Macrocyclic Conformational Switch Coupled with Pyridinium-Induced PET for Fluorescence Detection of Adenosine Triphosphate
Boris S. Morozov,
Fabiano Gargiulo,
Swapnil Ghule
et al.
Abstract:The
binding of nucleotides is crucial for signal transduction
as
it induces conformational protein changes, leading to downstream cellular
responses. Synthetic receptors that bind nucleotides and transduce
the binding event into global conformational rearrangements are highly
challenging to design, especially those that operate in an aqueous
solution. Much work is focused on evaluating functionalized dyes to
detect nucleotides, whereas coupling of a nucleotide-induced conformational
switching to a sensing even… Show more
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