Macro-CK and CK-BB Contributing to Sham CK-MB Elevation

Wada, Yuki; Tanigawa, Jun; Ishizaka, Nobukazu

doi:10.2169/internalmedicine.56.8329

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…In cases where CK-BB [ 14 ] or macro-CK [ 7 , 15 ] is present in the serum of tumor patients, even without myocardial injury, abnormal results indicating increased CK-MB activity may occur [ 14 , 16 ]. In situations where a significant amount of CK-BB and macro-CK is present, abnormal results may occur where CK-MB exceeds the total CK ratio (CK-MB > CK) [ 17 ]. Previous studies have highlighted CRC as the most common malignancy with abnormal CK-MB > CK results [ 13 , 18 ] (Fig.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of creatine kinase (CK)-MB to total-CK ratio in colorectal cancer patients after curative resection

Rao,

Xu,

Zhang

et al. 2024

BMC Cancer

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Objectives This study aimed to evaluate the prognostic significance of postoperative Creatine Kinase type M and B (CK-MB) to total Creatine Kinase (CK) ratio (CK-MB/CK) in colorectal cancer (CRC) patients after radical resection. Methods This was a single-center retrospective cohort analysis. Subjects were stage I-III CRC patients hospitalized in Sichuan Cancer Hospital from January 2017 to May 2021. Patients were divided into abnormal group and normal group according to whether the CK-MB/CK ratio was abnormal after surgery. Through a comparative analysis of clinical data, laboratory test results, and prognosis differences between the two groups, we aimed to uncover the potential relationship between abnormal CK-MB > CK results and CRC patients. To gauge the impact of CK-MB/CK on overall survival (OS) and disease-free survival (DFS), we employed the multivariable COX regression and LASSO regression analysis. Additionally, Spearman correlation analysis, logistic regression, and receiver-operating characteristic (ROC) curve analysis were conducted to assess the predictive value of the CK-MB/CK ratio for postoperative liver metastasis. Results Cox regression analysis revealed that the CK-MB/CK ratio was a stable risk factors for OS (HR = 3.82, p < 0.001) and DFS (HR = 2.31, p < 0.001). To distinguish hepatic metastases after surgery, the ROC area under the curve of CK-MB/CK was 0.697 (p < 0.001), and the optimal cut-off value determined by the Youden index was 0.347. Conclusions Postoperative abnormal CK-MB/CK ratio predicts worse prognosis in CRC patients after radical resection and serves as a useful biomarker for detecting postoperative liver metastasis.

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Section: Introductionmentioning

confidence: 99%

Prognostic value of creatine kinase (CK)-MB to total-CK ratio in colorectal cancer patients after curative resection

Rao,

Xu,

Zhang

et al. 2024

BMC Cancer

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“…When CK-BB [14] or macro-CK [7,15] is presented in the serum of tumor patients, even without myocardial injury, detected by the immunoinhibition method, abnormal results of increased CK-MB activity could occur [14,16]. When a large number of CK-BB and macro-CK exist, there may even be an abnormal situation with CK-MB to total CK ratio (CK-MB/CK) exceeding 1 [17]. The most common malignant tumor with CK-MB/CK greater than 1(CK-MB/CK > 1) was CRC [13,18].…”

Section: Introductionmentioning

confidence: 99%

Prognostic impact of Creatine Kinase (CK)-MB to total-CK ratio following curative resection of stage I-III colorectal cancer

