Macoma birmanica agglutinin recognizes glycoside clusters of β-GlcNAc/Glc and α-Man

Gal/GalNAc specific multiple lectins in marine bivalve Anadara granosa

“…Although monosaccharide affinity of lectins is very specific, it is weaker than that with polyvalent glycotopes. Polyvalent glycotopes with appropriate sugar sequences and required geometry could lead to a great increase of binding affinity with lectins [19,31,34]. Natural polyvalent glycoproteins with well-defined glycotopes were used in the present binding study to mimic the natural phenomenon.…”

“…However, detailed carbohydrate recognition patterns of very few of them like codakine [16], Macoma birmanica agglutinin (MBA) [19] and Aplysia gonad lectin [20] were studied. MBA was found to be b-GlcNAc/aMan specific and polyvalent glycoside clusters of GlcNAcb1e2Mana1e was the most potent binding motif [19]. Codakine was a Fuc and Man-specific lectin and had a very fine specificity for N-linked biantennary complex type glycan [16].…”

“…Lectins from several marine bivalves were purified and characterized for their role as a crucial player in host defense against foreign substances [4e18]. However, detailed carbohydrate recognition patterns of very few of them like codakine [16], Macoma birmanica agglutinin (MBA) [19] and Aplysia gonad lectin [20] were studied. MBA was found to be b-GlcNAc/aMan specific and polyvalent glycoside clusters of GlcNAcb1e2Mana1e was the most potent binding motif [19].…”

Defensins – natural peptide antibiotics of higher eucariotes

“…Ряд исследований показывает, что, например, L-фиколин и подобные ему LTAB-белки, способны специфично взаимодействовать с липотейхоевой кислотой (LTA), являющейся облигатным компонентом клеточной оболочки всех грамположительных бактерий [42,43]. Целым рядом исследователей также были охарактеризованы белки, обладающие высокой степенью избирательности связывания с липополисахаридами грамотрицательных бактерий [44][45][46].…”