Macrolide antibiotics as antiinflammatory agents: Roxithromycin in an unexpected role

Agen, C; Danesi, Romano; Blandizzi, Corrado; Costa, Mario; Stacchini, B.; Favini, P.; Tacca, M. Del

doi:10.1007/bf02027218

Cited by 56 publications

(32 citation statements)

References 23 publications

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“…6 . Also, macrolides exhibited less anti-inflammatory activity than ibuprofen; this is similar to the findings of Agen C et al 19 . Change in paw volume in the combination groups (Ibuprofen 100 mg/kg + Roxithromycin 20 mg/kg and Ibuprofen 100 mg/kg + Erythromycin 20 mg/kg) was not significantly different from that of Ibuprofen (p> 0.05); hence it appears that there is no additional anti-inflammatory activity in the combination groups.…”

Section: Discussionsupporting

confidence: 90%

Analgesic and Anti-inflammatory Activity of Roxithromycin and Erythromycin, Alone and in Combination with Ibuprofen: An Animal Study

Khobragade¹

2011

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Background: Several in-vitro, animal and clinical studies have reported anti-inflammatory activity of macrolides. Antiinflammatory properties of macrolides form the basis for their experimental use in airway inflammatory and infective conditions like asthma Materials and Method: After animal ethics committee approval, the anti-inflammatory and analgesic potentials of erythromycin (40 mg/kg) and roxithromycin (20 mg/kg) were evaluated in carrageenan-induced rat paw edema model and rat tail flick model respectively, in comparison and combination with ibuprofen (100 mg/kg) in albino wistar rats. Results and Interpretation: Both the macrolides were found to have significant anti-inflammatory activity, roxithromycin being slightly more efficacious than erythromycin. Combination with ibuprofen failed to produce improved benefit. Both the macrolides neither showed significant analgesic property alone, nor enhanced analgesic effect of ibuprofen significantly. Conclusion:The macrolides have shown anti-inflammatory activity and a tendency towards analgesic potential; possible mechanisms are discussed. Further studies are required before any recommendations can be made.

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Section: Discussionsupporting

confidence: 90%

Analgesic and Anti-inflammatory Activity of Roxithromycin and Erythromycin, Alone and in Combination with Ibuprofen: An Animal Study

Khobragade¹

2011

iosrphr

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“…Al, 1993). 10 Anti-inflammatory activity shown in our study to roxithromycin and azithromycin is in accordance with the above studies.…”

Section: Analgesic Activitysupporting

confidence: 92%

“…Macrolides have been shown to affect several pathways of the inflammatory processes such as the migration of neutrophils, the oxidative stress in phagocytes and the production of proinflammatory cytokines. 9 The anti-inflammatory activity of roxithromycin have been shown to be due to reduce production of nitric oxide (NO) and super oxide dismutase activity (Agen c. et. Al, 1993).…”

Section: Analgesic Activitymentioning

confidence: 99%

Study of CNS Effects of Macrolide Antibiotics: An Experimental Study

Deshmukh¹,

Tamboli²

2013

jemds

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ABSTRACT:Macrolides are an old, well established class of antibacterial agents which play an important role in the management of infectious diseases. The present study was undertaken to study the CNS effects of some of the macrolides antibiotics namely erythromycin, clarithromycin, azithromycin and roxithromycin in rats. 30 healthy adult albino rats of either sex of Haffkine's strain weighing 100-200g were used for the study. Each group consists of six animals. Various tests were used for screening of drugs on CNS activity. Amongst the macrolides namely erythromycin claritromycin, azithromycin and roxithromycin, only roxithromycin showed CNS depressant activity in rats. Similarly only roxithromycin and azithromycin showed anti-inflammatory property.

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“…Patients with cystic fibrosis experienced clinical improvement and fewer exacerbations on maintenance azithromycin therapy (138)(139)(140). Macrolide antibiotics exert both antiinflammatory and nonbactericidal antimicrobial effects (141)(142)(143). In a retrospective analysis of more than 200 lung transplant recipients, Johnson and colleagues (144) demonstrated a strong association between the use of statins to control hypercholesterolemia, and freedom from the development of BOS.…”

Section: Chronic Allograft Dysfunction: Ob/bos Markers Mechanisms Pmentioning

confidence: 99%

Lung Transplantation: Opportunities for Research and Clinical Advancement

Wilkes¹

2006

Am J Respir Crit Care Med

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Lung transplantation is the only definitive therapy for many forms of end-stage lung diseases. However, the success of lung transplantation is limited by many factors: (1 ) Too few lungs available for transplantation due to limited donors or injury to the donor lung; (2 ) current methods of preservation of excised lungs do not allow extended periods of time between procurement and implantation; (3 ) acute graft failure is more common with lungs than other solid organs, thus contributing to poorer short-term survival after lung transplant compared with that for recipients of other organs; (4 ) lung transplant recipients are particularly vulnerable to pulmonary infections; and (5 ) chronic allograft dysfunction, manifest by bronchiolitis obliterans syndrome, is frequent and limits long-term survival. Scientific advances may provide significant improvements in the outcome of lung transplantation. The National Heart, Lung, and Blood Institute convened a working group of investigators on June 14-15, 2004, in Bethesda, Maryland, to identify opportunities for scientific advancement in lung transplantation, including basic and clinical research. This workshop provides a framework to identify critical issues related to clinical lung transplantation, and to delineate important areas for productive scientific investigation. Keywords: allograft dysfunction; infection; ischemia-reperfusion injury; lung transplantation; obliterative bronchiolitis; rejectionThe transplantation of organs offers the promise of life-saving and life-enhancing therapy for a variety of ailments. Lung transplantation (LTx) has become an acceptable therapy to palliate patients with a variety of end-stage lung diseases. However, lung transplantation has not turned out to be a panacea for chronic lung disease because of significant limitations in the entire transplant process (Figure 1). First, there are not nearly enough suitable donor lungs to meet the needs of all patients with end-stage lung disease. As a result, more patients die waiting for transplants than from mortality associated with a lung transplant. Second, early graft survival after LTx is worse than for other types of organs transplanted (1). Finally, late survival after successful LTx is hampered by the development of chronic allograft dysfunction and by the life-limiting complications associated with conventional immunosuppressive medications. Two factors impede progress to address these problems: (1 ) lung transplant centers lack the infrastructure to facilitate prospective, multicenter clinical studies of sufficient power to address clinical questions and (2 ) there are too few investigators studying the biology of lung transplantation.The NHLBI convened a workshop on June 14-15, 2004, to better understand these complex problems and to identify strategies to address these and prioritize them. The topics addressed by participants were wide-ranging. They included the following: lung use rates from conventional brain-dead organ donors; safe limits for donor lung function; consideration o...

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Macrolide antibiotics as antiinflammatory agents: Roxithromycin in an unexpected role

Cited by 56 publications

References 23 publications

Analgesic and Anti-inflammatory Activity of Roxithromycin and Erythromycin, Alone and in Combination with Ibuprofen: An Animal Study

Analgesic and Anti-inflammatory Activity of Roxithromycin and Erythromycin, Alone and in Combination with Ibuprofen: An Animal Study

Study of CNS Effects of Macrolide Antibiotics: An Experimental Study

Lung Transplantation: Opportunities for Research and Clinical Advancement

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