Macrocarpins A–D, new cytotoxic nor-triterpenes from Maytenus macrocarpa

Antimicrobial activity of some medicinal barks used in Peruvian Amazon

“…Antifungal, larvicidal and repellent activity of Cordia alliodora (Chen et al, 1983;Ioset et al, 2000) and cytotoxic (Chavez et al, 2000) and antileishmanial (Perez-Victoria et al, 1999) activity of roots of Maytenus macrocarpa were previously reported. Stem bark of the latter showed no in vitro antibacterial activity (Kloucek et al, 2005).…”

“…Alkaloids from Abuta grandifolia (Steele et al, 1999), steroidal glycosides from aerial parts of Naucleopsis glabra (Shrestha et al, 1992), phenylpropanoids, hydroquinones and terpenoids from Cordia alliodora (Chen et al, 1983;Harwood et al, 1991;Ioset et al, 2000), and several terpenes from roots (Perez-Victoria et al, 1999;Chavez et al, 2000) and aerial parts (Chavez et al, 1997(Chavez et al, , 1998(Chavez et al, , 1999 of Maytenus macrocarpa were previously isolated.…”

Dihydro-β-agarofuran Sesquiterpenoids fromPlenckia integerrima

“…They include potent antitumor maytansinoids, macrocyclic spermidines, amphetaminelike sympathomimetic (−)-S-cathinone, terpenoids, cytotoxic cardenolides, and flavonoids [1][2][3]. The Celastraceae family is also a rich source of several terpenoids such as friedelane type-triterpenes (quinonemethide, enequinone-methide, and phenolic types), lupanes, oleananes, several types of dimeric triterpenes, diterpenes such as kaurane and abietane, sesquiterpenes, and sesquiterpene-triterpene hetero-Diels-Alder adducts [4][5][6][7][8]. However, the most widespread and characteristic metabolites of this family are a large group of unusually highly oxygenated sesquiterpenoids, based on the 5,11-epoxy-5β,10αeudesman-4-(14)-ene skeleton known as dihydro-β-agarofurans.…”

Maytenus macrocarpa (Ruiz & Pav.) Briq.: Phytochemistry and Pharmacological Activity

“…Recently, the NCI-60 cell line screen revealed that pristimerin ( 26 ) was active against UO-31 (renal carcinoma), T-47D (breast cancer), and A549 (non-small-cell lung cancer) human tumor cell lines with individual half maximal inhibition of cell proliferation (GI 50 ) values ranging from 0.12 µM to 1.2 µM [78]; therefore, pristimerin ( 26 ) would deserve further in vivo evaluation. Macrocarpine A ( 32 ), macrocarpine B ( 33 ), macrocarpine C ( 34 ), and macrocarpine D ( 35 ) were shown to be active against P-388D1 (mouse lymphoma), A-549 (human lung carcinoma), HT-29 (human colon carcinoma), and MEL-28 (human melanoma) cells with IC 50 ranging between 0.4 and 5.2 µM [24], whereas 28-hydroxyfriedelane-1,3-dione ( 22 ) was inactive against the same panel of cancer cell lines [16], but a positive control was missing in both studies. Compounds macrocarpine A–D ( 32–35 ) were isolated from a hexane fraction, which shows the relatively lipophilic characteristic that could impede their solubility in water and, therefore, the likelihood that they could be used as drugs [24].…”