Macromol. Rapid Commun. 17/2014

Liu, Jianzhao; Bauer, Adam J. P.; Li, Bingbing

doi:10.1002/marc.201470061

Cited by 12 publications

(20 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The solvent‐vapor‐annealed neat PCL fibers (prepared from a PCL‐in‐chloroform solution, see Table ) exhibited secondary nanostructures somewhat comparable to neat PCL fibers prepared from a PCL‐in‐chloroform/acetone solution . However, the neat PCL fibers prepared using 1:1 by volume chloroform/acetone solvent are thinner, ≈1 µm in diameter, which allow better arrangements of crystalline lamellae perpendicular to the surface of the fibers, leading to hierarchical nanostructures of better regularity. In contrast, in this paper, to ensure the stable spinability of PCL/PEO solutions, chloroform was chosen to prepare all PCL/PEO blend solutions.…”

Section: Resultsmentioning

confidence: 92%

“…In the past, solvent vapor annealing (SVA) methods have been used to attain desired nanostructures or chain conformations in polymer thin films . In our recent study, a SVA method was adopted to induce the formation of secondary nanostructures on electrospun neat poly(ε‐caprolactone) (PCL) fibers . Free amorphous PCL chains can be delocalized during acetone vapor treatment and then crystalized onto the pre‐existing crystalline lamellae upon solvent evaporation, giving rise to hierarchically nanostructured PCL fibers.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the surface of all fibers can be exposed to the solvent vapor in a uniform and consistent manner, allowing the formation of uniform hierarchical structures across the entire z ‐dimension of the electrospun mat. In this pioneering work, neat PCL fibers, prepared using PCL‐in‐chloroform/acetone solutions, are of several hundred nanometers to about 1 µm in diameter and with sufficient free amorphous chains . During acetone SVA treatment, amorphous chains with a greater free volume can absorb acetone vapor much faster than the chains packed in crystalline regions.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hierarchical Polymer Blend Fibers of High Structural Regularity Prepared by Facile Solvent Vapor Annealing Treatment

Bauer

Grim

2017

Macro Materials & Eng

Self Cite

View full text Add to dashboard Cite

In this study, a facile solvent vapor annealing (SVA) method is utilized to inscribe hierarchical secondary nanostructures onto electrospun poly(ε‐caprolactone)(PCL)/poly(ethylene oxide) (PEO) blend fibers. By carefully understanding the phase separation and crystallization behavior of PCL/PEO blends during the electrospinning process, one can tune the spatial distribution of the PCL phase, the growth of the PCL crystalline regions, and therefore the amount and even the sensitivity of free amorphous PCL chains in response to acetone vapor. Here, the PEO domains serve as mini‐dividers to restrict the growth of the semicrystalline PCL phase. During acetone vapor annealing, the PEO phase remains largely unchanged while swollen‐free amorphous PCL chains are deposited on pre‐existing PCL or even PEO crystalline lamellae, giving rise to hierarchical structures of high regularity. The morphologies of PCL/PEO hierarchical structures reported in this study are of striking uniformity, further demonstrating the reliability of the facile SVA method, not only for a few layers of thin fiber mats but also for thicker fiber mats.

show abstract

Section: Resultsmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hierarchical Polymer Blend Fibers of High Structural Regularity Prepared by Facile Solvent Vapor Annealing Treatment

Bauer

Grim

2017

Macro Materials & Eng

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although different approaches have been attempted to generate electrospun fibers with varied surface nanotopographies, 15,[33][34][35][36][37] in our study the nano-pores-riddled PLLA fibers were simply obtained by use of a highly volatile solvent method. Although different approaches have been attempted to generate electrospun fibers with varied surface nanotopographies, 15,[33][34][35][36][37] in our study the nano-pores-riddled PLLA fibers were simply obtained by use of a highly volatile solvent method.…”

Section: Fabrication Of Aligned Electrospun Plla Fibers With Nanoporomentioning

confidence: 99%

Engineering aligned electrospun PLLA microfibers with nano-porous surface nanotopography for modulating the responses of vascular smooth muscle cells

