Macromolecular Information Transfer

Samokhvalova, Svetlana; Lutz, Jean‐François

doi:10.1002/anie.202300014

Cited by 10 publications

(9 citation statements)

References 105 publications

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“…The diverse biomacromolecular functions enabled by precisely controlled monomer sequences motivated polymer chemists to make efforts to develop methodologies to prepare sequence-defined synthetic analogs to elucidate the sequence-structure–function relationships. ,, Strategies such as solid/liquid-phase synthesis, ,− templated polymerization, − single unit monomer insertion , and iterative exponential growth , were explored to achieve monomer sequence control in oligomeric or low molecular weight polymeric products. Sequence-defined polyphosphates, poly(alkoxyamine amides), and polyurethanes hold promise in secure data storage as molecular barcodes and QR codes. − Discrete block copolymers containing immiscible segments (e.g., PLA and polydimethylsiloxane (PDMS)) provide an ideal model for phase separation studies to resolve the impact of atomic-level alteration on phase behaviors.…”

Section: Sequencementioning

confidence: 99%

Design of Microstructure-Engineered Polymers for Energy and Environmental Conservation

Yang

Cao

Chen

et al. 2023

JACS Au

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With the ever-growing demand for sustainability, designing polymeric materials using readily accessible feedstocks provides potential solutions to address the challenges in energy and environmental conservation. Complementing the prevailing strategy of varying chemical composition, engineering microstructures of polymer chains by precisely controlling their chain length distribution, main chain regio-/stereoregularity, monomer or segment sequence, and architecture creates a powerful toolbox to rapidly access diversified material properties. In this Perspective, we lay out recent advances in utilizing appropriately designed polymers in a wide range of applications such as plastic recycling, water purification, and solar energy storage and conversion. With decoupled structural parameters, these studies have established various microstructure−function relationships. Given the progress outlined here, we envision that the microstructure-engineering strategy will accelerate the design and optimization of polymeric materials to meet sustainability criteria.

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Section: Sequencementioning

confidence: 99%

Design of Microstructure-Engineered Polymers for Energy and Environmental Conservation

Yang

Cao

Chen

et al. 2023

JACS Au

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“…Digital polymers are unique sequence-defined polymers that can store information in their chains using a controlled sequence of monomers. − Inspired by deoxyribonucleic acid biopolymers that store genetic information in living systems, − research on digital synthetic polymers has recently gained increasing attention in polymer and material sciences. − The development of digital polymers with high-density information storage, efficient information encoding, and reliable information decoding is highly desirable. These three valuable characteristics depend significantly on the structure of the monomers used.…”

Section: Introductionmentioning

confidence: 99%

“…Tandem mass spectrometry (MS/MS) is currently the most widely used technique for sequencing general digital polymers, − ,− although the primary mass spectrum , and nanopore technique , have been demonstrated to sequence few types of digital polymers with specific molecular structures. In the MS/MS technique, the polymer backbone is cleaved to form various chain fragments.…”

Section: Introductionmentioning

confidence: 99%

Digital Polymers Based on Cyclic Monomers

Ren,

Ding,

et al. 2024

Macromolecules

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The preparation of digital polymers with high information storage density, efficient information encoding, and easy information decoding characteristics is challenging. Using small cyclic compounds, such as δ-valerolactones, β-amino acid Nthiocarboxyanhydrides, and anhydrides, as monomers, we developed iterative growth methods to prepare novel types of digital polymers. The use of small cyclic monomers provides significant advantages for iterative growth methods and the resulting digital polymers. First, small cyclic monomers with a large variety of side group structures can be easily obtained, which significantly expands the monomer alphabet and increases the information storage density of the digital polymers produced (reaching 0.023 bit/Da). Second, small cyclic monomers contain self-protected reactive groups, eliminating the need for protective groups or orthogonal reactive−group pairs. These cyclic monomers also exhibit high nucleophilic ring-opening reactivity under mild reaction conditions, facilitating the use of new efficient iterative growth methods to encode information. Third, the simple ring structure of cyclic monomers results in digital polymers with simple backbone structures that contain only two types of functional groups: esters and amides. As a result, the encoded information can be easily and reliably decoded by using tandem mass spectrometry sequencing, selectively cleaving ester bonds with lower dissociation energies. This study demonstrates that small cyclic monomer codes are promising for the development of efficient iterative growth methods to prepare high-storage-density digital polymers with easy and reliable readability.

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“…[10][11][12] However, there is potential to extend molecular evolution techniques to synthetic systems and access new regions of unexplored chemical space. 13,14 The physicochemical properties of such synthetic oligomers will depend on the chemical structure of the backbone and the functional groups that encode information, allowing exploitation in different environments from nucleic acids, i.e. in organic solvents, low temperature, etc.…”

Section: Introductionmentioning

confidence: 99%