Macroalgae-Derived Multifunctional Bioactive Substances: The Potential Applications for Food and Pharmaceuticals

Guo, Jia; Qi, Mei; Chen, Hongyu; Zhou, Chengxu; Ruan, Roger; Yan, Xiaojun; Cheng, Pengfei

doi:10.3390/foods11213455

Cited by 21 publications

(22 citation statements)

References 100 publications

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“…The ROS-induced DNA plasmid strand cleavage assay was performed as described previously [ 18 ]. At least three independent experiments were performed for each tested compound.…”

Section: Methodsmentioning

confidence: 99%

“…Microalgae contain a variety of cellular components such as proteins, cellulose, polysaccharides, minerals, and phenolic compounds, which exhibit beneficial properties for human health such as antioxidant, anticancer, antibacterial, antimicrobial, antifungal, and antihypertensive [ 13 ]. The interspecific variation in macroalgal biochemical composition is expected, as macroalgae belong to different phylogenetic groups (i.e., Phaeophyceae, Rhodopyta, Chlorophyta), as well as functional form groups (i.e., filamentous, coarsely-branch, sheet, thick-leathery), which determine their physiological processes [ 13 , 16 , 17 , 18 ]. Additionally, as macroalgae grow worldwide, they are exposed to various abiotic and biotic environmental stresses that stimulate the production of bioactive components such as polyphenols, fatty acids, sterols, and carbohydrates [ 13 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…The interspecific variation in macroalgal biochemical composition is expected, as macroalgae belong to different phylogenetic groups (i.e., Phaeophyceae, Rhodopyta, Chlorophyta), as well as functional form groups (i.e., filamentous, coarsely-branch, sheet, thick-leathery), which determine their physiological processes [ 13 , 16 , 17 , 18 ]. Additionally, as macroalgae grow worldwide, they are exposed to various abiotic and biotic environmental stresses that stimulate the production of bioactive components such as polyphenols, fatty acids, sterols, and carbohydrates [ 13 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Activity and Inhibition of Liver Cancer Cells’ Growth of Extracts from 14 Marine Macroalgae Species of the Mediterranean Sea

Goutzourelas

Kevrekidis

Barda

et al. 2023

Foods

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Macroalgae exhibit beneficial bioactivities for human health. Thus, the aim of the present study was to examine the antioxidant and anticancer potential of 14 macroalgae species’ extracts, namely, Gigartina pistillata, Gigartina teedei, Gracilaria gracilis, Gracilaria sp., Gracilaria bursa pastoris, Colpomenia sinuosa, Cystoseira amentacea, Cystoseira barbata, Cystoseira compressa, Sargassum vulgare, Padina pavonica, Codium fragile, Ulva intestinalis, and Ulva rigida, from the Aegean Sea, Greece. The antioxidant activity was assessed using DPPH, ABTS•+, •OH, and O2•− radicals’ scavenging assays, reducing power (RP), and protection from ROO•-induced DNA plasmid damage assays. Moreover, macroalgae extracts’ total polyphenol contents (TPCs) were assessed. Extracts’ inhibition against liver HepG2 cancer cell growth was assessed using the XTT assay. The results showed that G. teedei extract’s IC50 was the lowest in DPPH (0.31 ± 0.006 mg/mL), ABTS•+ (0.02 ± 0.001 mg/mL), •OH (0.10 ± 0.007 mg/mL), O2•− (0.05 ± 0.003 mg/mL), and DNA plasmid breakage (0.038 ± 0.002 mg/mL) and exhibited the highest RP (RP0.5AU 0.24 ± 0.019 mg/mL) and TPC (12.53 ± 0.88 mg GAE/g dw). There was also a significant correlation between antioxidant activity and TPC. P. pavonica (IC50 0.93 ± 0.006 mg/mL) exhibited the highest inhibition against HepG2 cell growth. Conclusively, some of the tested extracts exhibited significant chemopreventive properties, and so they may be used for food products.

