Macromol. Biosci. 12/2010

Schexnailder, Patrick J.; Gaharwar, Akhilesh K.; Bartlett, Rush L.; Seal, Brandon L.; Schmidt, Gudrun

doi:10.1002/mabi.201090029

Cited by 17 publications

(24 citation statements)

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“…The mechanical and adhesion properties of our hydrogels could be tailored and optimized by balancing covalent cross‐linking via PEGdiacrylate, physical cross‐linking via charged silicate nanoplatelets, and entanglements/mechanical interlocking via dangling PEG chains. The results suggest that these elastomeric and adhesive hydrogels have potential for development as biomaterials for tissue engineering matrixes as they are non‐toxic and also bioadhesive to mammalian cells 28, 31. These materials can also be optimized for use as sealants and wound dressings, for hydrogel bandages and adhesive components of medical devices.…”

Section: Discussionmentioning

confidence: 97%

“…The resulting networks could withstand uniaxial extensions up to 2 000%, indicating that the hydrogel networks can absorb appreciable amounts of energy during deformation. While several studies found that PEG silicate hydrogels support cell growth,30, 31 we discovered that certain formulations showed significant adhesion to surfaces such as metal (13 kPa adhesive strength), glass, plastic and skin 28. Based on these preliminary results, here we present a systematic approach to determine how the mechanical and adhesive properties can be tailored for use as a tissue engineering matrix, wound dressing and pressure sensitive adhesive.…”

Section: Introductionmentioning

confidence: 86%

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Robust and Adhesive Hydrogels from Cross‐Linked Poly(ethylene glycol) and Silicate for Biomedical Use

Wilker

Schmidt

2012

Macromolecular Bioscience

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A systematic approach to develop robust and adhesive hydrogels by photopolymerizing poly(ethylene glycol) (PEG)-diacrylate and methoxy-PEG-acrylate in the presence of charged silicate nanoparticles (Laponite) is presented. PEG-diacrylate and silicate are used for covalent and physical cross-linking, thus providing the hydrogel with mechanical and adhesive strengths. Methoxy-PEG-acrylate is used as a softening agent. The resulting hydrogels can be extensively elongated and the hydrogels readily adhere to tissue even in the elongated state. These hydrogels may aid the development of adhesive tissue engineering matrixes, wound dressings, sealants, and the adhesive components of biomedical devices.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 86%

Robust and Adhesive Hydrogels from Cross‐Linked Poly(ethylene glycol) and Silicate for Biomedical Use

Wilker

Schmidt

2012

Macromolecular Bioscience

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“…In our previous studies we have shown that the cell numbers reached in the plateau phase of the cell growth curves were not a result of contact inhibition between cells 2, 11, 41. Instead, growth inhibition was found to be dependent on the number and distribution of “cell repellant” PEO and “cell adhesive” silicate regions on the nanocomposite films 2, 11, 41. Similar effects are found in the cell growth experiments on fiber surfaces showing that cells are not confluent (Figure 4).…”

Section: Resultsmentioning

confidence: 92%

Highly Extensible Bio‐Nanocomposite Fibers

Gaharwar

Schexnailder

Dundigalla

et al. 2010

Macromol. Rapid Commun.

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Here, we show that a poly(ethylene oxide) polymer can be physically cross-linked with silicate nanoparticles (Laponite) to yield highly extensible, bio-nanocomposite fibers that, upon pulling, stretch to extreme lengths and crystallize polymer chains. We find that both, nanometer structures and mechanical properties of the fibers respond to mechanical deformation by exhibiting strain-induced crystallization and high elongation. We explore the structural characteristics using X-ray scattering and the mechanical properties of the dried fibers made from hydrogels in order to determine feasibility for eventual biomedical use and to map out directions for further materials development.

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“…The fibroblast cells adhesion was increased with the higher silica NPs concentration or with higher PEO crystals in the NC hydrogel films. The effect of silica NPs concentration on swelling properties of hydrogel was observed as well …”

Section: Nanocomposite Hydrogels Of Nanomaterials As Biomaterialsmentioning

confidence: 99%

Self-assembled Monolayers and Nanocomposite Hydrogels of Functional Nanomaterials for Tissue Engineering Applications

2014

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In biotechnology, SAMs and NC hydrogels of functional nanomaterials are of high interest as 2D and 3D cell culture systems, respectively, to mimic natural ECM and to control cell behaviors. Advanced biotechnological approaches often use nanoscale topography together with suitable surface functionalization, as a model of ECM, to control cell behaviors and tissue formation. SAMs of NMs are effective ECM models as 2D surfaces due to their larger nanostructured surface areas which provide higher molecular density by functionalization on a planar substrate than molecular SAMs. Additionally, NC hydrogels, produced by cross-linking of organic polymers with NMs, are excellent candidates as 3D cell culture systems owing to their optical, cell-compatibility and the extraordinary mechanical properties.

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Macromol. Biosci. 12/2010

Cited by 17 publications

References 0 publications

Robust and Adhesive Hydrogels from Cross‐Linked Poly(ethylene glycol) and Silicate for Biomedical Use

Robust and Adhesive Hydrogels from Cross‐Linked Poly(ethylene glycol) and Silicate for Biomedical Use

Highly Extensible Bio‐Nanocomposite Fibers

Self-assembled Monolayers and Nanocomposite Hydrogels of Functional Nanomaterials for Tissue Engineering Applications

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