Macromol. Rapid Commun. 19/2008

Kim, GeunHyung; Csontos, János; Park, Sua; Kim, WanDoo

doi:10.1002/marc.200890038

Cited by 26 publications

(29 citation statements)

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“…The result is coincident with that of Sachlos and Czernuszka, who reported that increasing the pore size or porosity decreases the compressive modulus of the scaffold [3]. Recently, the RP process was combined with various fabrication processes, such as electrospinning [11,12] and freeze-drying techniques [13], and the fabricated hybrid scaffolds improved initial cell attachment and proliferation as compared to a general 3-D scaffold. Detailed comparisons for various 3-D scaffold fabricating methods including RP technology have been well described in Ref.…”

Section: Introductionsupporting

confidence: 83%

Three-Dimensional Plotter Technology for Fabricating Polymeric Scaffolds with Micro-grooved Surfaces

Csontos

Kim

2009

Journal of Biomaterials Science, Polymer Edition

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Various mechanical techniques have been used to fabricate biomedical scaffolds, including rapid prototyping (RP) devices that operate from CAD files of the target feature information. The three-dimensional (3-D) bio-plotter is one RP system that can produce design-based scaffolds with good mechanical properties for mimicking cartilage and bones. However, the scaffolds fabricated by RP have very smooth surfaces, which tend to discourage initial cell attachment. Initial cell attachment, migration, differentiation and proliferation are strongly dependent on the chemical and physical characteristics of the scaffold surface. In this study, we propose a new 3-D plotting method supplemented with a piezoelectric system for fabricating surface-modified scaffolds. The effects of the physically-modified surface on the mechanical and hydrophilic properties were investigated, and the results of cell culturing of chondrocytes indicate that this technique is a feasible new method for fabricating high-quality 3-D polymeric scaffolds.

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Section: Introductionsupporting

confidence: 83%

Three-Dimensional Plotter Technology for Fabricating Polymeric Scaffolds with Micro-grooved Surfaces

Csontos

Kim

2009

Journal of Biomaterials Science, Polymer Edition

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“…These nanofibrous structures have been widely explored for use in tissue engineering due to their high porosity and good surface area-to-volume ratio as well as their topographical features which enhance cellular adhesion, migration, and proliferation. [12][13][14] Since the nanofiberous scaffold is extremely long, entangled, and densely packed into a 2-D structure on the surface, it is difficult for the electrospun nanofibers to be shaped into porous 3-D architecture for tissue engineering scaffold. In order to produce a highly macroporous construct that also provides a nanofibrous structure, we first developed PLLA nanocylinders by aminolysis and ultra-sonication process.…”

Section: Introductionmentioning

confidence: 99%

Poly(L-lactic acid) Nanocylinders as Nanofibrous Structures for Macroporous Gelatin Scaffolds

Lee¹,

Jeong²,

Bae³

et al. 2011

J. Nanosci. Nanotech.

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Electrospun Nanofiber sheets have been shown to mimic the structure of extracellular matrix (ECM). Although these nanofibers have shown great potential for use as tissue engineering scaffolds, it is difficult for the electrospun nanofiber based sheets to be shaped into the desired three-dimensional structure. In this study, poly(L-lactic acid) (PLLA), a biodegradable and biocompatible polyester, was electrospun to produce nanofibers that were treated with an amino group containing base in order to fabricate polymeric nanocylinders. The aspect ratio of the PLLA nanocylinders was tunable by varying the aminolysis time and density of the amino group containing base. The effects of changes in nanofibrous morphology of the PLLA nanocylinders/macro-porous gelatin scaffolds on cell adhesion and proliferation were evaluated. The results revealed different cell morphology, adhesion, and proliferation in the nanocylinders composite gelatin scaffold versus gelatin scaffold alone. Confocal laser scanning microscopy observation showed more spreading and a more flattened cell morphology after NIH3T3 cells were cultured on PLLA nanocylinders/gelatin scaffolds for 10 hours and 4 days. These results indicate that the gelatin/PLLA nanocylinder composite is a promising way to fabricate 3D nanofibrous scaffolds that accelerates cell adhesion and proliferation for tissue engineering.

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“…As mentioned above, electrospinning of bioerodible polymers is well known. There are not many efforts in the literature to make short electrospun fibers 40. Previously we used mechanical cutting, UV cutting method for getting short fibers 41, 42…”

Section: Introductionmentioning

confidence: 99%

Electrospinning and cutting of ultrafine bioerodible poly(lactide‐co‐ethylene oxide) tri‐ and multiblock copolymer fibers for inhalation applications

Thieme

Agarwal

Wendorff

et al. 2011

Polymers for Advanced Techs

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Triblock copolymers made up of poly(ethylene oxide) (PEO) and polylactide (PLA) were synthesized and converted to fibers by the electrospinning process. A two‐step in situ‐synthesis in bulk was applied to extend PLA‐PEO‐PLA triblock copolymers with relatively short block length and low molecular weight in order to obtain electrospinnable materials. DL‐lactide was polymerized to the hydroxyl chain ends of PEO via the stannous octoate route. Hexamethylene diisocyanate (HDI) was added as chain extender in the second step, leading to poly(ether‐ester‐urethane) multiblock copolymers. The materials were electrospun from solutions in chloroform. Different concentrations and voltages were analyzed. The ether and ester blocks were varied in their block length and their effects on the fiber morphology was studied. Variations in the electrical conductivity of the chloroform solutions were investigated by adding triethyl benzyl ammonium chloride (TEBAC) in different amounts. Finally, with high quality electrospun PLA‐PEO‐PEO triblock copolymer fibers mechanical cutting was possible. Copyright © 2009 John Wiley & Sons, Ltd.

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Macromol. Rapid Commun. 19/2008

Cited by 26 publications

References 0 publications

Three-Dimensional Plotter Technology for Fabricating Polymeric Scaffolds with Micro-grooved Surfaces

Three-Dimensional Plotter Technology for Fabricating Polymeric Scaffolds with Micro-grooved Surfaces

Poly(L-lactic acid) Nanocylinders as Nanofibrous Structures for Macroporous Gelatin Scaffolds

Electrospinning and cutting of ultrafine bioerodible poly(lactide‐co‐ethylene oxide) tri‐ and multiblock copolymer fibers for inhalation applications

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