Macrolide biosynthesis—II

8-Deoxylankolide from a Lankamycin Producing Streptomyces spp.

“…(Received for publication February 10, 1997) 6 Recently a Streptomyces spp. isolated from a soil sample from the north-side ofChuncheon, Korea showed production of lankamycin and lankacidin C. Careful examination of the extract of the culture broth of the organism allowed isolation of several more compounds.…”

Antibiotika aus Gleitenden Bakterien, XLI. Zur Konstitution der Myxovirescine B ‐ T und Biogenese des Myxovirescins A

“…Wie schon die Hauptkomponente selbst, das Myxovirescin A, existieren viele der Derivate als Epimerenpaar rnit C-25 als dem epimeren Zentrum. Wir haben nur dann epimerenreine Komponenten beobachtet und isoliert, wenn sie in der L S H 1 ' " ' / ' "~" ' 1 " ' ' "~~' 1 " ' ' 26, , D (18), Q (6) und in R (12), sowie in den Derivaten L (3), E (4) und S (5).…”

Efficient syntheses of 13C‐labelled erythromycin biosynthetic intermediates. 2: (2S,3S,4S,5R,6R,7R)‐3,6,7‐trihydroxy‐2,4,6‐trimethyl[1‐13C]nonan‐5‐olide and S‐2‐acetylaminoethyl (2R,3S,4S,5R,6S,7R)‐3,5,6,7‐tetrahydroxy‐2,4,6‐trimethyl[1‐13C]nonanethioate

“…We efficiently synthesized 13 C-labelled putative erythromycin biosynthetic intermediates, 10a and 2b, via aldol condensation of aldehyde derived from the optically active synthetic intermediate 13 (obtained in our previous work for erythromycin A synthesis) and benzyl ester 14 derived from sodium [1][2][3][4][5][6][7][8][9][10][11][12][13] C]propionate (4) for investigations on the biosynthesis of erythromycin.…”

“…Cane et al obtained much information about the chain elongation process in the erythromycin biosynthetic pathways from feeding experiments with 2 H-, 13 C-and/or 18 O-labelled compounds in S. erythraea. [1][2][3][4][5] In addition, groups led by Leadlay and Katz have employed a genetic approach to study the biosynthesis of 6-deoxyerythronolide B, the first biosynthetic macrolide intermediate of erythromycin A, in S. erythraea. [6][7][8][9] We are interested in the biosynthetic pathways to 6-deoxyerythronolide B, especially the chain elongation mechanism in erythromycin biosynthesis.…”