Rao

Zhang

Luo

et al. 2023

Preprint

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Objectives: The purpose of this study was to evaluate the prognostic significance of Creatine Kinase (CK)-MB to total-CK ratio (CK-MB/CK) in patients with stage I-III colorectal cancer (CRC) after radical resection. Methods: This study was a single-center retrospective cohort analysis. Subjects were stage I-III CRC patients hospitalized in Sichuan Cancer Hospital from January 2017 to May 2021, who underwent curative resection. The overall survival (OS), disease-free survival rate (DFS), and recurrence were analyzed between two groups according to the serum CK-MB/CK levels after surgery, as follows: patients with postoperative CK-MB/CK greater than 1 (CK-MB/CK > 1) classified as the elevated group, and patients without postoperative CK-MB/CK greater than 1 (CK-MB/CK ≤ 1) classified as the normal group. Cox regression analyses, Kaplan-Meier method, and receiver-operating characteristic (ROC) curve were performed. Results: CK-MB/CK > 1 was the strongest independent prognostic factor for OS, DFS, and recurrence. Compared to the normal group (n = 1177), the elevated group (n = 95) had worse OS (HR, 5.64; 95% CI, 2.533–12.536; p < 0.0001), worse DFS (HR, 8.34; 95% CI, 5.205–13.366; p < 0.0001), and higher recurrence rate (HR, 9.44; 95% CI, 6.014–14.828; p < 0.0001). Serum CK-MB/CK levels in patients with hepatic metastasis after surgery were significantly higher than those in patients without hepatic metastasis (median 0.35 and 0.09, respectively; Mann-Whitney p = 0.000). For the diagnosis of hepatic metastases after surgery, the ROC area under the curve (AUC) of CK-MB/CK was 0.720 [95% confidence interval (CI) 0.695–0.745; p < 0.001], CA19-9 was 0.723 (95% CI 0.692–0.753; p < 0.001), and CA242 was 0.687 (95% CI 0.661–0.713; p < 0.001). When CK-MB/CK > 1.01, the specificity was 94.84% and the negative predictive value (NPV) was 96.7%. Combined CK-MB/CK and CA19-9, the AUC value increased from 0.720 to 0.799 (p = 0.0362), with a sensitivity of 77.46% and a specificity of 97.25%. Conclusions: In stage I-III CRC patients with radical resection, patients with postoperative CK-MB/CK > 1 had a worse prognosis, a shorter survival time, and a higher risk of recurrence. CK-MB/CK might be a new biomarker for the diagnosis of hepatic metastasis in CRC patients after surgery, with high specificity and NPV.

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“…When CK-BB [14] or macro-CK [7,15] is presented in the serum of tumor patients, even without myocardial injury, detected by the immunoinhibition method, abnormal results of increased CK-MB activity could occur [14,16]. When a large number of CK-BB and macro-CK exist, there may even be an abnormal situation with CK-MB to total CK ratio (CK-MB/CK) exceeding 1 [17]. According to previous studies, the most common malignant tumor with CK-MB/CK greater than 1 was CRC [13,18].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of Creatine Kinase (CK)-MB to total-CK ratio in colorectal cancer patients after curative resection

Rao,

Zu,

Zhang

et al. 2023

Preprint

View full text Add to dashboard Cite

Objectives: This study aimed to evaluate the prognostic significance of postoperative Creatine Kinase (CK)-MB to total-CK ratio (CK-MB/CK) in colorectal cancer (CRC) patients after radical resection. Methods: This was a single-center retrospective cohort analysis. Subjects were stage I-III CRC patients hospitalized in Sichuan Cancer Hospital from January 2017 to May 2021. The overall survival (OS) and disease-free survival rate (DFS) were analyzed between two groups according to the serum CK-MB/CK levels after surgery. Cox regression analyses, Kaplan-Meier method, and receiver-operating characteristic (ROC) curve were performed. Results: CK-MB/CK was the strongest independent prognostic factor for OS and DFS. Compared to the normal group (n = 1177), the elevated group (n = 95) had worse OS (HR, 5.64; p < 0.0001) and DFS (HR, 8.34; p < 0.0001). For the diagnosis of hepatic metastases after surgery, the ROC area under the curve (AUC) of CK-MB/CK was 0.720 (p < 0.001). When CK-MB/CK > 1.01, the specificity was 94.84% and the negative predictive value (NPV) was 96.7%. Combined CK-MB/CK and CA19-9, the AUC value increased from 0.720 to 0.799 (p = 0.036), with a sensitivity of 77.46% and a specificity of 97.25%. Conclusions: CRC patients with elevated CK-MB/CK had a worse prognosis after radical resection. CK-MB/CK might be a new biomarker for the diagnosis of hepatic metastasis in CRC patients after surgery, with high specificity and NPV.

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Macro-CK and CK-BB Contributing to Sham CK-MB Elevation

Cited by 3 publications

References 2 publications

Prognostic value of creatine kinase (CK)-MB to total-CK ratio in colorectal cancer patients after curative resection

Prognostic value of creatine kinase (CK)-MB to total-CK ratio in colorectal cancer patients after curative resection

Prognostic impact of Creatine Kinase (CK)-MB to total-CK ratio following curative resection of stage I-III colorectal cancer

Prognostic value of Creatine Kinase (CK)-MB to total-CK ratio in colorectal cancer patients after curative resection

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