Macromolecularly “Caged” Carbon Nanoparticles for Intracellular Trafficking via Switchable Photoluminescence

Misra, Santosh K.; Srivastava, Indrajit; Tripathi, Indu; Daza, Enrique; Ostadhossein, Fatemeh; Pan, Dipanjan

doi:10.1021/jacs.6b11595

Cited by 73 publications

(55 citation statements)

References 27 publications

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“…Our findings of excitation dependent and red shifted optical properties are in good agreement with earlier reports ,,. It is anticipated that effective conjugation of –C=C– group combined with increasing degree of surface oxidation in CDs could account for the large amount red shifting in FL spectra upon different excitation ,,. It is interesting to note that optical analysis of CDs showed CDs are multicolor in nature due to characteristic surface functionalities along with excitation dependent red shifted emission.…”

Section: Resultsmentioning

confidence: 99%

Green Synthesis of Carbon Dot Weak Gel from Pear Juice: Optical Properties and Sensing Application

Mondal

Srivastava

2018

ChemistrySelect

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Herein, we report for the first time a low-cost and eco-friendly carbon dot weak gel (CDWG) in the absence of any gelling agent from a pear juice as a green precursor. Our findings showed that the volatile nature of acetone, basic media, and cellulose content in pear juice played key roles in the formation of CDWG. This fabrication strategy of CDWG from a green precursor in absence of gelling agent could be more advantageous over CD-hybrids gel. Further, the fabricated gel exhibited excitation dependent red shifted multicolor (blue-green-yellow-orange) emission due to the presence of characteristic hydrophilic surface in CDs. The other unique feature of the work involved utilization of inherent fluorescent property of CDs in establishing optical interaction between 0D CDWG and 2D reduced graphene oxide (G) and graphene oxide (GO). It may be concluded that the quenching is mainly guided by the electron rich CDs and electron acceptance ability, large specific surface area of G and GO. It is also interesting to note that the introducing of gel property in CDs exhibit improved sensing efficiency and limit of detection of CDWG (1.5 μg ml À 1 ) for G. Further, such optical sensing could be beneficial for the fabrication of optoelectronics, photovoltaic devices and sensing of bio-molecules and metal ions.[a] J.

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Section: Resultsmentioning

confidence: 99%

Green Synthesis of Carbon Dot Weak Gel from Pear Juice: Optical Properties and Sensing Application

Mondal

Srivastava

2018

ChemistrySelect

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“…The intensity of I D / I G was found to increase from 0.89 to 1.12 from CNP BI1 to CNP BI6 which could be attributed that the amorphous structures of CNPs are closely correlated to the red shift in PL emission . The FT‐IR spectra shown in Figure B reveal that all the passivated CNP BIs possessed abundant hydrophilic groups such as OH and NH (3425 cm −1 ), and COOH (1680 cm −1 ) on their surface ensuring their dispersibility in aqueous media . One interesting feature is the increase in the OH vibration bands at ≈3400 cm −1 .…”

Section: Resultsmentioning

confidence: 99%

“…Number of reports points to the fact these artificial band gaps lead characteristics strong UV absorption, blue‐to‐green PL, excitation‐energy‐dependent PL, etc. We and others have previously confirmed that the tunability of color of PL is directly associated with the energy gap between two different energy levels primarily originating from their surface states . CNPs are known to possess a variety of surface functional groups, defects, and adsorbates .…”

Section: Introductionmentioning

confidence: 94%

In Situ Time‐Dependent and Progressive Oxidation of Reduced State Functionalities at the Nanoscale of Carbon Nanoparticles for Polarity‐Driven Multiscale Near‐Infrared Imaging

et al. 2018

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Surface abundant oxidize‐able functionalities at the nanoscale of carbon dots are prone to undergo sequential aerial oxidation leading to polarity‐driven wavelength tuning of their photoluminescence and consequently boost their quantum yields. With the progression of time, aerial oxidation is gradually increased from 1 to 6 h; consequently, a remarkable shift in the emission peak is observed, likely due to a gradual decrease in their respective band gaps leading to red shift of their photoluminescence. These bands are found to be dependent on the time of hydrothermal treatment of the model small molecules, i.e., benzophenone imine, and not on the size of the carbon core, as is the typical case for semiconductor quantum dots. Due to their high quantum yield (≈31%), it is demonstrated that these wavelength‐tuned carbon nanoparticles can be efficiently used for multiscale bioimaging, i.e., intracellular, deep tissue ex vivo and in vivo fluorescence bioimaging.

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“…Regarding PCa and BC applications utilizing carbon-based NPs there is an increasing number of publications during the last couple of years, both for imaging and therapy but also for different kind of electrochemical biosensor systems [226,227,228,229,230,231,232,233,234]. For instance, regarding PCa, Heydari-Bafrooei et al and Pan et al have both developed different kind of CNT-based biosensor systems able to detect prostate specific antigen (PSA) in serum and vascular endothelial growth factor (VEGF) and PSA in serum, respectively, for early diagnosis of PCa [227,229].…”

Section: Nanoparticles For Prostate and Breast Cancermentioning

confidence: 99%

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer

Elgqvist

2017

IJMS

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Prostate and breast cancer are the second most and most commonly diagnosed cancer in men and women worldwide, respectively. The American Cancer Society estimates that during 2016 in the USA around 430,000 individuals were diagnosed with one of these two types of cancers, and approximately 15% of them will die from the disease. In Europe, the rate of incidences and deaths are similar to those in the USA. Several different more or less successful diagnostic and therapeutic approaches have been developed and evaluated in order to tackle this issue and thereby decrease the death rates. By using nanoparticles as vehicles carrying both diagnostic and therapeutic molecular entities, individualized targeted theranostic nanomedicine has emerged as a promising option to increase the sensitivity and the specificity during diagnosis, as well as the likelihood of survival or prolonged survival after therapy. This article presents and discusses important and promising different kinds of nanoparticles, as well as imaging and therapy options, suitable for theranostic applications. The presentation of different nanoparticles and theranostic applications is quite general, but there is a special focus on prostate cancer. Some references and aspects regarding breast cancer are however also presented and discussed. Finally, the prostate cancer case is presented in more detail regarding diagnosis, staging, recurrence, metastases, and treatment options available today, followed by possible ways to move forward applying theranostics for both prostate and breast cancer based on promising experiments performed until today.

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Macromolecularly “Caged” Carbon Nanoparticles for Intracellular Trafficking via Switchable Photoluminescence

Cited by 73 publications

References 27 publications

Green Synthesis of Carbon Dot Weak Gel from Pear Juice: Optical Properties and Sensing Application

Green Synthesis of Carbon Dot Weak Gel from Pear Juice: Optical Properties and Sensing Application

In Situ Time‐Dependent and Progressive Oxidation of Reduced State Functionalities at the Nanoscale of Carbon Nanoparticles for Polarity‐Driven Multiscale Near‐Infrared Imaging

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer

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