetization transfer ultrashort echo time imaging using a time‐efficient 3D multispoke Cones sequence

Ultrashort–Echo Time MR Imaging of the Patella with Bicomponent Analysis: Correlation with Histopathologic and Polarized Light Microscopic Findings

Ultrashort echo time imaging with bicomponent analysis

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