Macro- and microstructural tracking of ageing-related changes of papaverine hydrochloride-loaded electrospun nanofibrous buccal sheets

Kazsoki, Adrienn; Szabó, Péter; Süvegh, Károly; Vörös, Tamás; Zelkó, Romána

doi:10.1016/j.jpba.2017.05.035

Cited by 12 publications

(8 citation statements)

References 23 publications

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“…When compared to the 1% trolamine content, on the images of samples with 3% trolamine, the deterioration of nanofibers can be observed, which could be the consequence of the plasticization effect of higher trolamine content. The latter is in good agreement with the results of the authors’ previous works [29,30], where the film formation occurred as a result of the glassy-to-rubbery transition of the polymeric carriers. The moisture absorbed from the environment acts also as a plasticizer leading to a significant decrease of the T g of the fiber-forming polymers.…”

Section: Resultssupporting

confidence: 93%

“…Based on the extent of the peaks, it can be concluded, that the increased hygroscopicity of the fibers, on the one hand, can have a significant impact on the dissolution improvement of the active, but on the other hand it could initiate a glassy-to-rubbery transition of the PVP, thus destroying the fibrous structure. Similar pseudopolymorphism of the fiber-base polymer composite can be seen in the authors’ previous stability studies of papaverine hydrochloride-loaded electrospun nanofibrous buccal sheets [30]. The glass transition temperature of PVP K90 denoted by an endothermic change in the baseline thermal profiles (see blue insert) of reversible heat flow was 179 °C [33], which can be more sensitively detected at 5 °C/min heating rate.…”

Section: Resultssupporting

confidence: 72%

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Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs

et al. 2019

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Aceclofenac-loaded poly(vinyl-pyrrolidone)-based nanofiber formulations were prepared by electrospinning to obtain drug-loaded orally disintegrating webs to enhance the solubility and dissolution rate of the poorly soluble anti-inflammatory active that belongs to the BCS Class-II. Triethanolamine-containing ternary composite of aceclofenac-poly(vinyl-pyrrolidone) nanofibers were formulated to exert the synergistic effect on the drug-dissolution improvement. The composition and the electrospinning parameters were changed to select the fibrous sample of optimum fiber characteristics. To determine the morphology of the nanofibers, scanning electron microscopy was used. Fourier transform infrared spectroscopy (FT-IR), and differential scanning calorimetry (DSC) were applied for the solid-state characterization of the samples, while the drug release profile was followed by the in vitro dissolution test. The nanofibrous formulations had diameters in the range of few hundred nanometers. FT-IR spectra and DSC thermograms indicated the amorphization of aceclofenac, which resulted in a rapid release of the active substance. The characteristics of the selected ternary fiber composition (10 mg/g aceclofenac, 1% w/w triethanolamine, 15% w/w PVPK90) were found to be suitable for obtaining orally dissolving webs of fast dissolution and potential oral absorption.

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Section: Resultssupporting

confidence: 93%

Section: Resultssupporting

confidence: 72%

Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs

et al. 2019

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“…After two weeks, a new structure was formed, possibly involving hydrogen bonds between polymer chains. Longer exposure (two to four weeks) led to different structural organizations due to the destruction of hydrogen bonds [ 74 ].…”

Section: Resultsmentioning

confidence: 99%

Positron Annihilation Lifetime Spectroscopy as a Special Technique for the Solid-State Characterization of Pharmaceutical Excipients, Drug Delivery Systems, and Medical Devices—A Systematic Review

et al. 2023

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The aims of this systematic review are to explore the possibilities of using the positron annihilation lifetime spectroscopy (PALS) method in the pharmaceutical industry and to examine the application of PALS as a supportive, predictive method during the research process. In addition, the review aims to provide a comprehensive picture of additional medical and pharmaceutical uses, as the application of the PALS test method is limited and not widely known in this sector. We collected the scientific literature of the last 20 years (2002–2022) from several databases (PubMed, Embase, SciFinder-n, and Google Scholar) and evaluated the data gathered in relation to the combination of three directives, namely, the utilization of the PALS method, the testing of solid systems, and their application in the medical and pharmaceutical fields. The application of the PALS method is discussed based on three large groups: substances, drug delivery systems, and medical devices, starting with simpler systems and moving to more complex ones. The results are discussed based on the functionality of the PALS method, via microstructural analysis, the tracking of ageing and microstructural changes during stability testing, the examination of the effects of excipients and external factors, and defect characterization, with a strong emphasis on the benefits of this technique. The review highlights the wide range of possible applications of the PALS method as a non-invasive analytical tool for examining microstructures and monitoring changes; it can be effectively applied in many fields, alone or with complementary testing methods.

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“…The spectra were evaluated by the RESOLUTION computer code. Three lifetime components were found in all samples, and the longest component was identified as positronium triplet state (o-Ps) lifetime [30].…”

Section: Methodsmentioning

confidence: 99%

Fused Deposition Modeling 3D Printing: Test Platforms for Evaluating Post-Fabrication Chemical Modifications and In-Vitro Biological Properties

et al. 2019

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3D printing is attracting considerable interest for its capacity to produce prototypes and small production runs rapidly. Fused deposit modeling (FDM) was used to produce polyvalent test plates for investigation of the physical, chemical, and in-vitro biological properties of printed materials. The polyvalent test plates (PVTPs) are poly-lactic acid cylinders, 14 mm in diameter and 3 mm in height. The polymer ester backbone was surface modified by a series of ramified and linear oligoamines to increase its hydrophilicity and introduce a positive charge. The chemical modification was verified by FT-IR spectroscopy, showing the introduction of amide and amine functions, and contact angle measurements confirmed increased hydrophilicity. Morphology studies (SEM, optical microscopy) indicated that the modification of PVTP possessed a planar morphology with small pits. Positron annihilation lifetime spectroscopy demonstrated that the polymeric free volume decreased on modification. An MTT-based prolonged cytotoxicity test using Caco-2 cells showed that the PVTPs are non-toxic at the cellular level. The presence of surface oligoamines on the PVTPs reduced biofilm formation by Candida albicans SC5314 significantly. The results demonstrate that 3D printed objects may be modified at their surface by a simple amidation reaction, resulting in a reduced propensity for biofilm colonization and cellular toxicity.

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Macro- and microstructural tracking of ageing-related changes of papaverine hydrochloride-loaded electrospun nanofibrous buccal sheets

Cited by 12 publications

References 23 publications

Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs

Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs

Positron Annihilation Lifetime Spectroscopy as a Special Technique for the Solid-State Characterization of Pharmaceutical Excipients, Drug Delivery Systems, and Medical Devices—A Systematic Review

Fused Deposition Modeling 3D Printing: Test Platforms for Evaluating Post-Fabrication Chemical Modifications and In-Vitro Biological Properties

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