Macrolide antibiotics broadly and distinctively inhibit cytokine and chemokine production by COPD sputum cells in vitro

Marjanović, Nikola; Bosnar, Martina; Michielin, Francesca; Willé, David; Anić-Milić, Tatjana; Čulić, Ognjen; Popović‐Grle, Sanja; Bogdan, Mile; Parnham, Michael J.; Haber, Vesna Eraković

doi:10.1016/j.phrs.2011.02.001

Cited by 63 publications

(65 citation statements)

References 48 publications

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“…In COPD, the overall profile of inhibition of inflammatory mediator production by COPD sputum cells appears to be qualitatively and quantitatively broader than that of glucocorticoids, p38 MAPK inhibitors and PDE4 inhibitors [122].…”

Section: Macrolidesmentioning

confidence: 98%

Emerging anti-inflammatory strategies for COPD

et al. 2012

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Section: Macrolidesmentioning

confidence: 98%

Emerging anti-inflammatory strategies for COPD

et al. 2012

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“…In COPD, the innate immune response by T cytotoxic cells is perhaps more important than the acquired immune response for the development of persistent and progressive inflammation and remodeling of the lungs [155,156].…”

Section: Pathogeny Of Desert Dust On Respiratory Diseasesmentioning

confidence: 99%

A Systematic Review of Global Desert Dust and Associated Human Health Effects

et al. 2016

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Dust storms and sandy dust events originating in arid and semi-arid areas can transport particulate material, pollutants, and potential transport long distances from their sources. Exposure to desert dust particles is generally acknowledged to endanger human health. However, most studies have examined anthropogenic particulate sources, with few studies considering contributions from natural desert dust. A systematic literature review was undertaken using the ISI Web of Knowledge and PubMed databases with the objective of identifying all studies presenting results on the potential health impact from desert dust particles across the world. This review reveals an imbalance between the areas most exposed to dust and the areas most studied in terms of health effects. Among the human health effects of dust storms are mortality and morbidity, arising from respiratory system, circulatory system, and other diseases. We summarize the quantitative results of current scientific health research and possible pathological mechanisms, and describe some of the many challenges related to understanding health effects from exposures to desert dust particles. Overall, for respiratory and circulatory mortality, both positive and negative associations have been reported for PM 10 of desert dust, but only a positive relationship was reported between PM 2.5-10 and mortality, and a positive relationship was also reported between PM 2.5 and human mortality. Future pathological studies should continue to focus on those mechanisms causing the most harmful effect of desert dust on respiratory and cardiovascular diseases. More attention should also be paid to the association between desert dust and the morbidity of other diseases, such as those affecting the reproductive system and nervous system.

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“…It also inhibits the neutrophil release of a large number of cytokines and chemokines, including IL-1β, IL-6, IL-10, tumour necrosis factor (TNF)-α, chemokine ligand (CCL) 1, CCL3, CCL5, CCL20 and CCL22, and granulocyte colony-stimulating factor (G-CSF), increases phagocytosis, attenuates the secretion of IL-12 by macrophages (thus reducing Th-1 responses and subsequent chronic inflammatory disease) and modulates the differentiation and maturation of dendritic cells [45][46][47][48].…”

Section: Immunomodulatory Activitiesmentioning

confidence: 99%

Azithromycin use in patients with cystic fibrosis

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2015

Eur J Clin Microbiol Infect Dis

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Rational antimicrobial administration is still considered to be the most effective therapeutic approach in cystic fibrosis (CF), and long-term treatment with azithromycin (Az) is included in the current guidelines for CF patients aged ≥ 6 years. Az has microbiological, immunomodulatory and anti-inflammatory properties that can reduce some of the biological problems that are among the causes of the progressive lung damage associated with CF. Moreover, although it is not active against Pseudomonas aeruginosa (the most important bacterial pathogen responsible for infectious exacerbations), it can be efficiently used in the case of P. aeruginosa infections because sub-inhibitory concentrations can reduce their pathogenic role by interfering with some bacterial activities and increasing their susceptibility to antibiotics. Az also has anti-viral activity that limits the risk of the bacterial pulmonary exacerbations that frequently occur after apparently mild viral infections. The available data seem to indicate that it is effective during its first year of administration, but the impact of longer treatment is debated. Other still undefined aspects of the use of Az include the possible emergence of antibiotic resistance in the other bacterial pathogens that usually colonise CF patients, the real incidence of adverse events and the drug's potential interference with other routine therapies.

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Macrolide antibiotics broadly and distinctively inhibit cytokine and chemokine production by COPD sputum cells in vitro

Cited by 63 publications

References 48 publications

Emerging anti-inflammatory strategies for COPD

Emerging anti-inflammatory strategies for COPD

A Systematic Review of Global Desert Dust and Associated Human Health Effects

Azithromycin use in patients with cystic fibrosis

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