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“…The ROS-induced DNA plasmid strand cleavage assay was performed as described previously [ 18 ]. At least three independent experiments were performed for each tested compound.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antioxidant Activity and Inhibition of Liver Cancer Cells’ Growth of Extracts from 14 Marine Macroalgae Species of the Mediterranean Sea

Goutzourelas

Kevrekidis

Barda

et al. 2023

Foods

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“…109 Chlorella vulgaris has been extensively exploited for biomass production from food waste, sludge extracts, corn steep liquor, cheese whey, vinasse, tofu wastewater, and industrial dairy effluents. [110][111][112] Recently the ability of Arthrospira platensis to accumulate lipids during mixotrophic growth on dairy wastewater has been evaluated, 113 obtaining about 5 g/L of total biomass concentration with about 30% of lipid content. Arthrospira platensis has also been applied to treat piggery wastewater, confectionary effluent, composite media containing minerals, beet vinasse, and distillery wastewater.…”

Section: Safety Concerns and Legislationmentioning

confidence: 99%

Current challenges of microalgae applications: exploiting the potential of non‐conventional microalgae species

Occhipinti,

Russo,

Foti

et al. 2023

J Sci Food Agric

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The intensified attention to health, the growth of an elderly population, the changing lifestyles, and the medical discoveries have increased demand for natural and nutrient‐rich foods, shaping the popularity of microalgae products. Microalgae thanks to their metabolic versatility represent a promising solution for a ‘green’ economy, exploiting non‐arable land, non‐potable water, capturing carbon dioxide (CO2) and solar energy. The interest in microalgae is justified by their high content of bioactive molecules, such as amino acids, peptides, proteins, carbohydrates, polysaccharides, polyunsaturated fatty acids (as ω‐3 fatty acids), pigments (as β‐carotene, astaxanthin, fucoxanthin, phycocyanin, zeaxanthin and lutein), or mineral elements. Such molecules are of interest for human and animal nutrition, cosmetic and biofuel production, for which microalgae are potential renewable sources. Microalgae, also, represent effective biological systems for treating a variety of wastewaters and can be used as a CO2 mitigation approach, helping to combat greenhouse gases and global warming emergencies. Recently a growing interest has focused on extremophilic microalgae species, which are easier to cultivate axenically and represent good candidates for open pond cultivation. In some cases, the cultivation and/or harvesting systems are still immature, but novel techniques appear as promising solutions to overcome such barriers. This review provides an overview on the actual microalgae cultivation systems and the current state of their biotechnological applications to obtain high value compounds or ingredients. Moreover, potential and future research opportunities for environment, human and animal benefits are pointed out. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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“…This report mentioned the importance of these organisms for research, for example, in the areas of medicine, cosmetics, water treatment, food industry, and biofuels [ 1 ]. In this context, seaweeds stand out for their properties and benefits towards human health and the development of functional aliments [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Indoor and Outdoor Cultures of Gracilaria chilensis: Determination of Biomass Growth and Molecular Markers for Biomass Quality Evaluation

Caroca-Valencia

Rivas

Araya

et al. 2023

Plants

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Taking into consideration climate change scenarios, marine contamination, and a constantly expanding world population, seaweed aquaculture has become an important option for the large-scale production of high-quality biomass. Due to existing biological knowledge of Gracilaria chilensis, several cultivation strategies have been established for obtaining diverse biomolecules (lipids, fatty acids, pigments, among others) with nutraceutical properties. In this research, indoor and outdoor cultivation methodologies were applied to generate high biomass of G. chilensis with positive quality for productive purposes, where the quality was determined according to the concentrations of lipoperoxides and phenolic compounds and the total antioxidant capacity (TAC). The results showed that G. chilensis cultures, which were fertilized for three weeks with Basfoliar® Aktiv (BF) at concentrations of 0.05–1% v/v, obtained high biomass (1–1.3 kg m–2) and DGR (0.35–4.66% d–1), low lipoperoxides (0.5–2.8 µmol g–1 DT), and high phenolic compounds (0.4–0.92 µ eq. GA g–1 FT) and TAC (5–7.5 nmol eq. TROLOX g–1 FT) as compared with other culture media. Lower stress was determined under indoor cultures, due to the operative control of diverse physicochemical stressor parameters (T°, light intensity, photoperiod, among others). Therefore, the cultures developed allow scaling the biomass in productive terms and are suitable for obtaining compounds of interest.

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Macroalgae-Derived Multifunctional Bioactive Substances: The Potential Applications for Food and Pharmaceuticals

Cited by 21 publications

References 100 publications

Antioxidant Activity and Inhibition of Liver Cancer Cells’ Growth of Extracts from 14 Marine Macroalgae Species of the Mediterranean Sea

Antioxidant Activity and Inhibition of Liver Cancer Cells’ Growth of Extracts from 14 Marine Macroalgae Species of the Mediterranean Sea

Current challenges of microalgae applications: exploiting the potential of non‐conventional microalgae species

Indoor and Outdoor Cultures of Gracilaria chilensis: Determination of Biomass Growth and Molecular Markers for Biomass Quality Evaluation

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