Macrolide combination antibiotic therapy should be prudently considered in complicated CAP cases and in regions with low macrolide susceptibility

Shih, Hsin I.; Hsu, Hui‐Ping; Hsien, Chih; Ko, Wen Chien

doi:10.1007/s00134-010-1946-x

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2015

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“…In the United States and in Europe, combined use of macrolides and β ‐lactams has been adapted for the treatment of invasive pneumococcal pneumonia (Shih et al . ). Eradication therapy for Helicobacter pylori has shown that regimens containing amoxycillin may prevent bacteria resistance resulting from the use of clarithromycin alone.…”

Section: Introductionmentioning

confidence: 97%

New erythromycin derivatives enhance β -lactam antibiotics against methicillin-resistant Staphylococcus aureus

Dong

et al. 2015

Lett Appl Microbiol

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This study is the first report on the synergy of anti-MRSA between new erythromycin derivatives and β-lactam antibiotics in vitro. The results show that although the erythromycin derivatives have poor anti-MRSA effects alone, they possess high synergism with oxacillin against MRSA ATCC43300 and clinically isolated MRSA. These novel compounds can significantly reduce the dosage of β-lactam antibiotics against MRSA, while this synergistic effect is different from the combination of β-lactams and β-lactamase inhibitors. The research may provide a new choice for the treatment of infection caused by MRSA and be useful to the research and development of new combination of medicines.

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Section: Introductionmentioning

confidence: 97%

New erythromycin derivatives enhance β -lactam antibiotics against methicillin-resistant Staphylococcus aureus

Dong

et al. 2015

Lett Appl Microbiol

View full text Add to dashboard Cite

show abstract

Macrolide combination antibiotic therapy should be prudently considered in complicated CAP cases and in regions with low macrolide susceptibility

Cited by 1 publication

References 5 publications

New erythromycin derivatives enhance β -lactam antibiotics against methicillin-resistant Staphylococcus aureus

New erythromycin derivatives enhance β -lactam antibiotics against methicillin-resistant Staphylococcus aureus

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