et al. 2015

View full text Add to dashboard Cite

In tissue engineering research, aligned electrospun ultrafine fibers have been shown to regulate cellular alignment and relevant functional expression, but the imposed effect of individual fiber surface nanotopography on cell behaviour has not been examined closely. This work investigates the impact of superimposing a nano-pore feature atop individual fiber surfaces on the responsive behaviour of human vascular smooth muscle cells (vSMCs) for blood vessel tissue engineering. Well-aligned ultrafine poly(L-lactic acid) (PLLA) microfibers with an average fiber diameter of ca. 1.6 mm were fabricated by using a novel stable jet electrospinning (SJES) method. Ellipse-shaped nano-pores with varied aspect ratios (defined as longto-short axis ratio) of 2.7-3.9, corresponding to a surface nano-roughness in the range of 54.8-110.0 nm, were in situ generated onto individual fiber surfaces by varying ambient humidity from 45% to 75% during the SJES process. The presence of elliptical nano-pores on fiber surfaces affected the characteristic anisotropic wettability of the aligned PLLA fibers and contributed to greater protein adsorption (up to 17.59 mg mg À1 ). A 7 day in vitro assessment of human umbilical arterial SMCs cultured on these aligned nano-porous fiber substrates indicated that cellular responses were in close correlation with the elliptical nano-pore feature. A pronounced fiber surface nanotopography was superior in soliciting favorable cellular responses, leading to enhanced cell attachment, proliferation, alignment, expression of the vascular matrix proteins and maintenance of a contractile phenotype. This study thus suggests that introduction of an elliptical nano-pore feature to the aligned microfiber surfaces could provide additional dimensionality of topographical cues to modulate the vSMC responses when using the aligned electrospun ultrafine fibers for engineering vascular constructs.

show abstract

“…6,7 Ideally, the cross-linking of micelles can be cleaved to release entrapped drugs within target cells in order to overcome possible barrier to drug release from covalent cross-linking structures. [14][15][16] For example, Lam's group prepared thiolated linear-dendritic polymers based disulde cross-linked micelles with a high loading capacity up to 35.5%, which could be triggered to release PTX at the tumor site or in cancer cells. Some environmental-responsive cross-linked micelles have been reported.…”

Section: Introductionmentioning

confidence: 99%

Reversibly cross-linked poly(ethylene glycol)–poly(amino acid)s copolymer micelles: a promising approach to overcome the extracellular stability versus intracellular drug release challenge

Wang

Zhu

et al. 2015

RSC Adv.

View full text Add to dashboard Cite

Reversibly shell cross-linked micelles based on a lipoic acid (LA) decorated triblock copolymer poly(ethylene glycol)-b-poly(g-benzyl-L-glutamate)-b-poly(L-phenylalanine) (PEG-PGlu(EDA-LA)-PPhe) have been developed for active loading and efficient intracellular delivery of DOX. The triblock copolymer was synthesized through consecutive ring-opening polymerization of cyclic monomers gbenzyl-L-glutamate N-carboxyanhydride (BLG-NCA) and L-phenylalanine N-carboxyanhydride (Phe-NCA) using amino-terminated poly(ethylene glycol) (PEG-NH 2 ) as macroinitiator, followed by conjugation with LA for reversible cross-linking. The amphiphilic polymer was self-assembled to core shell corona micelles, which could be further crosslinked in the presence of a catalytic amount of dithiothreitol (DTT) in phosphate buffer (pH 7.4) to form shell-cross-linking micelles (SCLM). The SCLM showed excellent stability under physiological conditions but rapid dissociation and drug release in reductive environments mimicking those of the cytoplasm and the cell nucleus. Confocal laser scanning microscopy further demonstrated that DOX was delivered and released into the nuclei of HeLa cells following 12 h incubation with DOX-loaded SCLM. MTT assays revealed that DOX-loaded SCLM had similar anti-tumor activity as non-cross-linked micelles (NCLM) for HeLa cells following 48 h incubation.PEG-PGlu(EDA-LA)-PPhe micelles displayed low cytotoxicity up to a concentration of 1.0 mg mL À1 .These biodegradable reversibly shell-cross-linked micelles provide a promising platform for intelligent intracellular drug delivery in clinical chemotherapy.Scheme 1 Schematic illustration of the preparation of DOX-loaded PEG-PGlu(EDA-LA)-PPhe crosslinked micelles for reduction responsive intracellular drug release.

show abstract

Macromol. Rapid Commun. 17/2014

Cited by 12 publications

References 0 publications

Hierarchical Polymer Blend Fibers of High Structural Regularity Prepared by Facile Solvent Vapor Annealing Treatment

Hierarchical Polymer Blend Fibers of High Structural Regularity Prepared by Facile Solvent Vapor Annealing Treatment

Engineering aligned electrospun PLLA microfibers with nano-porous surface nanotopography for modulating the responses of vascular smooth muscle cells

Reversibly cross-linked poly(ethylene glycol)–poly(amino acid)s copolymer micelles: a promising approach to overcome the extracellular stability versus intracellular drug release challenge

Contact Info

Product

Resources

About